2019
DOI: 10.1016/j.bjp.2018.07.009
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Toona sinensis: a comprehensive review on its traditional usages, phytochemisty, pharmacology and toxicology

Abstract: a b s t r a c tToona sinensis (Juss.) M.Roem, Meliaceae, a deciduous plant native to eastern and southeastern Asia, is widely used in Traditional Chinese Medicine. This paper was aimed to summarize the current advances in traditional usage, phytochemistry, pharmacology and toxicology of T. sinensis. In this review, various types of data of T. sinensis are discussed in the corresponding parts of this paper, and perspectives for possible future studies of this plant are discussed. The main constituents of T. sin… Show more

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Cited by 70 publications
(54 citation statements)
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References 67 publications
(54 reference statements)
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“…It is well-known that natural products derived from plants are precious resource for finding candidate drugs for treating various inflammation-related diseases (Arulselvan et al 2016). In previous investigations, it was reported that T. sinensis contains various types of constituents, including terpenoids, phenylpropanoids, and flavonoids, and its main pharmacological activities of this plant are activities of anti-tumor, antioxidant, anti-diabetic, and anti-inflammatory (Peng et al 2019). Our present study found that azadirone (1) exhibited significant anti-inflammatory and analgesic properties, and the possible mechanisms are closely correlated to inhibition of proinflammatory cytokines and blocking MAPK signal pathway.…”
Section: Discussionmentioning
confidence: 99%
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“…It is well-known that natural products derived from plants are precious resource for finding candidate drugs for treating various inflammation-related diseases (Arulselvan et al 2016). In previous investigations, it was reported that T. sinensis contains various types of constituents, including terpenoids, phenylpropanoids, and flavonoids, and its main pharmacological activities of this plant are activities of anti-tumor, antioxidant, anti-diabetic, and anti-inflammatory (Peng et al 2019). Our present study found that azadirone (1) exhibited significant anti-inflammatory and analgesic properties, and the possible mechanisms are closely correlated to inhibition of proinflammatory cytokines and blocking MAPK signal pathway.…”
Section: Discussionmentioning
confidence: 99%
“…M. Roem., Meliaceae, is an important Chinese medicinal plant and has a long medicinal history for medicinal uses in Chinese folk medicine (Peng et al 2019). It has been reported that T. sinensis has the potential for reducing fever and swelling, stopping bleeding and diarrhea, relieving pain, and killing insects (Dong et al 2013).…”
Section: Introductionmentioning
confidence: 99%
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“…The highly durable timbers of T. sinensis are valuable raw materials for furniture manufacturing [3,4] . In addition, the bark and roots of T. sinensis are used in traditional medicines for the treatments of dysentery, enteritis, flatulence and itchiness [1,5] . In recent years, increasing numbers of studies report that T. sinensis is rich in bioactive compounds, such as phenolics, [6] polysaccharides, [7] and triterpenoids, [8] and exhibits various beneficial functions for human health, such as antioxidant, anticancer, anti‐angiogenesis, anti‐inflammatory, anti‐fatigue and anti‐nociceptive effects [5] .…”
Section: Introductionmentioning
confidence: 99%
“…Тритерпеноиды являются перспективными препаратами для лечения коронавирусных инфекций, так как способны не только препятствовать проникновению вируса в клетку, но и его размножению внутри клетки. Существует ряд обзоров [13][14][15][16][17][18][19][20][21], затрагивающих антикоронавирусные свойства тритерпеноидов. Однако имеющиеся работы в основном посвящены антиретровирусной и цитостатической активности тритерпеноидов.…”
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