Phytochemical composition and chronic hypoglycemic effect of Rhizophora mangle cortex on STZ-NA-induced diabetic rats

Andrade‐Cetto, Adolfo; Escandón-Rivera, Sonia; Torres-Valle, Gerado Mata; Quijano, Leovigildo

doi:10.1016/j.bjp.2017.09.007

Cited by 18 publications

(17 citation statements)

References 16 publications

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“…For the past few years, numerous extracts have been isolated from plant and used as a promising source of therapeutic agents for diabetes mellitus such as Coptis chinensis (Jiang et al, 2013), Rhizophora mangle cortex (Andrade-Cetto et al, 2017), Lilium lancifolium (Zhang et al, 2014), pumpkin (Wang et al, 2017a), peach gumderived polysaccharide (Wang et al, 2017b), Momordica charantia , Talinum triangulare , Ocimum gratissimum (Livia et al, 2014), Citrus macroptera Montr (Uddin et al, 2014), Eugenia jambolana (Kishalay et al, 2015), Prunus cerasus L. (Fatima et al, 2017), Gaultheria trichophylla (Fiaz et al, 2017), Rhizo-phora mangle (Adolfo et al, 2017) and so on.…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic potential of Elaeagnus angustifolia fruit polysaccharide on streptozotocin-induced type 2 diabetic mice

Wang

Hong

Cui

et al. 2018

Bangladesh J Pharmacol

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In this study, the hyperglycemic potential of Elaeagnus angustifolia fruit polysaccharide in both normal healthy and streptozotocin-induced diabetic mice was investigated. Results showed no significant effect of E. angustifolia fruit polysaccharide on blood glucose level in normal control group, while E. angustifolia significantly suppressed the rise in blood glucose of diabetic mice. In addition, in the first two weeks of administration, the body weight was decreased both in negative control group and E. angustifolia groups, however, E. angustifolia (800 mg/kg) was recovered to the began weight in the fourth week. E. angustifolia (800 mg/kg) could markedly reduce the levels of total cholesterol, triglyceride and improve the level of high density lipoprotein-cholesterol. The results suggest that E. angustifolia could be considered as an ingredient of functional foods for diabetes.Video Clip of Methodology:10 min 19 sec <a href="https://www.youtube.com/v/a3ikXeeByP8">Full Screen</a> <a href="https://www.youtube.com/watch?v=a3ikXeeByP8">Alternate</a>

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Section: Introductionmentioning

confidence: 99%

Hypoglycemic potential of Elaeagnus angustifolia fruit polysaccharide on streptozotocin-induced type 2 diabetic mice

Wang

Hong

Cui

et al. 2018

Bangladesh J Pharmacol

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“…Different extracts were prepared to study the plants' hypoglycemic effect. A water extract similar to the traditionally used tea (W) was prepared by boiling 20 g of dry plant material with 500 ml of water, followed by filtration and lyophilization, as previously described [18, 19]. An ethanol-water extract (EW) was prepared by adding 20 g of the plant material to 500 ml of an ethanol and water mixture (50:50); then, the mixture was heated at 40°C for four hours and filtered three times, followed by evaporation in a Buchi rotary evaporator.…”

Section: Methodsmentioning

confidence: 99%

Hypoglycemic Activity of Medicinal Plants Used among the Cakchiquels in Guatemala for the Treatment of Type 2 Diabetes

