Cytotoxic activity of abietane diterpenoids from roots of Salvia sahendica by HPLC-based activity profiling

Moradi-Afrapoli, Fahimeh; Shokrzadeh, Mohammad; Barzegar, Fatemeh; Gorji-Bahri, Gilar; Zadali, Reza; Ebrahimi, Samad Nejad

doi:10.1016/j.bjp.2017.11.007

Cited by 10 publications

(6 citation statements)

References 22 publications

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“…This data supported study results reported in the literature, which showed similar activity with extracts from Salvia sahendica; these extracts resulted in 100% inhibition at a concentration of 100 μg mL −1 for the same lineage and was categorized as a highly cytotoxic species. 42 Hexane extracts of S. tuberosa bark in human epidermoid cancer cells (HEp-2 cells) did not cause cytotoxicity at any concentration; conversely, an increase in cell number was observed at 250 μg mL −1 . 43 In this study, Spondias mombin extracts inhibited cell growth by 92.53% in HCT-116 cells, 98.41% in SNB19 cells, 99.23% in MCF-7 cells, and 90.48% in HL60 cells.…”

Section: Cytotoxicitymentioning

confidence: 90%

GC-MS-Based Metabolomic Profiles Combined with Chemometric Tools and Cytotoxic Activities of Non-Polar Leaf Extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam.

Guedes¹,

Filho²,

Silva³

et al. 2020

J. Braz. Chem. Soc.

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Agroindustrial residues, such as leaves of fruit plants, can be sources of bioactive molecules, thus adding value to co-products that are rarely explored in agroindustry. In this context, this study aimed to look into the phytochemical profiles in detail and to explore the antitumor potential of S. tuberosa and S. mombin leaves. We observed that, S. tuberosa leaf extract was cytotoxic in both tumor and healthy cells. S. mombin extracts selectively inhibited cell proliferation in the tumor cell line for prostate cancer (PC3) and did not significantly affect healthy cells. The metabolic profiles of the extracts were evaluated by gas chromatography coupled with mass spectrometry and twenty-three metabolites were identified. The correlation of metabolic profiles with cytotoxic tests indicated possible chemical markers that may be responsible for the inhibition of cell proliferation. This study revealed that the unexplored co-products in agroindustry may have great therapeutic potential, and therefore should be screened for biologically active compounds.

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Section: Cytotoxicitymentioning

confidence: 90%

GC-MS-Based Metabolomic Profiles Combined with Chemometric Tools and Cytotoxic Activities of Non-Polar Leaf Extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam.

Guedes¹,

Filho²,

Silva³

et al. 2020

J. Braz. Chem. Soc.

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“…The species were identified based on the taxonomic literature (Killip, 1938; E.C.S. Costa et al, 2015; Costa & Melo, 2016; Santos et al, 2016; Moradi‐Afrapoli et al, 2018) and geographical distributions of the species were verified using the following databases: speciesLink (https://specieslink.net/), Tropicos (http://www.tropicos.org/), and Flora do Brasil, 2021 (http://floradobrasil.jbrj.gov.br/).…”

Section: Methodsmentioning

confidence: 99%

Passifloroideae from coastal Piauí, Brazil

Silva¹,

Santos²,

Silva

et al. 2021

Feddes Repertorium

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In this floristic study, four species of Passiflora (Passiflora cincinnata, P. foetida, P. misera, P. subrotunda) were recorded in the coastal region of the Brazilian State of Piauí. The taxa occur in habitats with moist, muddy, sandy and stony substrates. The most prevalent species were P. foetida and P. subrotunda. An identification key is provided, together with descriptions of the species and data on their occurrence and distribution in the study region.

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“…Also, the water extract of S. amplexicaulis and S. ringens presented the strongest cytotoxic activity against K562 cells (Alimpic et al 2015). Moreover, Moradi-Afrapoli et al reported the abietane diterpenoids isolated from S. sahendica had cytotoxicity against cervical (HeLa) and colorectal adenocarcinoma (Caco-2) cancer cell with IC 50 5.4-41.4 lg/ mL (Moradi-Afrapoli et al 2018).…”

Section: Cytotoxic Activitymentioning

confidence: 99%

Antimicrobial and cytotoxic activity of extracts from Salvia tebesana Bunge and Salvia sclareopsis Bornm cultivated in Iran

Eghbaliferiz

Soheili

Tayarani‐Najaran

et al. 2019

Physiol Mol Biol Plants

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Salvia, a member of the Lamiaceae family, represents more than 58 species in Iran. In the present study, antibacterial and cytotoxic activity of extracts obtained from the roots of Salvia tebesana and Salvia sclareopsis were investigated. The antibacterial activity of the extracts was investigated against 4 bacterial strains and yeast using serial dilution method. The petroleum ether and CH 2 Cl 2 extracts of S. tebesana showed a good activity against Gram-positive bacteria particularly Bacillus cereus (MIC 1.25 mg/mL) while Gram-negative bacteria and yeast were resistant to the extracts. Also, the cytotoxic effects of the extracts on A2780 (ovarian), MCF-7 (breast) and DU 145 (prostate) cancer cell lines were examined using AlamarBlue Ò assay. The petroleum ether and CH 2-Cl 2 extracts of S. tebesana were found to be cytotoxic against the tested cell lines, with IC 50 values less than 50 lg/mL. The petroleum ether extract also showed a potent anti-proliferative activity against DU 145 cells with the lowest IC 50 value (6.25 lg/mL).

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Cytotoxic activity of abietane diterpenoids from roots of Salvia sahendica by HPLC-based activity profiling

Cited by 10 publications

References 22 publications

GC-MS-Based Metabolomic Profiles Combined with Chemometric Tools and Cytotoxic Activities of Non-Polar Leaf Extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam.

GC-MS-Based Metabolomic Profiles Combined with Chemometric Tools and Cytotoxic Activities of Non-Polar Leaf Extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam.

Passifloroideae from coastal Piauí, Brazil

Antimicrobial and cytotoxic activity of extracts from Salvia tebesana Bunge and Salvia sclareopsis Bornm cultivated in Iran

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