An eco-friendly method for extraction and quantification of flavonoids in Dysphania ambrosioides

Ferreira, Thaís M.S.; Santos, Júlia A. dos; Modesto, Leandra A.; Souza, L.S.; Santos, Maria Patrícia V. dos; Bezerra, Debborah Gonçalves; Paula, Joelma Abadia Marciano de

doi:10.1016/j.bjp.2019.01.004

Cited by 11 publications

(5 citation statements)

References 7 publications

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“…Ultrasonic-assisted ionic liquid extraction (UAILE), a new green extraction approach, can more effectively extract target components from natural products, which can establish a method that has many advantages such as time-saving, simple operation, safety, and high extraction efficiency, and is suitable for the extraction of biflavonoids. − Kou and colleagues used IL-ultrasonic-assisted extraction (UAILE) to extract turmeric polysaccharides from ginger, with a yield of 92.82%. Compared with traditional methods, UAILE not only significantly increased the yield of turmeric polysaccharides but also shortened the extraction time.…”

Section: Introductionmentioning

confidence: 99%

Ultrasonic-Assisted Ionic Liquid Extraction of Two Biflavonoids from Selaginella tamariscina

Jiang

Wang

et al. 2020

ACS Omega

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Selaginella tamariscina, a traditional Chinese medicine, contains a variety of bioactive components, among which biflavonoids are the main active ingredients and have antioxidant, antitumor, and anti-inflammatory properties. In this study, ultrasonic-assisted ionic liquid extraction (UAILE) is used for the first time to extract two main biflavonoids (amentoflavone (AME) and hinokiflavone (HIN)) from S. tamariscina. A high-performance liquid chromatography method is used for the simultaneous determination of AME and HIN in S. tamariscina. Then, three novel ILs are synthesized for the first time by a one-step method using benzoxazole and three acids or acid salts as raw materials, and the structures of the synthesized ILs are characterized by elemental analysis, infrared spectroscopy, and NMR spectroscopy, as well as the thermal stability of the ILs is evaluated by thermogravimetric analysis. After screening the extraction effects of three benzoxazole ILs, three pyridine ILs, and three imidazole ILs, it is found that [Bpy]BF 4 is the best and therefore selected as the extractant. The optimal extraction process is explored in terms of the yields of AME and HIN from S. tamariscina by a single-factor experiments and response surface analysis. Under the optimal level of each influencing factor (IL concentration of 0.15 mol/L, solid−liquid ratio of 1:12 g/mL, ultrasonic power of 280 W, ultrasonic time of 30 min, and three extraction cycles), the extraction rates of AME and HIN from S. tamariscina are 13.51 and 6.74 mg/g, respectively. Moreover, the recovery experiment of [Bpy]BF 4 on the extraction of biflavonoids shows that the recovered IL can repeatedly extract targets six times and the extraction rate is about 90%, which indicates that the IL can be effectively reused. UAILE can effectively and selectively extract AME and HIN, laying the foundation for the application of S. tamariscina.

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Section: Introductionmentioning

confidence: 99%

Ultrasonic-Assisted Ionic Liquid Extraction of Two Biflavonoids from Selaginella tamariscina

Jiang

Wang

et al. 2020

ACS Omega

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“…This proposed method was compared to some published methods for extracting flavonoids. 43–45 As can be seen from Table 3, this method had the advantage of a shorter extraction time compared with Soxhlet extraction. Compared to ultrasonic-assisted extraction and microwave-assisted extraction, this method avoided the use of a toxic solvent and had satisfactory recovery.…”

Section: Resultsmentioning

confidence: 99%

Application of an alkali destruction technique and natural deep eutectic solvent for greener extraction from peanut shells: optimization and extraction kinetics study

et al. 2022

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“…According to Ferreira et al (2019), flavonoids, as rutin equivalent, are abundantly found in the aerial parts of D. ambrosioides rather than other phenolic compounds. This study has been done through spectrophotometric analytical methods.…”

Section: Extractmentioning

confidence: 99%

A Review of Botany, Phytochemical, and Pharmacological Effects of Dysphania ambrosioides

Hewis

Daeli

Tanoto

et al. 2020

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Traditional medicine is widely used worldwide due to its benefits and healthier components that these natural herbs provide. Natural products are substances produced or retrieved from living organisms found in nature and often can exert biological or pharmacological activity, thus making them a potential alternative for synthetic drugs. Natural products, especially plant-derived products, have been known to possess many beneficial effects and are widely used for the treatment of various diseases and conditions. Dysphania ambrosioides is classified as an annual or short-lived perennial herb commonly found in Central and South America with a strong aroma and a hairy characteristic. Major components in this herb are ascaridole, p-cymene, α-terpinene, terpinolene, carvacrol, and trans-isoascaridole. Active compounds isolated from this herb are found to exert various pharmacological effects including schistosomicidal, nematicidal, antimalarial, antileishmanial, cytotoxic, antibacterial, antiviral, antifungal, antioxidant, anticancer, and antibiotic modulatory activity. This review summarizes the phytochemical compounds found in the Dysphania ambrosioides, together with their pharmacological and toxicological effects.

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An eco-friendly method for extraction and quantification of flavonoids in Dysphania ambrosioides

Cited by 11 publications

References 7 publications

Ultrasonic-Assisted Ionic Liquid Extraction of Two Biflavonoids from Selaginella tamariscina

Ultrasonic-Assisted Ionic Liquid Extraction of Two Biflavonoids from Selaginella tamariscina

Application of an alkali destruction technique and natural deep eutectic solvent for greener extraction from peanut shells: optimization and extraction kinetics study

A Review of Botany, Phytochemical, and Pharmacological Effects of Dysphania ambrosioides

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