Isocryptolepine, an indoloquinoline alkaloid from Cryptolepis sanguinolenta promotes LDL uptake in HepG2 cells

Aggrey, Mike Okweesi; Li, Hui; Wang, Wen-Qiong; Song, Wenli; Wang, Yiping; Liu, Xuan

doi:10.1016/j.bjp.2018.08.008

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…A vast pool of indole derivatives, both naturally occurring [ 1 ] and synthetic [ 2 ], have long been a valuable source of potential leads for novel therapeutics, as the majority of indoles are biologically active exhibiting, among others, antitumor [ 3 ], anti-Alzheimer’s [ 4 ], antiviral [ 5 ], antituberculosis [ 6 ], antimalarial [ 7 ] and antibacterial [ 8 ] properties. In this context, a subclass of polynuclear indoles, such as cryptolepine [ 9 ], isocryptolepine 1 [ 10 , 11 ] and neocryptolepine [ 12 ] alkaloids or paullone 2 derivatives [ 13 ], stand somewhat alone, because their preparation usually involves time-consuming, multi-step synthetic procedures ( Figure 1 ). Nevertheless, as such multicyclic skeletons are frequently part of bioactive natural substances, there is significant scientific interest toward them.…”

Section: Introductionmentioning

confidence: 99%

One-Pot Synthesis of Polynuclear Indole Derivatives by Friedel–Crafts Alkylation of γ-Hydroxybutyrolactams

Абаев

Аксенов

et al. 2023

Molecules

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Section: Introductionmentioning

confidence: 99%

One-Pot Synthesis of Polynuclear Indole Derivatives by Friedel–Crafts Alkylation of γ-Hydroxybutyrolactams

Абаев

Аксенов

et al. 2023

Molecules

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“…Likewise isocryptolepine, an important anti‐hyperlipidemic natural indoloquinoline alkaloid valuable for the treatment of atherosclerotic cardiovascular disease (Aggrey et al, 2018). As this aspect, Rodphon et al (2021) demonstrated a series of 3‐isocryptolepine‐1,2,3‐triaoles 62 in 36%–90% yields using the click‐reaction approach as shown in path A , Scheme 15.…”

Section: Synthetic Strategiesmentioning

confidence: 99%

Comprehensive review on natural pharmacophore tethered 1,2,3‐triazoles as active pharmaceuticals

Rammohan

Venkatesh²,

Basha

et al. 2022

Chem Biol Drug Des

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The privileged 1,2,3‐triazole scaffold is drawing researcher's attention due to its widespread applications in diverse fields such as drug discovery (e.g., carboxyamidotriazole), organic synthesis (click‐reaction template), polymeric materials (e.g., triazolamer), supramolecular receptors (e.g., triazolophane), fluorescent materials (e.g., metal–organic frameworks), and agricultural sectors (e.g., fungicides). Various 1,2,3‐triazole persuasion modules are also currently available in the market that have multiple assets such as active pharmaceuticals and agricultural purposes. Owed to the highly consistent and firmest synthesis approach, that is, click reaction of various azides and acetylene derivatives by copper (I)‐catalyzed 1,3‐dipolar cycloaddition (CuAAC), highly functionalized 1,2,3‐triazoles are prepared in scalar yields for drug discovery. Given the importance of 1,2,3‐triazole chemistry, the present review focuses specifically on the synthesis of structurally diverse 1,2,3‐triazoles linked to natural pharmacophores and their biological importance. Furthermore, the dual/multi‐pharmacophores assimilated 1,2,3‐triazoles have listed interesting biological activities that could be valuable as future drug leads. In addition, this comprehensive review can serve as a template for the development of new diverse scaffolds that will ensure for new therapeutic approaches for the existing myriad diseases and disorders.

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“…It is mostly used for the treatment of malaria although it has other pharmacological properties. They include anti-bacterial 7 , anti-viral, anti-inflammatory 8 , antidiabetic and hypotensive effects [9][10][11] . Recently, alkaloids from C. sanguinolenta have been reported to represent a promising class of compounds that could serve as lead compounds in the search for a cure for coronavirus disease.…”

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confidence: 99%

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2022

IJPSR

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Concurrent administration of herbal medicines and conventional drugs is a common practice globally, especially as the patronage of medicinal plants increases across the world. This study aimed to determine the effect of Cryptolepis sanguinolenta administration on the metabolism of chloroquine by evaluating specific Cytochrome P450 isozymes. Reconstituted freeze dried Cryptolepis sanguinolenta was administered to male Sprague-Dawley rats in drinking water for 2 weeks at a dose of 36mg/kg, followed by a single dose of chloroquine (15mg/kg). All the animals were sacrificed by cervical dislocation after 24 h of final drug administration, and the liver was excised for hepatic microsomes preparation. Using the microsomes, the PNPH, AmD and NOD activities were determined as a measure of CYP2E1, CYP2B1 and CYP1A activities, respectively. The study showed that concurrent administration of chloroquine and Cryptolepis sanguinolenta impaired the CYP-mediated metabolism of chloroquine due to competitive inhibition of CYP2B1 by C. sanguinolenta. However, concurrent administration of chloroquine and Cryptolepissanguinolenta showed no significant effect on CYP2E1 and CYP1A. Patients should be advised on the clinical consequence of concurrent administering Cryptolepis sanguinolenta-based herbal products and chloroquine. INTRODUCTION:Chloroquine is a synthetic 4aminoquinoline, used for many decades in the prophylaxis and treatment of malaria caused by Plasmodium vivax (P. vivax), P. ovale, P. malaria and the sensitive strains of P. falciparum 1 . Despite resistant P. falciparum strains, chloroquine remains a key antimalarial drug used alone or in combination with other drugs as the first-line treatment for malaria due to its low cost, tolerance, and availability 2 .

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Isocryptolepine, an indoloquinoline alkaloid from Cryptolepis sanguinolenta promotes LDL uptake in HepG2 cells

Cited by 5 publications

References 18 publications

One-Pot Synthesis of Polynuclear Indole Derivatives by Friedel–Crafts Alkylation of γ-Hydroxybutyrolactams

One-Pot Synthesis of Polynuclear Indole Derivatives by Friedel–Crafts Alkylation of γ-Hydroxybutyrolactams

Comprehensive review on natural pharmacophore tethered 1,2,3‐triazoles as active pharmaceuticals

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