Hepatoprotective effect of Aegle marmelos augmented with piperine co-administration in paracetamol model

Rathee, Deepti; Kamboj, Anjoo; Sachdev, Rajneesh Kant; Sidhu, Shabir

doi:10.1016/j.bjp.2017.11.003

Cited by 13 publications

(3 citation statements)

References 37 publications

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“…Nos trabalhos citados, os grupos variaram de 5 animais (ALAM et al, 2017) até 23 por grupo (AHMAD et al,2019). Contudo, 60 trabalhos optaram por manter grupos com 6 animais (RATHEE et al, 2018). A definição do total de animais no experimento é extremamente importante, visando o uso consciente na experimentação animal e as diretrizes do Conselho Nacional de Controle de Experimentação Animal (Concea).…”

Section: Linhagem Idade Dos Animais E Gruposunclassified

Panorama atual do modelo de indução da hepatotoxicidade por paracetamol para estudos de hepatoproteção em ratos: Scoping review / Current overview of the model of induction of hepatotoxicity by paracetamol for studies of hepatoprotection in rats: Scoping review

Almeida¹,

Câmara²,

Barcelos³

et al. 2022

BJDV

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RESUMOOs medicamentos são considerados xenobióticos pelo organismo humano, isto é, moléculas estranhas. O fígado é o grande responsável pelo processo de metabolização, onde os compostos lipossolúveis são transformados em moléculas com características hidrossolúveis, por meio de reações químicas, com a finalidade de facilitar a excreção renal, principalmente. O paracetamol é um anti-inflamatório da classe não esteroidal (AINES), utilizado para tratamento de dor e febre e pode ser adquirido sem nenhuma prescrição médica, portanto e extremamente utilizado pela população. Mesmo sendo um medicamento de venda livre, este fármaco apresenta um potencial hepatotóxico, dependente de dose, podendo gerar lesão em hepatócitos. Assim, o modelo de lesão hepática induzida por paracetamol é um dos modelos mais populares para testar potenciais agentes hepatoprotetores. No entanto, existem muitas variações neste modelo e a falta de padronização impacta diretamente no tempo de experimento, quantidade de animais utilizados e elevados custos com insumos e fármacos. A presente revisão teve

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Section: Linhagem Idade Dos Animais E Gruposunclassified

Panorama atual do modelo de indução da hepatotoxicidade por paracetamol para estudos de hepatoproteção em ratos: Scoping review / Current overview of the model of induction of hepatotoxicity by paracetamol for studies of hepatoprotection in rats: Scoping review

Almeida¹,

Câmara²,

Barcelos³

et al. 2022

BJDV

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“…The leaf extract of Aegle marmelos at a dose of 100mg/kg was found to exhibit potent hepatoprotective activity in PCM-induced hepatotoxicity in Wistar rats, comparable to the silymarin group. When Piperine was co-administered with a low dose of 25mg/kg of Aegle marmelos extract, the hepato-protective effect was found to have got potentiated 25 .…”

Section: Hepatoprotective Activitymentioning

confidence: 99%

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2022

IJPSR

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Aegle marmelos, commonly known as Bael or Bilva, is a traditional tree belonging to the family Rutaceae with enormous value in ethnobotany, Ayurveda, and has been used since time immemorial for its spiritual significance as an offering to Lord Shiva while worshipping. Looking at its religious perspective and medicinal benefits, people have conserved trees of Bael in sacred groves. It is a sub-tropical tree and grows wildly in the dry, dry dipterocarp and mixed deciduous forests on the plains and hilly regions. Researchers have used and studied almost all the parts like root, bark, fruit, leaves, and seeds of this significant tree because of the varied phytoconstituents isolated from them, like alkaloids and terpenoids, amino acids, fatty acids, coumarins, etc. Substantial experiments were conducted on Aegle marmelos owing to many phytoconstituents found in it and they were found to exhibit potential therapeutic responses in many pharmacological activities like anti-diabetic, anti-hyperlipidemic, analgesic, antimicrobial, antipyretic, anti-inflammatory, radioprotective, anti-ulcer, anticancer, gastroprotective, antidiarrheal, etc., to name a few. Many pharmaceutical herbal industries have been formulating preparations using different parts of Aegle marmelos for quite a long. Still, there are yet many segments that have been overlooked, leaving big grounds for cutting-edge work. Hence, it was worthy of putting forward a consolidated and updated overview of the pharmacognostic aspect of Aegle marmelos, incorporating its phytoconstituents, therapeutic properties, and ethnomedicinal benefits for aiding the scientists, students, and aspiring researchers for futuristic research on this significant plant, for promoting its rigorous large scale cultivation and ethno conservation and also for manifesting the potential of this plant in the pharmaceutical industry for herbal formulations.

