Cardiac glycosides from Cascabela thevetioides by HPLC-MS analysis

Balderas-López, José Luis; Barbonetti, Simone; Pineda-Rosas, Erika Lizbeth; Tavares-Carvalho, José Carlos; Castro, Andrés Navarrete

doi:10.1016/j.bjp.2019.04.008

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…[ 19 , 20 , 21 , 22 ] or oleanders ( Nerium sp.) [ 23 , 24 , 25 , 26 ], but also animals, e.g., in the skin of particular amphibians such as toads ( Bufa bufa and others) [ 27 , 28 ]. Besides, there are equivalents of CGs also in humans, referred to as digitalis-like factors [ 29 , 30 ].…”

Section: Cellular Targets Of Cardiac Glycosidesmentioning

confidence: 99%

Cardiac Glycosides as Immune System Modulators

2021

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Cardiac glycosides (CGs) are natural steroid compounds occurring both in plants and animals. They are known for long as cardiotonic agents commonly used for various cardiac diseases due to inhibition of Na+/K+-ATPase (NKA) pumping activity and modulating heart muscle contractility. However, recent studies show that the portfolio of diseases potentially treatable with CGs is much broader. Currently, CGs are mostly studied as anticancer agents. Their antiproliferative properties are based on the induction of multiple signaling pathways in an NKA signalosome complex. In addition, they are strongly connected to immunogenic cell death, a complex mechanism of induction of anticancer immune response. Moreover, CGs exert various immunomodulatory effects, the foremost of which are connected with suppressing the activity of T-helper cells or modulating transcription of many immune response genes by inhibiting nuclear factor kappa B. The resulting modulations of cytokine and chemokine levels and changes in immune cell ratios could be potentially useful in treating sundry autoimmune and inflammatory diseases. This review aims to summarize current knowledge in the field of immunomodulatory properties of CGs and emphasize the large area of potential clinical use of these compounds.

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Section: Cellular Targets Of Cardiac Glycosidesmentioning

confidence: 99%

Cardiac Glycosides as Immune System Modulators

2021

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“…The milkweed species belong to Asclepias, and the family Asclepiadaceae, which is reported to produce the toxic cardenolide calotropin. Besides, a poisonous CG like thevetin was found in the South American ornamental shrub Cascabela thevetioides (Kunth) [ 29 ], and convallatoxin was reported in the plant Convallaria majalis [ 30 ]. The cardiotonic steroid bufalin was found in the dried venom obtained from the parotoid gland of the Chinese bufo toad, and steroids including marinobufagenin and telocinobufagin were isolated from the skin sample secretions of the Brazilian toad, Bufo rubescens , and the giant neotropical marine toad Rhinella marina [ 31 , 32 ].…”

Section: Cardiac Glycosidesmentioning

confidence: 99%

Emergence of Cardiac Glycosides as Potential Drugs: Current and Future Scope for Cancer Therapeutics

et al. 2021

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Cardiac glycosides are natural sterols and constitute a group of secondary metabolites isolated from plants and animals. These cardiotonic agents are well recognized and accepted in the treatment of various cardiac diseases as they can increase the rate of cardiac contractions by acting on the cellular sodium potassium ATPase pump. However, a growing number of recent efforts were focused on exploring the antitumor and antiviral potential of these compounds. Several reports suggest their antitumor properties and hence, today cardiac glycosides (CG) represent the most diversified naturally derived compounds strongly recommended for the treatment of various cancers. Mutated or dysregulated transcription factors have also gained prominence as potential therapeutic targets that can be selectively targeted. Thus, we have explored the recent advances in CGs mediated cancer scope and have considered various signaling pathways, molecular aberration, transcription factors (TFs), and oncogenic genes to highlight potential therapeutic targets in cancer management.

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Cardiac glycosides from Cascabela thevetioides by HPLC-MS analysis

Cited by 2 publications

References 7 publications

Cardiac Glycosides as Immune System Modulators

Cardiac Glycosides as Immune System Modulators

Emergence of Cardiac Glycosides as Potential Drugs: Current and Future Scope for Cancer Therapeutics

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