Brazilian stingless bee propolis and geopropolis: promising sources of biologically active compounds

Lavinas, Flávia Conde; Macedo, Ellis Helena B.C.; Sá, Gabriel B.L.; Amaral, Ana Cláudia F.; Silva, Jefferson Rocha de Andrade; Azevedo, Mariana M. B.; Vieira, Bárbara A.; Domingos, Thaisa Francielle Souza; Vermelho, Alane Beatriz; Carneiro, Carla da Silva; Rodrigues, Igor A.

doi:10.1016/j.bjp.2018.11.007

Cited by 91 publications

(104 citation statements)

References 65 publications

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“…The Brazilian green propolis rich in artepillin C has revealed superior wound healing activity with respect to Brazilian red propolis (Batista et al 2012). Regarding the geopropolis of the jandaíra stingless bee, no wound healing activity has been described, but the geopropolis of native bees exhibit immunomodulatory, analgesic, antileishmanial, and antimicrobial properties (Liberio et al 2011;Cunha et al, 2013;Dutra et al 2019;Lavinas et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Wound healing activity and chemical composition of geopropolis from Melipona subnitida

Sousa-Fontoura

Olinda

Viana

et al. 2020

Rev. Bras. Farmacogn.

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Geopropolis collected by stingless bees is a product widely used in the semiarid Northeast region of Brazil. The wound healing activity, palynological analysis, free-radical scavenging activities, and the chemical composition of the hydroalcoholic extract of six samples from jandaíra geopropolis were determined. The wound healing activity was evaluated using 10% geopropolis hydroalcoholic extract added to the formulation incorporated into a base of Lannette cream, and the chemical composition of six samples was determinate by ultra-performance liquid chromatography coupled with diode array and quadrupole time-offlight mass spectrometry. The detected compounds in the five samples (1-5) were classified as flavonoid aglycones (flavonols, flavanonols, flavonones, flavones, and chalcones). In sample 6, flavonoids, phenylpropanoids, and hydrolysable tannins were identified. Analysis of the pollen types in geopropolis showed that pollen from Leguminosae was predominant, indicating the visit of bees in the species of this family. This sample (6), with the highest content of phenolic compounds and high freescavenging activity, was tested to evaluate the wound healing potential. The topical application of geopropolis (10%) increased the wound healing rate and re-epithelialization of wounds in rats. Our data indicate that the mixture of phenolic components in the geopropolis may contribute to the activities of free-radical scavenging and wound healing.

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Section: Introductionmentioning

confidence: 99%

Wound healing activity and chemical composition of geopropolis from Melipona subnitida

Sousa-Fontoura

Olinda

Viana

et al. 2020

Rev. Bras. Farmacogn.

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“…The percentages of stingless bee products in the beehive are still unknown; it supposed to be varied according to the species. Generally, propolis is main content of stingless bee hive, regardless the species, as the hive is constructed with it [ 17 ]. A study on nine Trigona species reported that the hive products of those species were 63.7% propolis, 20.9% beebread and 15.4% honey [ 18 ].…”

Section: Harvesting and Characterization Of Stingless Bee Productsmentioning

confidence: 99%

“…Ethanol extracts of SBP showed antioxidant activity as they were able to scavenge free radicals in vitro and also protected erythrocytes by inhibiting oxidative hemolysis [ 51 ]. Despite some controversial reports regarding the toxic potential of SBP, Levinas et al have performed in silico toxicity analysis involved a total of 35 SBP phenolic compounds [ 17 ]. The analysis showed that these compounds revealed low toxicity, which means that SBP is safe and not considered as a toxic product, whereas more pre-clinical studies are still required to confirm these findings.…”

Section: Stingless Bee Propolis (Sbp)mentioning

confidence: 99%

Antioxidant-Based Medicinal Properties of Stingless Bee Products: Recent Progress and Future Directions

et al. 2020

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Stingless bees are a type of honey producers that commonly live in tropical countries. Their use for honey is being abandoned due to its limited production. However, the recent improvements in stingless bee honey production, particularly in South East Asia, have brought stingless bee products back into the picture. Although there are many stingless bee species that produce a wide spread of products, known since old eras in traditional medicine, the modern medical community is still missing more investigational studies on stingless bee products. Whereas comprehensive studies in the current era attest to the biological and medicinal properties of honeybee (Apis mellifera) products, the properties of stingless bee products are less known. This review highlights for the first time the medicinal benefits of stingless bee products (honey, propolis, pollen and cerumen), recent investigations and promising future directions. This review emphasizes the potential antioxidant properties of these products that in turn play a vital role in preventing and treating diseases associated with oxidative stress, microbial infections and inflammatory disorders. Summarizing all these data and insights in one manuscript may increase the commercial value of stingless bee products as a food ingredient. This review will also highlight the utility of stingless bee products in the context of medicinal and therapeutic properties, some of which are yet to be discovered.

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“…No caso das abelhas indígenas sem ferrão do Gênero Meliponinae (KERR, 1987) e Scaptotrigona, além do material resinoso das plantas, elas misturam, cera com solo ou argila (BOGDANOV, 2016), razão da denominação de geoprópolis. Essa mistura, também serve para construir os ninhos(KERR, 1987;LAVINAS et al, 2018).…”

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“…Como os compostos fenólicos são responsáveis pelo efeito antioxidante atribuído a própolis de abelhas africanizadas da região sudeste e nordeste do Brasil, dentre os mais encontrados, estão os derivados do ácido cinâmico (RUFATTO et al, 2017), e também alguns compostos em meliponineos (LAVINAS et al, 2018), supõe-se que esse elementos também sejam identificados no geoprólis da ASF que por sua vez depende do ecosistema.Assim, sugere-se mais pesquisas para investigar tanto a ação e composição dos compostos fenólicos do geopróplis S. bipunctata uma vez que os efeitos da geoprópolis dependem diretamente da sua composição química. Como essa composição é muito variada, alguns fatores interferem na atividade biológicas, como, época de colheita, ecoflora local e a genética das abelhas (BOGDANOV, 2016;LAVINAS et al, 2018)…”

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Ocorrência de desoxinivalenol em farinha de trigo: Revisão

Rocha¹,

Oliveira²

2019

Ciência E Tecnologia Dos Alimentos–Volume 3

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Brazilian stingless bee propolis and geopropolis: promising sources of biologically active compounds

Cited by 91 publications

References 65 publications

Wound healing activity and chemical composition of geopropolis from Melipona subnitida

Wound healing activity and chemical composition of geopropolis from Melipona subnitida

Antioxidant-Based Medicinal Properties of Stingless Bee Products: Recent Progress and Future Directions

Ocorrência de desoxinivalenol em farinha de trigo: Revisão

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