Effects of hydroalcoholic extract of Celtis iguanaea on markers of cardiovascular diseases and glucose metabolism in cholesterol-fed rats

Zanchet, Barbara; Gomes, Denise B.; Silva, Vanessa da; Diel, Kriptsan Abdon Poletto; Schönell, Amanda P.; Faust, Caroline; Nicola, Patrícia Avello; Müller, Liz Girardi; Zanatta, Ana Paula; Wildner, Silvana M.; Bevilaqua, Fernanda; Chitolina, Rafael; Sachett, Adrieli; Zanatta, Leïla; Conterato, Greicy M. M.; Rocha, Cláudia Quintino da; Peretti, Camile; Brumelhaus, Tatiane; Alves, Nayara Souza; Menegatt, Jean Carlo Olivo; Conte, Fernanda; Serena, G.; Ramos, Adriano Tony; Zimermann, Francielli Cordeiro; Junior, Walter Antônio Roman

doi:10.1016/j.bjp.2017.12.001

Cited by 9 publications

(3 citation statements)

References 57 publications

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“…In previous studies, the ethanolic extract of C. australis and C. occidentalis leaves (El-Alfy et al 2011) and the hydromethanolic extract of C. australis leaves (Filali-Ansari et al 2015) significantly reduced in vitro MDA formation. The present findings were consistent with Zanchet et al (2018) who reported that a C. iguanaea supplement significantly decreased lipid peroxidation in cholesterol-fed rats by increasing SOD activity. Moreover, Arafa et al (2017) reported that in Cu-induced liver, the elevated hepatic ROS and suppressed total antioxidant capacity improved with quercetin treatment.…”

Section: Discussionsupporting

confidence: 93%

Protective effect of Celtis tournefortii against copper-induced toxicity in rat liver

et al. 2021

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This study aimed to investigate the antioxidant and hepatoprotective effects of Celtis tournefortii fruit extract (Ct) against copper-induced liver damage in rats. Thirty-two Wistar Albino rats were divided into four equal groups (n = 8): Control, Copper (Cu), Copper + C. tournefortii (Cu+Ct), and C. tournefortii (Ct). Superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) activities, glutathione (GSH) concentration, malondialdehyde (MDA), total antioxidant status (TAS) and total oxidant status (TOS) were analysed in the liver tissues. Liver histopathology was also evaluated. Alanine aminotransferase and lactate dehydrogenase significantly decreased in the Cu+Ct group compared with the Cu group. Oxidative stress parameters MDA and TOS significantly increased with copper administration, whereas they decreased with C. tournefortii co-treatment compared to Cu group. GSH concentration and TAS showed significant decreases with copper administration. Celtis tournefortii co-supplementation with copper significantly enhanced antioxidant parameters such as TAS, SOD, and GPx. Celtis tournefortii remarkably attenuated degenerative and necrotic changes caused by the oral exposure of copper in the liver tissue of rats. Celtis tournefortii may provide amelioration of the antioxidant status and moderation of severity of liver damage against copper toxicity. The therapeutic use of C. tournefortii may exhibit protective effects in liver injury treatment.

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Section: Discussionsupporting

confidence: 93%

Protective effect of Celtis tournefortii against copper-induced toxicity in rat liver

et al. 2021

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“…The chemical profile of MeOH extracts was obtained via LC‐MS and the molecule mass of compounds was registered as their respective ions [M‐H] ‐ . According to the molecule weight and previous research (Sommavilla et al., 2012; Zanchet et al., 2018), HPLC‐DAD analysis led to the isolation of approximately eight flavonoids compounds in MeOH extracts including some major peaks were identified as follows: (1) rutin; (2) orientin; (3) apigenin‐7‐O‐glucosylglucoside; (4) vitexin‐2''‐rhamnoside; (5) vitexin; (6) isovitexin; (7) kaempferitrin; (8) acacetin‐7‐O‐glucoside (Figure 4, Table 1).…”

Section: Resultsmentioning

confidence: 98%

Bioassay‐guided isolation of anti‐inflammatory constituents from Celtis sinensis leaves

