Anti-caries activity of selected Sudanese medicinal plants with emphasis on Terminalia laxiflora

Mohieldin, Ebtihal Abdalla M.; Muddathir, Ali Mahmoud; Yamauchi, Kosei; Mitsunaga, Tohru

doi:10.1016/j.bjp.2017.04.002

Cited by 9 publications

(4 citation statements)

References 41 publications

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“…Two singlet signals at δ H 7.15 and 7.45 were evident in the 1 H NMR spectrum ( Figure S6A ). The 13 C-NMR signals were in agreement with literature data [ 37 , 38 ] and, in particular, signals at δ C 160.3 and 158.8 ( Figure S6C ) indicated two lactonised carbonyl carbons. Methyl-flavogallonate ( 6 ) was isolated as a yellow amorphous powder.…”

Section: Resultssupporting

confidence: 89%

Unravelling the Antibacterial Activity of Terminalia sericea Root Bark through a Metabolomic Approach

et al. 2020

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Terminalia sericea Burch. ex. DC. (Combretaceae) is a popular remedy for the treatment of infectious diseases. It is widely prescribed by traditional healers and sold at informal markets and may be a good candidate for commercialisation. For this to be realised, a thorough phytochemical and bioactivity profile is required to identify constituents that may be associated with the antibacterial activity and hence the quality of raw materials and consumer products. The aim of this study was to explore the phytochemistry and identify the antibacterial constituents of T. sericea root bark, using a metabolomic approach. The chemical profiles and antibacterial activities of 42 root bark samples collected from three districts in the Limpopo Province, South Africa, were evaluated. Dichloromethane:methanol (1:1) extracts were analysed using ultraperformance liquid chromatography (UPLC)-mass spectrometry (MS), and chemometric models were constructed from the aligned data. The extracts were tested against Bacillus cereus (ATCC 11778), Staphylococcus epidermidis (ATCC 12223), Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 8739), Klebsiella pneumoniae (ATCC 13883), Pseudomonas aeruginosa (ATCC 27853), Shigella sonnei (ATCC 9292) and Salmonella typhimurium (ATCC 14028), using the minimum inhibition microdilution assay. Nine compounds; sericic acid, sericoside, resveratrol-3-O-β-rutinoside, ellagic acid, flavogallonic acid dilactone, methyl-flavogallonate, quercetin-3-(2′′-galloylrhamnoside), resveratrol-3-(6′′-galloyl)-O-β-d-glucopyranoside and arjunetin, were isolated from the root bark. All the compounds, with the exception of sericic acid, sericoside and resveratrol-3-O-β-rutinoside, were isolated for the first time from the root bark of T. sericea. Chemometric analysis revealed clustering that was not population specific, and the presence of three groupings within the samples, characterised by sericic acid, sericoside and an unidentified compound (m/z 682/4.66 min), respectively. The crude extracts from different populations displayed varied antibacterial activities against S. typhimurium (minimum inhibitory concentrations (MICs) 0.25–1.0 mg/mL), but similar activity towards Bacillus cereus (1.0 mg/mL). Several compounds present in the root bark were highly active towards all or most of the pathogens tested, but this activity was not reflected by the chemical profiles of extracts prepared from the individual samples. Among the pure compounds tested, only flavogallonic acid dilactone and methyl-flavogallonate exhibited broad-spectrum activity. A biochemometric analysis indicated that there was no consistent association between the levels of phytochemicals and the activity of the active or non-active extracts. Although it was deduced that the major constituents of T. sericea root bark contributed to the chemotypic variation, further investigation of the interactions of compounds present in the root bark may provide antibacterial efficacies not evident when examining compounds singularly. The data reported herein will provide information that is fundamentally important for the development of quality control protocols.

