Caryocar brasiliense induces vasorelaxation through endothelial Ca2+/calmodulin and PI3K/Akt/eNOS-dependent signaling pathways in rats

Oliveira, Lais Moraes de; Oliveira, Thiago Sardinha de; Costa, Rafael Menezes da; Martins, José Luís Rodrigues; Freitas, Carla; Gil, Eric de Souza; Costa, Élson Alves; Passaglia, Rita de Cássia Aleixo Tostes; Vaz, Boniek Gontijo; Filgueira, Fernando; Ghedini, Paulo César

doi:10.1016/j.bjp.2018.07.007

Cited by 7 publications

(10 citation statements)

References 28 publications

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“…However, CHE concentrations of 100 mg/kg and 300 mg/kg appear to be more effective in preventing neuronal death due to eosinophilic necrosis after 90 days of AlCl 3 intake. As plant crude extracts contain a myriad of components [26, 27], we hypothesize that compounds in CHE do not act independently, presenting either synergistic or antagonistic effects that may explain the absence of a correlation between CHE doses and morphological tests. Moreover, this same interpretation may explain the results, in which CHE exhibited better effects than quercetin.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant and Neuroprotective Properties ofEugenia dysentericaLeaves

Thomaz

Peixoto

Oliveira

et al. 2018

Oxidative Medicine and Cellular Longevity

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Eugenia dysenterica ex DC Mart. (Myrtaceae), popularly known as “cagaita,” is a Brazilian plant rich in polyphenols and other antioxidant compounds. Aiming to evaluate the potential use of cagaita in pathologies involving oxidative stress, such as neurodegenerative disorders, this study investigated its antioxidant potential and neuroprotective effect. Electrochemical approaches and aluminium-induced neurotoxicity were used to determine respectively in vitro and in vivo antioxidant properties of cagaita. Voltammetric experiments were carried out in a three-electrode system, whose working electrode consisted of glassy carbon. Male Swiss mice were administered with AlCl3 orally at a dose of 100 mg/kg/day and with cagaita leaf hydroalcoholic extract (CHE) at doses of 10, 100, and 300 mg/kg/day. The redox behavior of CHE presented similar features to that of quercetin, a widely known antioxidant standard. CHE prevented mouse memory impairment which resulted from aluminium intake. In addition, biochemical markers of oxidative stress (catalase, superoxide dismutase activity, and lipid peroxidation) were normalized by CHE treatment. The potential of CHE to prevent aluminium-induced neurotoxicity was reflected at the microscopic level, through the decrease of the number of eosinophilic necrosis phenotypes seen in treated groups. Moreover, the protective effect of CHE was similar to that of quercetin, which was taken as the standard. These findings showed that the CHE of cagaita leaves has a potential to protect the brain against oxidative-induced brain damage.

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Section: Resultsmentioning

confidence: 99%

Antioxidant and Neuroprotective Properties ofEugenia dysentericaLeaves

Thomaz

Peixoto

Oliveira

et al. 2018

Oxidative Medicine and Cellular Longevity

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“…Caryocaraceae is a small botanic family with exclusively neotropical distribution (Central and South America), but it is prevalent in the Amazon rainforest. The Caryocar genus has sixteen species, some of which have therapeutic [25,26] and economic potential [27], with fruits being a source of edible oil. Caryocar species, Caryocar brasiliense A.St.-Hil and Caryocar villosum (Aubl.)…”

Section: Native Plants Of the Amazonmentioning

confidence: 99%

Antioxidant, Hypoglycemic and Neuroprotective Activities of Extracts from Fruits Native to the Amazon Region: A Review

Yamaguchi

Souza

2020

BJI

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The Amazon forest has the largest biome on the planet, and it is estimated that only 16 to 20% of the identified animal, and plant biodiversity. Considering plant diversity, we will highlight the biological properties of the fruits extracts of Arecaceae, Caryocaraceae, Malvaceae, Myrtaceae, Sapindaceae, and Solanaceae’s families due to their significant biological actions. This review presents the antioxidant, glycemic control, and neuroprotective activities from ten fruit extracts distributed in six botanical families in the Amazon region. We obtained 801 publications (described from 2010 to 2020), of which 64 articles were selected by the benchmark previously chosen. The antioxidant effect was the dominant effect observed in the studies used for this review, followed by glycemic control and protective actions in neurons. This review provides a synopsis of the recent literature exploring the extracts from native fruits to the Amazon region that could efficiently prevent pathologies associated with oxidative stress, and cellular maintenance mechanisms.

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“…Literature reports that extracts from Cerrado plants promote vasorelaxation, as well as chemoinformatic studies indicate that secondary metabolites might interact with several receptors, henceforth leading to anti-inflammatory, anti-pyretic and anticancer activities [33][34][35][36]. Considering the complexity of the molecular basis of many neurodegenerative diseases, the potential of Cerrado plants to treat these as well as other disorders might be somewhat linked to such variety regarding biological activity, and the full scope of their therapeutic applicability is still being unravelled.…”

Section: Antioxidant and Anticholinesterase Properties Of Cerrado Floramentioning

confidence: 99%

Untitled

2020

AJBSR

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This short commentary is intended to briefly discuss the latest advances reported in literature about the use of native herbs from Brazilian Cerrado biome against neurodegenerative diseases. Henceforth, literature was surveyed concerning Cerrado`s rich biodiversity and the implications of the highly variable constitution of secondary metabolites of the plants of this region. Nonetheless, Cerrado herbs showcase remarkable antioxidant activity, as stated in literature, which is also associated to anticholinesterase properties, what implicates that some plants of this biome might find use in the therapeutics of neurodegenerative diseases.

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Caryocar brasiliense induces vasorelaxation through endothelial Ca2+/calmodulin and PI3K/Akt/eNOS-dependent signaling pathways in rats

Cited by 7 publications

References 28 publications

Antioxidant and Neuroprotective Properties ofEugenia dysentericaLeaves

Antioxidant and Neuroprotective Properties ofEugenia dysentericaLeaves

Antioxidant, Hypoglycemic and Neuroprotective Activities of Extracts from Fruits Native to the Amazon Region: A Review

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