Biological properties of volatile oil from Brazilian brown propolis

Lima, Vitor Hugo Melo de; Almeida, Karoliny de Cassia Rodrigues; Alves, Cássia Cristina Fernandes; Rodrigues, Matheus Leandro; Crotti, Antônio Eduardo Miller; Souza, João Matias de; Ribeiro, Arthur Barcelos; Squarisi, Iara Silva; Tavares, Denise Crispim; Martins, Carlos Henrique Gomes; Miranda, Mayker Lázaro Dantas

doi:10.1016/j.bjp.2019.07.004

Cited by 22 publications

(15 citation statements)

References 15 publications

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“…In general, propolis is known for its antioxidant effects; several studies show the capacity of propolis to decrease oxidative stress in different models inducing gastric ulcers [ 58 , 59 , 60 , 61 , 62 , 63 , 65 , 66 , 182 , 183 ]. The antioxidant effects also are involved in the gastroprotection of propolis in NSAIDs-induced gastric ulcers [ 58 , 59 , 60 ] ( Figure 3 ).…”

Section: Discussionmentioning

confidence: 99%

Propolis and Its Gastroprotective Effects on NSAID-Induced Gastric Ulcer Disease: A Systematic Review

et al. 2021

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Gastric ulcer disease induced by the consumption of NSAIDs is a major public health problem. The therapy used for its treatment causes adverse effects in the patient. Propolis is a natural product that has been used for the treatments of different diseases around the world. Nevertheless, there is little information about the activity of propolis in gastric ulcers caused by treatment with NSAIDs. Therefore, this review evaluates and compares the gastroprotective potential of propolis and its function against NSAID-induced gastric ulcers, for which a systematic search was carried out in the PubMed and ScienceDirect databases. The main criteria were articles that report the gastroprotective activity of propolis against the damage produced by NSAIDs in the gastric mucosa. Gastroprotection was related to the antioxidant, antisecretory, and cytoprotective effects, as well as the phenolic compounds present in the chemical composition of propolis. However, most of the studies used different doses of NSAIDs and propolis and evaluated different parameters. Propolis has proven to be a good alternative for the treatment of gastric ulcer disease. However, future studies should be carried out to identify the compounds responsible for these effects and to determine their potential use in people.

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Section: Discussionmentioning

confidence: 99%

Propolis and Its Gastroprotective Effects on NSAID-Induced Gastric Ulcer Disease: A Systematic Review

et al. 2021

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“…The compounds nerolidol and spathulenol showed strong antimicrobial activity [10,39] . Nerolidol, spathulenol, and acetophenone were reported as major compounds in a brown propolis sample from the southeast region of Brazil, which also exhibited strong antibacterial activity [40] . The presence of nerolidol and spathulenol in the volatile fraction of propolis generally indicates B. dracunculifolia as a botanical source, as these compounds are chemical markers of this plant and play an essential role in attracting bees [38] …”

Section: Resultsmentioning

confidence: 99%

Phytochemical, Antiplasmodial, Cytotoxic and Antimicrobial Evaluation of a Southeast Brazilian Brown Propolis Produced by Apis mellifera Bees

