1 H NMR-based nontargeted metabonomics study of plasma and urinary biochemical changes in Kudouzi treated rats

Chen, Jie; Zhang, Chenxu; Wu, Xiuli; Ji, Hongyan; Ma, Wei; Wei, Shijie; Zhang, Liming; Chen, Jing

doi:10.1016/j.bjp.2018.05.008

Cited by 3 publications

(2 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alanine is a non-essential amino acid that can be found abundantly in the muscles. It can generate pyruvate via reversible transamination and produce acetyl-CoA into the TCA cycle [ 64 ]. Decreased alanine level in the MFF group may be due to decreased level of leucine as BCAA is the main nitrogen source for alanine production in the muscles [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Serum Metabolomics Profiling of Commercially Mixed Functional Foods—Effects in Beta-Amyloid Induced Rats Measured Using 1H NMR Spectroscopy

et al. 2020

View full text Add to dashboard Cite

Functional foods such as pomegranate, dates and honey were shown by various previous studies to individually have a neuroprotective effect, especially in neurodegenerative disease such as Alzheimer’s disease (AD). In this novel and original study, an 1H NMR spectroscopy tool was used to identify the metabolic neuroprotective mechanism of commercially mixed functional foods (MFF) consisting of pomegranate, dates and honey, in rats injected with amyloid-beta 1-42 (Aβ-42). Forty-five male albino Wistar rats were randomly divided into five groups: NC (0.9% normal saline treatment + phosphate buffer solution (PBS) solution injection), Abeta (0.9% normal saline treatment + 0.2 µg/µL Aβ-42 injection), MFF (4 mL/kg MFF treatment + PBS solution injection), Abeta–MFF (4 mL/kg MFF treatment + 0.2 µg/µL Aβ-42 injection) and Abeta–NAC (150 mg/kg N-acetylcysteine + 0.2 µg/µL Aβ-42 injection). Based on the results, the MFF and NAC treatment improved the spatial memory and learning using Y-maze. In the metabolic analysis, a total of 12 metabolites were identified, for which levels changed significantly among the treatment groups. Systematic metabolic pathway analysis found that the MFF and NAC treatments provided a neuroprotective effect in Aβ-42 injected rats by improving the acid amino and energy metabolisms. Overall, this finding showed that MFF might serve as a potential neuroprotective functional food for the prevention of AD.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Ketone bodies can be converted into acetyl-CoA and enter TCA cycle. The generated energy will be distributed to the cells [ 46 , 64 , 73 , 75 ]. High 3-hydroxybutyrate level can also increase neuron survival in hypoxia, anoxia and ischemia conditions [ 76 ].…”

Section: Discussionmentioning

confidence: 99%

Serum Metabolomics Profiling of Commercially Mixed Functional Foods—Effects in Beta-Amyloid Induced Rats Measured Using 1H NMR Spectroscopy

et al. 2020

View full text Add to dashboard Cite

show abstract

A designed self-microemulsion delivery system for dihydromyricetin and its dietary intervention effect on high-fat-diet fed mice

et al. 2022

View full text Add to dashboard Cite

Current Trends in Toxicity Assessment of Herbal Medicines: A Narrative Review

et al. 2022

View full text Add to dashboard Cite

Even in modern times, the popularity level of medicinal plants and herbal medicines in therapy is still high. The World Health Organization estimates that 80% of the population in developing countries uses these types of remedies. Even though herbal medicine products are usually perceived as low risk, their potential health risks should be carefully assessed. Several factors can cause the toxicity of herbal medicine products: plant components or metabolites with a toxic potential, adulteration, environmental pollutants (heavy metals, pesticides), or contamination of microorganisms (toxigenic fungi). Their correct evaluation is essential for the patient’s safety. The toxicity assessment of herbal medicine combines in vitro and in vivo methods, but in the past decades, several new techniques emerged besides conventional methods. The use of omics has become a valuable research tool for prediction and toxicity evaluation, while DNA sequencing can be used successfully to detect contaminants and adulteration. The use of invertebrate models (Danio renio or Galleria mellonella) became popular due to the ethical issues associated with vertebrate models. The aim of the present article is to provide an overview of the current trends and methods used to investigate the toxic potential of herbal medicinal products and the challenges in this research field.

show abstract

1 H NMR-based nontargeted metabonomics study of plasma and urinary biochemical changes in Kudouzi treated rats

Cited by 3 publications

References 48 publications

Serum Metabolomics Profiling of Commercially Mixed Functional Foods—Effects in Beta-Amyloid Induced Rats Measured Using 1H NMR Spectroscopy

Serum Metabolomics Profiling of Commercially Mixed Functional Foods—Effects in Beta-Amyloid Induced Rats Measured Using 1H NMR Spectroscopy

A designed self-microemulsion delivery system for dihydromyricetin and its dietary intervention effect on high-fat-diet fed mice

Current Trends in Toxicity Assessment of Herbal Medicines: A Narrative Review

Contact Info

Product

Resources

About