Parietin as an efficient and promising anti-angiogenic and apoptotic small-molecule from Xanthoria parietina

Varol, Mehmet

doi:10.1016/j.bjp.2019.04.012

Cited by 10 publications

(8 citation statements)

References 25 publications

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“…has shown a higher phenolic content in X. parietina and important antioxidant activity; this species also showed an antibacterial effect [9] . X. parietina is also known for its major metabolite, parietin an orange anthraquinone pigment characterized for its antibacterial, anticancer, antiproliferative, and antifungal activities [40–41] . Also, it may reduce the effect of UV radiations [42] …”

Section: Discussionmentioning

confidence: 99%

Anti‐Inflammatory Potential of Compounds Isolated from Tunisian Lichens Species

Greca

Mendili

Khadhri

et al. 2022

Chemistry & Biodiversity

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The lichen's special symbiotic structure enables it to produce bioactive substances. They have historically been recognized for their aesthetic and medicinal benefits. Furthermore, in recent years, they have performed in various fields, including perfumery, dyeing, and pharmacology due to their rich secondary metabolites. From our study, four compounds were isolated from organic extracts of Parmotrema hypoleucinum, Roccella phycopsis, and Xanthoria parietina and identified by spectroscopic investigation as atranorin, (+)-iso-usnic acid, methyl orsellinate, and parietin, respectively. The anti-inflammatory effects of lichens extracts, and pure compounds were evaluated on RAW 264.7 macrophages cells at different concentrations. At 25 μg/mL all treated samples did not show any effect on cell viability. Atranorin and (+)-iso-usnic acid showed an inhibitory effect on nitric oxide (NO) levels in lipopolysaccharide (LPS)-stimulated macrophages. Nitric oxide (NO) production was measured using Griess reagent, atranorin and (+)-iso-usnic acid showed a high anti-inflammatory potential (75.99 % and 57.27 % at 25 μg/mL). On the other hand, methyl orsellinate and the organic extracts of three lichens showed good anti-inflammatory activity ranging from 29.16 % at 25 μg/mL to 86.91 % at 100 μg/mL.

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Section: Discussionmentioning

confidence: 99%

Anti‐Inflammatory Potential of Compounds Isolated from Tunisian Lichens Species

Greca

Mendili

Khadhri

et al. 2022

Chemistry & Biodiversity

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“…Parietin (it is also known as Physcion) is an anthraquinone pigment found as a secondary metabolite in lichens, for example, Xanthoria parietina, Teloschistes flavicans, and Rheum ribes L., (Gundogdu et al, 2018;Tuncer & Günsan, 2017;Varol, 2019). The chemical structure of parietin is shown in Figure 10.…”

Section: Parietinmentioning

confidence: 99%

“…Parietin has different effects such as antibacterial, anticancer, antiproliferative, and antifungal effects on different cell types (Gundogdu et al, 2018). Varol (2019) investigated the antiangiogenic effect of parietin on HUVECs for the first time. In this study, the effects of parietin on cell proliferation and tube formation, which are two important steps of angiogenesis, were studied.…”

Section: Parietinmentioning

confidence: 99%

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Antiangiogenic properties of lichen secondary metabolites

Ulus

2021

Phytotherapy Research

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Lichens are symbiotic organisms which are composed fungi and algae and/or cyanobacteria. They produce a variety of characteristic secondary metabolites. Such substances have various biological properties including antimicrobial, antiviral, and antitumor activities. Angiogenesis, the growth of new vessels from pre-existing vessels, contributes to numerous diseases including cancer, arthritis, atherosclerosis, infectious, and immune disorders. Antiangiogenic therapy is a promising approach for the treatment of such diseases by inhibiting the new vessel formation. Technological advances have led to the development of various antiangiogenic agents and have made possible antiangiogenic therapy in many diseases associated with angiogenesis. Some lichens and their metabolites are used in the drug industry, but many have not yet been tested for their antiangiogenic effects. The cytotoxic and angiogenic capacities of lichen-derived small molecules have been demonstrated in vivo and in vitro experiments. Therefore, some of them may be used as antiangiogenic agents in the future. The secondary compounds of lichen whose antiangiogenic effect has been studied in the literature are usnic acid, barbatolic acid, vulpinic acid, olivetoric acid, emodin, secalonic acid D, and parietin. In this article, we review the antiangiogenic effects and cellular targets of these lichen-derived metabolites.

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“…The naturally occurring PSs, curcumin (CUR) and parietin (PTN), offer promising therapeutic options but exhibit poor physicochemical properties, such as limited solubility or permeability, and are categorized in BCS (biopharmaceutics classification system) class IV. − Among other PSs, e.g., porphyrins, phthalocyanines, indocyanine dyes, and BODIPYs, CUR, an orange-yellow polyphenolic compound found in the rhizome Curcuma longa L., was a relatively new substance in PDT in 2016, primarily used in dentistry . Over the years, its use in PDT research increased, displaying good phototoxicity results against cancer cells .…”

Section: Introductionmentioning

confidence: 99%

Modern Photodynamic Glioblastoma Therapy Using Curcumin- or Parietin-Loaded Lipid Nanoparticles in a CAM Model Study

Schulze,

Schöne,

Ayoub

et al. 2023

ACS Appl. Bio Mater.

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Parietin as an efficient and promising anti-angiogenic and apoptotic small-molecule from Xanthoria parietina

Cited by 10 publications

References 25 publications

Anti‐Inflammatory Potential of Compounds Isolated from Tunisian Lichens Species

Anti‐Inflammatory Potential of Compounds Isolated from Tunisian Lichens Species

Antiangiogenic properties of lichen secondary metabolites

Modern Photodynamic Glioblastoma Therapy Using Curcumin- or Parietin-Loaded Lipid Nanoparticles in a CAM Model Study

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