Ribeiro

Arruda

Mejía

et al. 2021

Chemistry & Biodiversity

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Seven phenolic compounds (ferulic acid, caffeic acid, 4‐methoxycinnamic acid, 3,4‐dimethoxycinnamic acid, 3‐hydroxy‐4‐methoxybenzaldehyde, 3‐methoxy‐4‐hydroxypropiophenone and 1‐O,2‐O‐digalloyl‐6‐O‐trans‐p‐coumaroyl‐β‐D‐glucopyranoside), a flavanonol (7‐O‐methylaromadendrin), two lignans (pinoresinol and matairesinol) and six diterpenic acids/alcohol (19‐acetoxy‐13‐hydroxyabda‐8(17),14‐diene, totarol, 7‐oxodehydroabietic acid, dehydroabietic acid, communic acid and isopimaric acid) were isolated from the hydroalcoholic extract of a Brazilian Brown Propolis and characterized by NMR spectral data analysis. The volatile fraction of brown propolis was characterized by CG‐MS, composed mainly of monoterpenes and sesquiterpenes, being the major α‐pinene (18.4 %) and β‐pinene (10.3 %). This propolis chemical profile indicates that Pinus spp., Eucalyptus spp. and Araucaria angustifolia might be its primary plants source. The brown propolis displayed significant activity against Plasmodium falciparum D6 and W2 strains with IC50 of 5.3 and 9.7 μg/mL, respectively. The volatile fraction was also active with IC50 of 22.5 and 41.8 μg/mL, respectively. Among the compounds, 1‐O,2‐O‐digalloyl‐6‐O‐trans‐p‐coumaroyl‐β‐D‐glucopyranoside showed IC50 of 3.1 and 1.0 μg/mL against D6 and W2 strains, respectively, while communic acid showed an IC50 of 4.0 μg/mL against W2 strain. Cytotoxicity was determined on four tumor cell lines (SK‐MEL, KB, BT‐549, and SK‐OV‐3) and two normal renal cell lines (LLC‐PK1 and VERO). Matairesinol, 7‐O‐methylaromadendrin, and isopimaric acid showed an IC50 range of 1.8–0.78 μg/mL, 7.3–100 μg/mL, and 17–18 μg/mL, respectively, against the tumor cell lines but they were not cytotoxic against normal cell lines. The crude extract of brown propolis displayed antimicrobial activity against C. neoformans, methicillin‐resistant Staphylococcus aureus, and P. aeruginosa at 29.9 μg/mL, 178.9 μg/mL, and 160.7 μg/mL, respectively. The volatile fraction inhibited the growth of C. neoformans at 53.0 μg/mL. The compounds 3‐hydroxy‐4‐methoxybenzaldehyde, 3‐methoxy‐4‐hydroxypropiophenone and 7‐oxodehydroabietic acid were active against C. neoformans, and caffeic and communic acids were active against methicillin‐resistant Staphylococcus aureus.

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“…Volatile compounds constitute a small fraction of propolis and are important for characterizing its botanical origin [ 47 ]. In addition, volatile compounds can be used as food preservatives in propolis-based packaging [ 48 ] by exploiting their antioxidant [ 15 , 25 ], antifungal [ 49 , 50 ], antibacterial [ 51 ], and other biological activities [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

“…Propolis is a phytochemical and complex mixture composed of 50% resin (containing flavonoids and 66 phenolic acids), 30% wax, 10% essential oil, 5% pollen, and 5% other organic compounds [ 5 , 19 ]. Studies have reported that the volatile compound profile of propolis comprises a variety of chemicals and volatile compounds such as 1-methyl-naphthalene, naphthalene, 3-methyl-1-butanol [ 20 ], limonene, β -caryophyllene, nerolidol [ 21 ], ( E )-isoeugenol, linalool, butanoic acid [ 22 ], and acetophenone [ 23 ]. The chemical composition of propolis is related to the biosynthetic capacity of plants and their secondary metabolites used by bees [ 9 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition of Volatile Compounds in Apis mellifera Propolis from the Northeast Region of Pará State, Brazil

et al. 2021

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Propolis is a balsamic product obtained from vegetable resins by exotic Africanized bees Apis mellifera L., transported and processed by them, originating from the activity that explores and maintains these individuals. Because of its vegetable and natural origins, propolis is a complex mixture of different compound classes; among them are the volatile compounds present in the aroma. In this sense, in the present study we evaluated the volatile fraction of propolis present in the aroma obtained by distillation and simultaneous extraction, and its chemical composition was determined using coupled gas chromatography, mass spectrometry, and flame ionization detection. The majority of compounds were sesquiterpene and hydrocarbons, comprising 8.2–22.19% α-copaene and 6.2–21.7% β-caryophyllene, with additional compounds identified in greater concentrations. Multivariate analysis showed that samples collected from one region may have different chemical compositions, which may be related to the location of the resin’s production. This may be related to other bee products.

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Biological properties of volatile oil from Brazilian brown propolis

Cited by 22 publications

References 15 publications

Propolis and Its Gastroprotective Effects on NSAID-Induced Gastric Ulcer Disease: A Systematic Review

Propolis and Its Gastroprotective Effects on NSAID-Induced Gastric Ulcer Disease: A Systematic Review

Phytochemical, Antiplasmodial, Cytotoxic and Antimicrobial Evaluation of a Southeast Brazilian Brown Propolis Produced by Apis mellifera Bees

Chemical Composition of Volatile Compounds in Apis mellifera Propolis from the Northeast Region of Pará State, Brazil

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