Protective effect of Schisandra chinensis total lignans on acute alcoholic-induced liver injury related to inhibiting CYP2E1 activation and activating the Nrf2/ARE signaling pathway

Su, Lianlin; Li, Ping; Lu, Tu-Lin; Mao, Chunqin; Ji, De; Hao, Min; Huang, Zhegang

doi:10.1016/j.bjp.2019.01.008

Cited by 18 publications

(9 citation statements)

References 30 publications

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“…For example, Wang et al [ 124 ] observed that lignans-enriched SC extracts (Schizandrol A and Schizandrol B) significantly ameliorated alcohol-induced liver damage by improving serum and liver biomarkers in male ICR mice exposed to 50% ( v / v ) alcohol for 60 days. Similarly, a recent study conducted by Su et al [ 125 ] also found a surprising effect of SC against ALD. Daily administration of SC (400 and 800 mg/kg bw) for 14 days significantly ameliorated alcohol-induced liver damage in rats by suppressing CYP2E1 activation and activating the Nrf2/antioxidant response element signaling pathway.…”

Section: Bioactive Compounds Ameliorate Ald Via Multiple Pathwayssupporting

confidence: 54%

Protective Mechanism of Edible Food Plants against Alcoholic Liver Disease with Special Mention to Polyphenolic Compounds

et al. 2021

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Alcoholic liver disease (ALD) is one type of liver disease, causing a global healthcare problem and mortality. The liver undergoes tissue damage by chronic alcohol consumption because it is the main site for metabolism of ethanol. Chronic alcohol exposure progresses from alcoholic fatty liver (AFL) to alcoholic steatohepatitis (ASH), which further lead to fibrosis, cirrhosis, and even hepatocellular cancer. Therapeutic interventions to combat ALD are very limited such as use of corticosteroids. However, these therapeutic drugs are not effective for long-term usage. Therefore, additional effective and safe therapies to cope with ALD are urgently needed. Previous studies confirmed that edible food plants and their bioactive compounds exert a protective effect against ALD. In this review article, we summarized the hepatoprotective potential of edible food plants and their bioactive compounds. The underlying mechanism for the prevention of ALD by edible food plants was as follows: anti-oxidation, anti-inflammation, lipid regulation, inhibition of apoptosis, gut microbiota composition modulation, and anti-fibrosis.

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Section: Bioactive Compounds Ameliorate Ald Via Multiple Pathwayssupporting

confidence: 54%

Protective Mechanism of Edible Food Plants against Alcoholic Liver Disease with Special Mention to Polyphenolic Compounds

et al. 2021

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“…Especially, S. chinensis and H. dulcis have been used as a key ingredient herb for treating alcohol detoxification in Korean and Chinese traditional medicine [ 15 , 16 ]. The ethnopharmacological evidence has prompted research about the hepatoprotective effect of SF and HSCF against ALD [ 12 , 17 , 32 ]. In previous study, we evaluated the hepatoprotective effect fSFP and HSCF ( w : w ; 1:1, 1:2, 1:4, 1:6, 2:1, 4:1, 6:1 and 8:1) mixtures at different ratios to develop a novel functional food for preventing liver disease [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Synergistic Protective Effect of Fermented Schizandrae Fructus Pomace and Hoveniae Semen cum Fructus Extracts Mixture in the Ethanol-Induced Hepatotoxicity