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“…It has enormous economic and ecological value. It was found that various pharmacological activities were exhibited by different parts of this tree, like, anti-cancer 12 , analgesic 13 , antipyretic 14 , anti-inflammatory 15 , anti-malarial 16 , antioxidative 17 , hepatoprotective 18 , antidiabetic 19 , antimicrobial 12 , antiulcer 20 , gastroprotective 21 , antidiarrheal 22 , cardioprotective 23 , radioprotective 24 , anti-spermatogenic 25 , antiproliferative 26 , anti-hyperlipidemic 27 , immunomodulatory 28 , anti-thyroid 29 etc. Several phytochemicals were segregated from different parts of Aegle marmelos, like glycosides, terpenoids, alkaloids, coumarins, carbohydrates, saponins, phenols, sterols, gums and mucilage, tannins etc., which were thought to have attributed to their pharmacological responses.…”

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confidence: 99%

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2023

IJPSR

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Aegle marmelos, commonly known as Bael or Bilva, belonging to family Rutaceae, has been a tree of humongous significance since time immemorial. It has been used tremendously in ethnomedicine and ethnobotany owing to its spiritual connection. There are testimonials of its prolific use in Ayurveda, Unani and Siddha system of medicine. People also have found this tree of utility owing to its ecological and economic perspective. Almost all the parts of this tree are beneficial and have been used for various reasons. This research was undertaken to ascertain anti-anxiety and antidepressant responses in the hydroalcoholic leaf extract of Aegle marmelos employing the Elevated plus Maze for anxiety and Tail Suspension Test model for depression. Phytochemical screening of the prepared extract was also performed to recognize the phytochemicals possibly accountable for the selective psychotropic activities in the plant. A hydroalcoholic leaf extract using 50% ethanol was prepared and screened for presence of different phytochemicals and was found to comprise alkaloids, carbohydrates, flavonoids, tannins, saponins, terpenoids, coumarins, phenols, and reducing sugars. The findings revealed that AME 200 mg/kg and 400 mg/kg ameliorated the anxiolytic response by increasing the total time spent and number of entries made in the open arms in the elevated plus maze compared to the control. Also, the AME at 400 mg/kg dose, showed a dosedependent, comparable response to the standard drug diazepam 2 mg/kg. Also, when AME was administered at 200 mg/kg and 400 mg/kg orally in the mice in the TST, it caused marked reduction in the total time of immobility in mice compared to the control. Also, the AME 400 mg/kg dose showed a dose-dependent and comparable response to the standard drug Fluoxetine 20 mg/kg. Thus, Aegle marmelos hydroalcoholic leaf extract is inferred to possess anxiolytic and antidepressant therapeutic responses and can serve as a potential agent against the available synthetic marketed preparations. INTRODUCTION:With the advancement of technology and hastily changing lifestyle, there is an unceasing entail to corroborate own abilities in work and society and people are inadvertently making them fall in the grip of psychotropic diseases.

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Hepatoprotective effect of Aegle marmelos augmented with piperine co-administration in paracetamol model

Cited by 13 publications

References 37 publications

Panorama atual do modelo de indução da hepatotoxicidade por paracetamol para estudos de hepatoproteção em ratos: Scoping review / Current overview of the model of induction of hepatotoxicity by paracetamol for studies of hepatoprotection in rats: Scoping review

Panorama atual do modelo de indução da hepatotoxicidade por paracetamol para estudos de hepatoproteção em ratos: Scoping review / Current overview of the model of induction of hepatotoxicity by paracetamol for studies of hepatoprotection in rats: Scoping review

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