Fang

Xie

et al. 2020

J. Food Biochem.

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Ginkgo acids (GAs) in ginkgo products usually lead to allergies or liver toxicity. In this study, the GA-induced toxicity was attenuated and Con A-induced T-lymphocyte proliferation was inhibited by extracts of Celtis sinensis leaves (ECSL). So, the active ingredients in ECSL were studied to solve the problems caused by GAs. First, the eight components of MeOH extracts were determined by HPLC-DAD/LC-MS. Then, the 12 active ingredients were separated based on the anti-inflammatory activity. Lymphocyte conversion showed that the inhibition rates of apigenin, quercetin, and isovitexin at 100 μM on Con A-activated proliferation of T cells were up to 82.46%, 62.86% and 42.76%, respectively. The inhibition rate on the LPS-induced NO release in RAW 264.7 cells of quercetin, apigenin, isovitexin, and vitexin were exceeding 80% at 100 μM. Taken together, the material foundation for the screen of GAs toxicityattenuated ingredients were provided here. Practical applications Ginkgo biloba extracts (EGBs) have been conducted to develop functional food which could increase blood circulation and enhance memory. Nevertheless, people in consumption of ginkgo products, often caused severe allergic reactions due to the potential allergens identified ginkgolic acids (GAs) of ginkgo products. We first find that the extracts of Celtis sinensis leaves can reduce GAs-induced damage on HepG2 liver cells. Then, the bioactive compounds in C. sinensis leaves were separated and purified based on anti-inflammatory activities against T cells. Quercetin, apigenin, and isovitexin showed well anti-inflammatory activities against Con A-activated T-lymphocytes and LPS activated RAW 264.7 macrophages. However, quercetin and apigenin are flavones O-glycosides which are rich in Ginkgo biloba. To solve the problems in Ginkgo biloba products caused by GAs, flavone C-glycoside (isovitexin) may be used for the further study in GAs toxicity-reduction.

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“…Gastro-protective effect of the hexane fraction from C. iguanaea was showed [13], and no cytotoxic or genotoxic effects were founded [14][15]. Recently, the hydroalcoholic extract was effective in treatment hyperglycemia, hypercholesterolemia and consequent prevention of atherosclerosis in rats [16]. Among the chemical components, coumarins, mucilage, and flavonoids have already been described in leaves and stems of C. iguanaea [11].…”

Section: Introductionmentioning

confidence: 99%

In vitro Antiproliferative Potential of Celtis iguanaea against Ovarian (OVCAR-3) and Colon (HT-29) Tumor Cell

Zanchet

Miorando

Gomes

et al. 2019

EJMP

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Natural products have been reported as a main source of anticancer molecules. The species Celtis iguanaea (Jacq.) Sarg., (Cannabaceae) is widely distributed in Brazil where it is known as “esporão-de-galo or taleira”. The leaves are popularly used as anti-inflammatory, in the treatment of body pain and urinary infections. However, the antiproliferative potential against human cancer cells remain to be elucidated. In this study, extracts and different fractions from the leaves of C. iguanaea were tested in vitro, against a panel tumor cell lines. The hydroalcoholic extract was inactive, while dichloromethane extract showed promisor antiproliferative effects. In turn, the dichloromethane fraction showed potent cytostatic activity against ovarian cell line (OVCAR-3, GI50 = 4.65 mg/ml). However, the stronger antiproliferative effects with high selectivity were observed for the hexane fraction that exhibited activity against ovarian (GI50 = 3.99 mg/ml) and colon (HT-29, GI50 = 3.16 mg/ml). The antiproliferative effects observed are probably related to the presence of 3,7,11,15-tetramethyl-2-hexadecen-1-ol and gamma-sitosterol present in the hexane fraction and detected by GC/MS. This is the first report of antiproliferative activity of C. iguanaea and the results suggested that the molecules of fraction hexane are promising chemotherapeutic compounds, especially against tumor cell of ovarian and colon.

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Effects of hydroalcoholic extract of Celtis iguanaea on markers of cardiovascular diseases and glucose metabolism in cholesterol-fed rats

Cited by 9 publications

References 57 publications

Protective effect of Celtis tournefortii against copper-induced toxicity in rat liver

Protective effect of Celtis tournefortii against copper-induced toxicity in rat liver

Bioassay‐guided isolation of anti‐inflammatory constituents from Celtis sinensis leaves

In vitro Antiproliferative Potential of Celtis iguanaea against Ovarian (OVCAR-3) and Colon (HT-29) Tumor Cell

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