Anti-allergic rhinitis effects of caffeoylquinic acids from the fruits of Xanthium strumarium in rodent animals via alleviating allergic and inflammatory reactions

Peng, Wei; Han, Ping; Yu, Li; Chen, Ying; Ye, Bingzhu; Qin, Lu-Ping; Xin, Hailiang; Han, Ting

doi:10.1016/j.bjp.2018.10.004

Cited by 20 publications

(6 citation statements)

References 26 publications

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“…Methanolic as well as aqueous extracts of several plant parts from different Xanthium species, in different animal models, were also reported to lower oxidative stress and proinflammatory marker levels. As such, a possible mechanism for the anti-inflammatory effect is related to the inhibitory action on NF-kB, STAT1, and MAPK activation and consequently to the reduced secretion of proinflammatory cytokines [ 3 , 27 , 28 , 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Influences of Different Extraction Techniques and Their Respective Parameters on the Phytochemical Profile and Biological Activities of Xanthium spinosum L. Extracts

Gligor

Clichici

Moldovan

et al. 2022

Plants

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The aim of this study was to identify possible influences of extraction methods as well as extraction parameters on the phytochemical and biological profiles of Xanthium spinosum L. extracts. Extraction methods were chosen as follows: classical methods, maceration and Soxhlet extraction; innovative extraction methods, turboextraction, ultrasound-assisted extraction, and a combination of the latter two. Extracts were subjected to total polyphenolic and flavonoid content spectrophotometric analysis. The phytochemical profile was determined for the best-yielding extracts using HPLC-MS analysis. Following the newly acquired data, another sorting of the extracts was performed. Biological activities such as antimicrobial and anti-inflammatory actions were evaluated, as well as oxidative stress reduction potential, on a Wistar rats inflammation model. Comparable results were achieved with Soxhlet extraction and ultrasound-assisted extraction, both surpassing all other tested methods in terms of yields. Bioactive compound concentrations tended to increase with the increase in extraction time and temperature. These maximal values lowered once the degradation points of the bioactive compounds were reached. Extracts demonstrated good protection against Gram-negative bacteria. Additionally, they provided good cellular protection and increased the antioxidant defense in the analyzed rat plantar tissue.

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Section: Discussionmentioning

confidence: 99%

Influences of Different Extraction Techniques and Their Respective Parameters on the Phytochemical Profile and Biological Activities of Xanthium spinosum L. Extracts

Gligor

Clichici

Moldovan

et al. 2022

Plants

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“…Although the techniques for diagnosing and treating diseases have significantly improved, the treatment of allergic diseases is still very difficult in modern medicine [24,25]. As a complex chronic inflammatory airway disease, allergic asthma involves a variety of inflammation cell types and molecules, such as eosinophils, lymphocytes, chemokines and cytokines, etc.…”

Section: Discussionmentioning

confidence: 99%

Purification, Characterization of Two Polysaccharides from Pinelliae Rhizoma Praeparatum Cum Alumine and Their Anti-Inflammatory Effects on Mucus Secretion of Airway Epithelium

Liu

Wang

et al. 2019

IJMS

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Pinelliae Rhizoma Praeparatum cum Alumine (PRPCA) is an important traditional processed herbal medicine mainly used for treating phlegm in China for more than 2000 years. In our previous studies, extraction optimization, characterization, and bioactivities of total polysaccharides from PRPCA were investigated. In this study, further purification of these polysaccharides was performed. Two polysaccharides named neutral fraction of total polysaccharides-II (TPN-II) and acidic fraction of total polysaccharides-II (TPA-II) were obtained by gradient ion-exchange chromatography followed by gel-permeation chromatography. Results of scanning electron microscopy (SEM) analysis in the present study showed that TPN-II had a tight structure with a rough and uneven surface, while TPA-II had a relative homogeneous surface and a loose structure. Further studies indicated that TPN-II was a homosaccharide mainly composed by glucose with a molecular weight of 8.0 kDa. TPA-II was mainly composed of mannose, rhamnose, glucuronic acid, galacturonic acid, glucose, galactose and arabinose in a molar ratio of 2.1, 2.3, 1.7, 10.6, 2.6, 14.2, and 2.5, with a molecular weight of 1250 kDa. The nuclear magnetic resonance (NMR) results indicated that α and β form glycoside bonds existed in TPN-II and TPA-II, and TPN-II was composed of α-glucopyranose. In addition, both purified polysaccharides have significant anti-inflammatory effects on mucus secretion of human airway epithelial NCI-H292 cells without cytotoxicity. Compared with TPN-II, TPA-II exhibited more significant anti-inflammatory effects on lipopolysaccharide (LPS)-induced airway inflammation by regulating levels of interleukin-4 (IL-4) and interferon-γ (IFN-γ) and inhibiting mucus secretion. The results suggest that polysaccharides from PRPCA could be explored as therapeutic agents in treating inflammation and over secretion of mucus in asthma.