Jegal

Park

Choi³

et al. 2023

Antioxidants

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Schizandrae Fructus (SF), fruits of Schisandra chinensis (Turcz.) Baill. and Hoveniae Semen cum Fructus (HSCF), the dried peduncle of Hovenia dulcis Thunb., have long been used for alcohol detoxification in the traditional medicine of Korea and China. In the current study, we aimed to evaluate the potential synergistic hepatoprotective effect of a combination mixture (MSH) comprising fermented SF pomace (fSFP) and HSCF hot water extracts at a 1:1 (w:w) ratio against ethanol-induced liver toxicity. Subacute ethanol-mediated hepatotoxicity was induced by the oral administration of ethanol (5 g/kg) in C57BL/6J mice once daily for 14 consecutive days. One hour after each ethanol administration, MSH (50, 100, and 200 mg/kg) was also orally administered daily. MSH administration significantly reduced the serum activities of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and γ-glutamyl transpeptidase. Histological observation indicated that MSH administration synergistically and significantly decreased the fatty changed region of hepatic parenchyma and the formation of lipid droplet in hepatocytes. Moreover, MSH significantly attenuated the hepatic triglyceride accumulation through reducing lipogenesis genes expression and increasing fatty acid oxidation genes expression. In addition, MSH significantly inhibited protein nitrosylation and lipid peroxidation by lowering cytochrome P450 2E1 enzyme activity and restoring the glutathione level, superoxide dismutase and catalase activity in liver. Furthermore, MSH synergistically decreased the mRNA level of tumor necrosis factor-α in the hepatic tissue. These findings indicate that MSH has potential for preventing alcoholic liver disease through inhibiting hepatic steatosis, oxidative stress, and inflammation.

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“…In traditional medicine, the berry extracts of S. chinensis are considered as both tonic and liver protective agents and they are currently referred as adaptogens. 59 In Traditional Chinese Medicine (TCM), schisandra berries are plants that belong to the 'Herbs that stabilize and bind' category. This category of herbs is used for treating abnormal discharges and displacement of organs.…”

Section: Health Benefits In Modern and Traditional Science Traditional Medicinementioning

confidence: 99%

Schisandra chinensis, Five Flavor Berry, a Traditional Chinese Medicine and a Super-Fruit from North Eastern China

Sun¹,

Shahrajabian²,

Cheng³

2021

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Introduction:The aim of this review was to summarize the most important traditional and modern health benefits of Schisanda berry. Methods: We used PubMed, Science Direct and Google to search for and collect scientific publication for a full evaluation of current evidence in the literature indicating the potential role of Schisanda berry. Results: The traditional Chinese medicine (TCMs) is essential components of alternative medicines. Schisandra berry (Schisandra chinensis (Turcz.) Baill. (Magnoliaceae) or Wu-Wei-Zi, which means the fruit of five tastes is a commonly used herb in traditional Chinese medicine (TCM). The five tastes of Schisandra berry refer to its influence on the five visceral organs in the body. It is one of the oldest medicinal plants used in East of Asia, especially traditional Chinese medicine. S. chinensis is mainly distributed in provinces in northern China including Heilongjiang, Jilin and Liaoning. S. chinensis can treat lung-Qi and kidney-Yin deficiencies, relieve coughs and asthma and stop persistent diarrhea. S. chinensis has been used to treat sleep disorder in traditional Chinese medicine and a tonic for kidney and brain in traditional Chinese medicine. Its extracts may apply as a preservative and as an additive to increase the flavor, taste and nutritional value of food. The five important components of S. chinensis are Schisandrol B, Schisandrin A, γ-Schisandrin, Gomisin N and Schisandrin C. Conclusion:The most important pharmacological effects of Schisandrol B are antiallergy, liver protection and anticarcinogenic effects; Schisandrin A has role in liver protection and anti-carcinogenic effect; γ-Schisandrin has liver protection and anti-carcinogenic effect, Gomisin N has anti-proliferative, pro-apoptis HepG2 cells, anti-hepatitis, anti-HIV, anti-carcinogenic effect; and Schisandrin C has protect liver, anti-HIV, anti-catchinogenic effect and anti-hepatitis. The treatment with natural herbal medicine which are also super-fruit and non-synthetic drug is recommended.

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Protective effect of Schisandra chinensis total lignans on acute alcoholic-induced liver injury related to inhibiting CYP2E1 activation and activating the Nrf2/ARE signaling pathway

Cited by 18 publications

References 30 publications

Protective Mechanism of Edible Food Plants against Alcoholic Liver Disease with Special Mention to Polyphenolic Compounds

Protective Mechanism of Edible Food Plants against Alcoholic Liver Disease with Special Mention to Polyphenolic Compounds

Synergistic Protective Effect of Fermented Schizandrae Fructus Pomace and Hoveniae Semen cum Fructus Extracts Mixture in the Ethanol-Induced Hepatotoxicity

Schisandra chinensis, Five Flavor Berry, a Traditional Chinese Medicine and a Super-Fruit from North Eastern China

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