Zornioside, a dihydrochalcone C -glycoside, and other compounds from Zornia brasiliensis

Nascimento, Yuri Mangueira do; Abreu, Lucas Silva; Lima, Ramon; Silva, Anne Dayse S.; Costa, Vicente Carlos O.; Melo, José Iranildo Miranda de; Scotti, Marcus T.; Sobral, Marianna Vieira; Araújo, Silvany S; Filho, Manoel Adrião Gomes; Silva, Marcelo S.; Tavares, Josean Fechine

doi:10.1016/j.bjp.2018.02.003

Cited by 6 publications

(4 citation statements)

References 34 publications

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“…The extractive solution was collected every 72 hours, this collection, and the replacement of the solvent were repeated four times under the same powder. Then, the extractive solution was concentrated under reduced pressure in a rotary evaporator [ 5 ]. Flavonoids 7-methoxyflavone and 5,7-dimethoxyflavone were used as chemical markers for analysis and quantification, once they were isolated from ZB-EtOH AP [ 5 , 6 ].…”

Section: Methodsmentioning

confidence: 99%

“…According to phytochemical analysis of the ethanolic extract obtained from the aerial parts of Z. brasiliensis (henceforth ZB-EtOH AP ), several secondary metabolites have been isolated from this species, including saponins (soyasaponin IV and A 3 ) and terpenes (dihydromelilotosideo and roseosideo), among others. However, extracts obtained from Z. brasiliensis are mainly known for containing considerable amounts of flavonoids, such as 5hydroxy-7-methoxyflavone, 7,4-dimethoxy-isoflavone, 7methoxyflavone, and 5,7-dimethoxyflavone [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

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Antidiarrheal Effect of Zornia brasiliensis Vogel (Leguminosae) on Mice Involves Adrenergic Pathway Activation

Oliveira

Ferreira

Aires-Moreno

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Several secondary metabolites have been isolated from Zornia brasiliensis (Leguminosae), mainly flavonoids. These compounds are known for many pharmacological actions, such as antispasmodic and antidiarrheal. Therefore, we evaluated the antidiarrheal effect of the ethanolic extract obtained from Zornia brasiliensis aerial parts (ZB-EtOHAP), as well as its underlying mechanisms. Castor-oil-induced diarrhea, fluid accumulation, and intestinal transit (normal and castor oil induced) were performed to assess the antidiarrheal, antisecretory, and antipropulsive activities of the extract. The involvement of opioid and adrenergic pathways was also investigated. ZB-EtOHAP inhibited, in a dose-dependent manner, both total defecation frequency and the number of watery stools. The extract showed no effect on fluid accumulation or normal intestinal transit. On the other hand, when the animals were pretreated with castor oil, the extract decreased the distance traveled by the marker in the small intestine. Investigation of the involvement of opioid and adrenergic systems showed that the pharmacological potency of the extract did not change in the presence of naloxone, but it was reduced in the presence of yohimbine. The data indicate that Zornia brasiliensis has an antidiarrheal effect due to inhibition of the intestinal motility through adrenergic pathway activation.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antidiarrheal Effect of Zornia brasiliensis Vogel (Leguminosae) on Mice Involves Adrenergic Pathway Activation

Oliveira

Ferreira

Aires-Moreno

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…The dry and pulverized aerial parts of Z. brasiliensis (5 kg) were extracted with ethanol to obtain a crude ethanolic extract (CEE) which was partitioned with hexane, dichloromethane, ethyl acetate, ethyl acetate–methanol (90:10, v / v ) and ethyl acetate–methanol (50:50, v / v )in order to obtain its respective fractions [21].…”

Section: Methodsmentioning

confidence: 99%

“…Two pharmacological studies of this species have reported the antinociceptive activity of 7-methoxyflavone isolated from its aerial parts [19] and the antitumor activity of its essential oil [20]. A recent phytochemical study of the aerial parts of this species resulted in the identification of 14 compounds, including flavones, flavanones, isoflavonoids, pterocarpans, chalcones, and a novel glycosylated dihydrochalcone—and this chalcone showed cytotoxic activity against HL-60 leukemic cells [21].…”

Section: Introductionmentioning

confidence: 99%

Rapid Characterization of Triterpene Saponins from Zornia brasiliensis by HPLC-ESI-MS/MS

et al. 2019

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Zornia brasiliensis Vogel (Leguminosae) is a species popularly known in Brazil as “urinária”, “urinana”, and “carrapicho”, it is popularly used as a diuretic and in the treatment of venereal diseases. A specific methodology to obtain a saponin-enriched fraction and high-performance liquid chromatography coupled with diode array detection, ion trap mass spectrometry, and TOF-MS (HPLC-DAD-ESI-MS/MS) was applied for the analysis of triterpene saponins. The MS and MS/MS experiments were carried out by ionization in negative mode. Molecular mass and fragmentation data were used to support the structural characterization of the saponins. Based on retention times, high-resolution mass determination and fragmentation, 35 oleanane-triterpene saponins were tentatively identified in Z. brasiliensis.

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Flavonoids with chemotaxonomic significance from Cajanus scarabaeoides

Lan

Chiang

Lin

et al. 2020

Biochemical Systematics and Ecology

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Zornioside, a dihydrochalcone C -glycoside, and other compounds from Zornia brasiliensis

Cited by 6 publications

References 34 publications

Antidiarrheal Effect of Zornia brasiliensis Vogel (Leguminosae) on Mice Involves Adrenergic Pathway Activation

Antidiarrheal Effect of Zornia brasiliensis Vogel (Leguminosae) on Mice Involves Adrenergic Pathway Activation

Rapid Characterization of Triterpene Saponins from Zornia brasiliensis by HPLC-ESI-MS/MS

Flavonoids with chemotaxonomic significance from Cajanus scarabaeoides

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