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“…[19] Phenylpropanoids Phenylpropanoids are one of the characteristic constituents in Cinnamomi ramulus, which possess various bioactive effects, such as antitumour, antioxidant, anti-inflammatory and neuroprotective activities. [20][21][22] In this paper, we summarized 34 phenylpropanoid compounds isolated from the Cinnamomi ramulus, including cinnamic alcohol (1), cinnamic acid (2), [23] trans-O-methoxy cinnamic acid (3), trans-O-hydroxy cinnamic acid (4), [24] 2-hydroxy-cinnamyl alcohol (5), [25] cinnamaldehyde (6), [23] 2-hydroxyl cinnamaldehyde (7), 2-methoxy cinnamaldehyde (8), 4-methoxycinnamaldehyde (9), [26] coniferaldehyde (10), [27] dihydromelilotoside (11), methyl dihydromelilotoside (12), [28] balanophonin (13), hierochin B (14), [29] coumarin (15), [23] phenethyl (E)-3-[4-methoxyphenyl]-2-propenoate (16) [25] and eugenol (17). [30] A previous study in 2004 evidenced that eugenol exhibited antibacterial activity by inhibiting energy generation of bacteria.…”

Section: Traditional Usesmentioning

confidence: 99%

The traditional uses, phytochemistry, pharmacology and toxicology of Cinnamomi ramulus: a review

Liu

Zhang

et al. 2019

Journal of Pharmacy and Pharmacology

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Objectives Cinnamomi ramulus (called Guizhi in Chinese) is a traditional medicine used to treat gastrointestinal dysfunction, cancer, arthritis, osteoporosis, spleen deficiency, Alzheimer's disease and obesity. This review aimed to provide a systematic summary on the geographical distribution, botany, traditional application, phytochemistry, pharmacology, pharmacokinetics, toxicology and other aspects of Cinnamomi ramulus. Key finding So far, more than 121 chemical compounds have been isolated from Cinnamomi ramulus, including volatile oil, organic acids, triterpenoid saponins, coumarins, tannins, flavonoids and flavonoid glycosides, steroids and polysaccharides. This paper reviews the pharmacological effects of Cinnamomi ramulus on antibacterial, anti-inflammatory, antiviral, antitumour, antipyretic and analgesic, antidiabetic and antiplatelet aggregation effects. Furthermore, the present review also indicates that Cinnamomi ramulus has the potential to develop into drugs for treating various diseases with high efficacy and low toxicity. Summary The convictive evidence from modern pharmacology research supports the traditional application of Cinnamomi ramulus. However, further studies on the structure-activity relationship of some of the isolated compounds may improve their biological potency. More toxicological studies will also contribute to the progress of clinical trial studies.

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Anti-allergic rhinitis effects of caffeoylquinic acids from the fruits of Xanthium strumarium in rodent animals via alleviating allergic and inflammatory reactions

Cited by 20 publications

References 26 publications

Influences of Different Extraction Techniques and Their Respective Parameters on the Phytochemical Profile and Biological Activities of Xanthium spinosum L. Extracts

Influences of Different Extraction Techniques and Their Respective Parameters on the Phytochemical Profile and Biological Activities of Xanthium spinosum L. Extracts

Purification, Characterization of Two Polysaccharides from Pinelliae Rhizoma Praeparatum Cum Alumine and Their Anti-Inflammatory Effects on Mucus Secretion of Airway Epithelium

The traditional uses, phytochemistry, pharmacology and toxicology of Cinnamomi ramulus: a review

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