Andrade‐Cetto

Cruz

Cabello-Hernández

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Type 2 diabetes (T2D) is a major health problem worldwide. In this condition, the organism can produce insulin but becomes resistant to it; thus the insulin is ineffective. High blood glucose levels are a result of insulin resistance and insulin deficiency; they produce diabetes-associated complications such as kidney failure, blindness, cardiovascular disease, and lower-limb amputation. In Guatemala, there were over 752.700 cases of the disease in 2017 with prevalence of 8.4 (IDF, 2017). The use of plants for medicinal purposes has been practiced in the country since pre-Hispanic times. Among the Cakchiquels, the aerial parts of Hamelia patens Jacq., Neurolaena lobata (L.) R.Br. ex Cass., and Solanum americanum Mill. and the cortex of Croton guatemalensis Lotsy are used to treat type 2 diabetes. The aim of the present study was to confirm the hypoglycemic effect of the plants under normal conditions and under maltose and sucrose tolerance tests, as well as to test the activity of the plant extracts in vitro against alpha-glucosidases types I and II. In agreement with the traditional usage of the plants, in normal conditions without a sugar load, the extracts produced a statistically significant hypoglycemic effect similar to the control drug glibenclamide. When the sugar load was maltose, only Croton and Solanum produced a statistically significant (p < 0.05) hypoglycemic effect compared to the control drug, but when the sugar was sucrose, Croton and Hamelia produced a statistically significant effect (p < 0.05) beginning at 30 min compared to the control group, while Solanum did so at 60 min and Neurolaena at 90 min. In vitro assays showed that the extracts inhibited yeast alpha-glucosidases but not the rat intestinal ones. Of the tested plants, Croton exert an effect both under sugars' tests and under a normal tolerance test; these results suggest the potential use of this plant. The results presented here provided evidence based on the use of these plants as hypoglycemic agents in the treatment of type 2 diabetes.

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“…Table 1. Compounds detected in the Anomalocalyx uleanus methanolic extracts by UPLC-Q-TOF-MS/MS (compounds 1-46) and gas chromatography-mass spectrometry (GC-MS) (47)(48)(49)(50). Level of confirmation: Level 1 (L1): structure confirmed by reference standard or structure elucidation by NMR spectroscopy, level 2a (L2a): probable structure by library spectrum match, and level 3 (L3): tentative candidates based on MS and MS 2 experimental data [18,19].…”

Section: Isolation Of Majoritary Compound From a Uleanus Leavesmentioning

confidence: 99%

“…The hexane partition of the leaf extract was fractionated with silica gel (adsorption chromatography), and the 9D subfraction was derivatized for analysis using GC-MS. The GC-MS data were compared with the NIST library, making it possible to identify four fatty acid esters: palmitic acid (methyl ester) (47), linoleic acid (methyl ester) (48), stearic acid (methyl ester) (49), and oleic acid (methyl ester) (50).…”

Section: Dereplicated Compounds From a Uleanus Of Methanolic Roots mentioning

confidence: 99%

Chemophenetic Significance of Anomalocalyx uleanus Metabolites Are Revealed by Dereplication Using Molecular Networking Tools

et al. 2021

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Anomalocalyx uleanus (Pax & K. Hoffm.) Ducke (Euphorbiaceae) is a singular species in the genus and is restricted and exclusive to the Brazilian Amazon. A phytochemical study of A. uleanus leaves was performed, yielding the isolation of five major compounds: catechin/epicatechin, afzelin, quercetin 3-O-α-L-rhamnopyranoside, and astilbin. The phytochemical compositions of the methanolic extracts of leaves, roots, bark, and stem bark were determined using a dereplication approach. Forty-six compounds were annotated from the liquid chromatography-mass spectrometry (LC-MS/MS) data, while four lipids were identified using gas chromatography-mass spectrometry (GC-MS). In total, fifty compounds were detected, and they belonged to the primary metabolism and several classes of natural products such as flavonoids, flavonoids O-glycosides, flavonoids C-glycosides, biflavonoids, procyanidin, triterpene, triterpenes esterified with phenylpropanoids, phenylpropanoid derivatives, flavonolignans, coumarins, quinic acid derivatives, and benzoic acid derivatives. This is the first report on the phytochemical data of the genus Anomalocalyx, and the results of this study will contribute to the chemosystematic knowledge of the Euphorbiaceae family and justify the need for investigation of the pharmacological potential of the species A. uleanus.

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Phytochemical composition and chronic hypoglycemic effect of Rhizophora mangle cortex on STZ-NA-induced diabetic rats

Cited by 18 publications

References 16 publications

Hypoglycemic potential of Elaeagnus angustifolia fruit polysaccharide on streptozotocin-induced type 2 diabetic mice

Hypoglycemic potential of Elaeagnus angustifolia fruit polysaccharide on streptozotocin-induced type 2 diabetic mice

Hypoglycemic Activity of Medicinal Plants Used among the Cakchiquels in Guatemala for the Treatment of Type 2 Diabetes

Chemophenetic Significance of Anomalocalyx uleanus Metabolites Are Revealed by Dereplication Using Molecular Networking Tools

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