Randomized controlled trial of Panax ginseng in patients with irritable bowel syndrome

Rocha, H. A. C.; Rocha, Thiago V.; Nóbrega, Fernando Jorge Firmino; Morais, Liana Clébia Soares Lima de; Diniz, Margareth F. F. Melo

doi:10.1016/j.bjp.2018.02.007

Cited by 3 publications

(1 citation statement)

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“…Furthermore, because the 5-HT3A receptor is closely related with IBS in enteric nervous system, oral administration of ginsenosides significantly and dose-dependently inhibited acetic acid-induced visceral hypersensitivity. A clinical study reported (Rocha et al, 2018) in Brazil also showed that the dry extract of ginseng could reduce abdominal pain in IBS patients. Clearly, from the above-mentioned pain causes ginseng and ginsenoside have a good therapeutic effect.…”

Section: Ginseng In Other Chronic Pain Conditionsmentioning

confidence: 92%

Progress on the Elucidation of the Antinociceptive Effect of Ginseng and Ginsenosides in Chronic Pain

Wei

2022

Front. Pharmacol.

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Ginseng (Panax ginseng C.A. Meyer) is a traditional Oriental herbal drug widely used in East Asia. Its main active ingredients are ginsenosides whose constituents are known to have various pharmacological activities such as anticancer, antinociception, and neuroprotection. The analgesic effects of ginsenosides, such as Rg1, Rg2, and Rb1, as well as compound K, are well known and the analgesic mechanism of action in inflammatory pain models is thought to be the down regulation of pro-inflammatory cytokine expression (TNF-α IL-1β, and IL-6). Several studies have also demonstrated that ginsenosides regulate neuropathic pain through the modulation of estrogen receptors. Recently, an increasing number of pathways have emerged in relation to the antinociceptive effect of ginseng and ginsenosides. Therefore, this review presents our current understanding of the effectiveness of ginseng in chronic pain and how its active constituents regulate nociceptive responses and their mechanisms of action.

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Section: Ginseng In Other Chronic Pain Conditionsmentioning

confidence: 92%