Kalanchoe laciniata and Bryophyllum pinnatum: an updated review about ethnopharmacology, phytochemistry, pharmacology and toxicology

Fernandes, Júlia Morais; Cunha, Lorena Medeiros da; Azevedo, Eduardo Pereira de; Lourenço, Estela Mariana Guimarães; Fernandes-Pedrosa, Matheus de Freitas; Zucolotto, Silvana Maria

doi:10.1016/j.bjp.2019.01.012

Cited by 55 publications

(60 citation statements)

References 181 publications

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“…Applications of medicinal plants in both the prevention and treatment of chronic inflammatory diseases has been widely described in the literature (Kim et al, 2018). Specifically regarding Bryophyllum pinnatum, its use has been recognized in in vivo studies to treat some inflammatory diseases and for healing wounds (dos Santos Nascimento et al, 2018;Fernandes et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…Although B. pinnatum is widely used by traditional medicine practitioners, its chemical constituents have not been fully elucidated. Few investigations have involved isolating and elucidating its bioactive compounds until now, but most of the studies have indicated the presence of glycosylated flavonoids, with acetylated rhamnose sugar linked to different positions of aglycone (Fernandes et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…Among the constituents analyzed in B. pinnatum leaf, quercetin 3-O-a-L-arabinopyranosyl-(1!2)-a-L-rhamnopyranoside (Bp1) was the first compound isolated for this specie (Muzitano et al, 2006), and it is the major compound reported in literature (Sobreira et al, 2017;dos Santos Nascimento et al, 2018). Fernandes et al (2019) and Ferreira et al (2014) reported other compounds already described for B. pinnatum: kaempferol 3-O-a-L-arabinopyranosyl-(1!2)-a-L-rhamnopyranoside (Bp2) and quercetin-3-Orhamnopyranoside (Bp3). These three compounds are considered as potential candidates for specific markers of this species and can be used in authenticating its raw material (dos Santos Nascimento et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Anti-Inflammatory and Chemopreventive Effects of Bryophyllum pinnatum (Lamarck) Leaf Extract in Experimental Colitis Models in Rodents

et al. 2020

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pro-inflammatory and oxidative mediators, chemokines, and cell adhesion molecules. This immunomodulatory property was proposed that one of the possible action mechanisms of extract. An improvement in intestinal damage was also associated with a reduction in oxidative stress and infiltration of leukocytes, as evidenced by the reduction in malonaldialdehyde and myeloperoxidase activity and increase in total glutathione in the colonic tissue. Moreover, the extract improved the cytoarchitecture of the colonic tissue and the integrity of the intestinal epithelial barrier by restoring the expression of the proteins associated with mucosa protection. In view of the beneficial effects showed by the B. pinnatum leaf extract in preclinical rodent models of colitis there is the potential to conduct some future clinical studies to ensure safe and effective development of a phytotherapeutic treatment for human inflammatory bowel diseases.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anti-Inflammatory and Chemopreventive Effects of Bryophyllum pinnatum (Lamarck) Leaf Extract in Experimental Colitis Models in Rodents

et al. 2020

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“…Oken (B. pinnatum), native to Madagascar, is important in the therapeutic context since it is widely used to treat inflammation conditions (Panyaphu et al, 2011;Ezuruike and Prieto, 2014;Sreekeesoon and Mahomoodally, 2014). Botanic synonyms as Bryophyllum calycinum and Kalanchoe pinnata can be found (Fernandes et al, 2019). This species is rich in phenolic compounds, particularly flavonoids (Nascimento et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the 3-O diglycosidic bond and the dimer rhamnosearabinose are not common structure features and this flavonoid was described for few other species from different botanical families, however not as their major compound (Fernandes et al, 2019). Therefore, the compound 1 may be considered a promising chemical marker of the extract of B. pinnatum, making it also important to the conduction of deeper studies aiming to investigate its biological activities (dos Santos Nascimento et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Identification of a Selective PDE4B Inhibitor From Bryophyllum pinnatum by Target Fishing Study and In Vitro Evaluation of Quercetin 3-O-α-L-Arabinopyranosyl-(1→2)-O-α-L-Rhamnopyranoside

et al. 2020

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Natural products are considered an important source of bioactive compounds especially in biodiversity-rich countries like Brazil. The identification of potential targets is crucial to the development of drugs from natural sources. In this context, in silico methodologies, such as inverse virtual screening (target fishing), are interesting tools as they are a rational and direct method that reduces costs and experimental time. Among the species of Brazilian biomes, Bryophyllum pinnatum (Lam.) Oken, native to Madagascar, is widely used by the population to treat inflammation conditions. It has a remarkable presence of flavonoids, including quercetin 3-O-a-L-arabinopyranosyl-(1!2)-O-a-Lrhamnopyranoside (1), considered one of its major compounds. However, until now there were no studies addressing its putative mechanism of action and explaining its pharmacological action. The enzyme PDE4B, known as an antiinflammatory protein, was indicated as a promising target by target fishing methods. This activity was confirmed by in vitro enzymatic inhibition, and an expressive selectivity of PDE4B over PDE4A was demonstrated. The interactions were investigated through molecular dynamics simulations. The results were pioneering, representing an advance in the investigation of the antiinflammatory action of B. pinnatum and confirm the potential of the flavonoid as a chemical extract marker. Also, the flavonoid was shown to be a promising lead for the design of other selective PDE4B blockers to treat inflammatory diseases.

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Exploring the Pharmacognostical and Phytochemical Profiles of Aqueous Extracts of Kalanchoe

Machinski,

Andrade,

Schaffka

et al. 2024

Chemistry & Biodiversity

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The use of plants for medicinal purposes has a long history, however it is desirable a continuous evaluation seeking for complementary scientific evidences for their safe application. Species within the Kalanchoe genus are often referred to as "miracle leaf" due to their remarkable healing properties. Traditionally, these plants have been used to treat infections, inflammation, and cancer. Despite their widespread use, the identification of their active components remains incomplete. This study aimed to differentiate K. crenata (KC), K. marmorata (KM), and K. pinnata (KP) by conducting detailed histochemical and phytochemical analyses, and to assess their antioxidant capabilities. The investigation revealed significant differences between the species, highlighting the variability in phenolic (PC) and flavonoid contents (FC) and their distinct antioxidant effects. The KM demonstrated the greatest results (PC: 59.26 ± 1.53 mgEqGA/g; FC: 12.63 ± 0.91 mgEqCQ/g; DPPH• (IC50): 110.66 ug/ml; ABTS•+ (IC50): 26.81 ug/ml; ORAC: 9.65 ± 0.75 mmolTE) when compared to KC and KP. These findings underscore a new reference for research within the Kalanchoe genus.

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Kalanchoe laciniata and Bryophyllum pinnatum: an updated review about ethnopharmacology, phytochemistry, pharmacology and toxicology

Cited by 55 publications

References 181 publications

Anti-Inflammatory and Chemopreventive Effects of Bryophyllum pinnatum (Lamarck) Leaf Extract in Experimental Colitis Models in Rodents

Anti-Inflammatory and Chemopreventive Effects of Bryophyllum pinnatum (Lamarck) Leaf Extract in Experimental Colitis Models in Rodents

Identification of a Selective PDE4B Inhibitor From Bryophyllum pinnatum by Target Fishing Study and In Vitro Evaluation of Quercetin 3-O-α-L-Arabinopyranosyl-(1→2)-O-α-L-Rhamnopyranoside

Exploring the Pharmacognostical and Phytochemical Profiles of Aqueous Extracts of Kalanchoe

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