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Section: Resultssupporting

confidence: 89%

Unravelling the Antibacterial Activity of Terminalia sericea Root Bark through a Metabolomic Approach

et al. 2020

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“…The last was also the major constituent of essential oil from Guarea kunthiana, a fact that may explain the moderate antibacterial activity shown by the oils under study (Pandini et al, 2018). In short, plants keep being promising targets of studies in the search for compounds that have anti-decay activity so as to enable the production of new agents for oral hygiene (Mohieldin et al, 2017).…”

Section: Resultsmentioning

confidence: 98%

Chemical composition and in vitro antibacterial activity of essential oils from Murraya paniculata (L.) Jack (Rutaceae) ripe and unripe fruits against bacterial genera Mycobacterium and Streptococcus

Silva

Fernandes

Santiago

et al. 2020

Braz. J. Pharm. Sci.

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This study aims to investigate chemical composition of essential oils from Murraya paniculata (L.) Jack (Rutaceae) ripe and unripe fruits and determine their in vitro antibacterial activity. Essential oils were extracted by hydrodistillation from Murraya paniculata (L.) Jack ripe and unripe fruits collected in the Cerrado, in Rio Verde, southwestern Goiás, Brazil. They were analyzed by gas chromatography with flame ionization detector (GC-FID) and by gas chromatography-mass spectrometry (GC-MS). Sesquiterpenes, which represent the most abundant class of compounds in oils, predominated in both ripe and unripe fruits. Major constituents of essential oils extracted from ripe fruits (RF-EO) were β-caryophyllene (21.3%), α-ylangene (13.3%), germacrene-D (10.9%) and α-zingiberene (9.7%) whereas the ones of unripe fruits (UF-EO) were sesquithujene (25.0%), α-zingiberene (18.2%), germacrene-D (13.1%) and α-copaene (12.7%). In vitro antibacterial activity of essential oils was evaluated in terms of its minimum inhibitory concentration (MIC) values by the broth microdilution method in 96-well microplates. Both essential oils under investigation showed moderate anti-streptococcal activity against the following bacteria: Streptococcus mutans, S. mitis, S. sanguinis, S. sobrinus and S. salivarius. MIC values ranged between 100 and 400 µg/mL. Regarding the antimycobacterial activity, essential oils from M. paniculata (L.) Jack unripe and ripe fruits were active against Mycobacterium kansasii (MIC = 250 µg/mL), moderately active against M. tuberculosis (MIC = 500 µg/mL) and inactive against M. avium (MIC = 2000 µg/mL). This study was pioneer in revealing similar chemical profiles of both essential oils extracted from Murraya paniculata (L.) Jack unripe and ripe fruits, besides describing their in vitro anti-streptococcal and antimycobacterial activities.

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“…Some tree species were recorded as highest potent antibacterial activities (inhibition zone 30 mm or more), namely: Acacia nioltica (Grad, Sunt), Adansonia digitata (Tabaldi), Ziziphus spina-christi (Seder, Nabag), Eucalyptus globules (Ban), Kigelia Africana (Umshotoor) and Dichrostachys cinerea (Kadad) 3,22 . Terminalia laxiflora (Daroat) stem and stem bark are used as antiseptics for mouthwash to prevent gingivitis and thrush 3,23 . Hyphaene thebaica (doum), Palmae, contain saponins, tannins, catechins, flavonoids, terpenoids and ketones 22,24 .…”

Section: Some Sudanese Trees As Source Of Traditional Medicinesmentioning

confidence: 99%

“…The most important medicinal plants in Sudan from economic point of view and have contribution to Sudanese national income according to Bank of Sudan (2007-2017) were (Table 1) Acacia nilotica (Sunt) 3 , Acacia Senegal (Hashab) 7 , Acacia seyal (Talih) 3 , Adansonia digitate (Tabaldi) 3 , Aloe sankitana (Sabar) 1 , Aristolochia bracteolate (Um galgil) 23 , Azadirachta indica (Neem) 43 , Balanites aegyptiaca (Heglig) 44 , Boswellia papyrifera (Tarag tarag) 3 , Carcica papaya (Papya) 45 , Cassia acutifolia (Senna) 47 , Citrullus colocynthis (Handal) 48 , Cuminum cyminum (kammun) 46 , Cymbopogen proximus (al-Yaman Maharaib) 49 , Haplophyllum tuberculatum (komesht ennebi) 50 , Hibiscus sabdariffa (Karkade) 36 , Hyphaene thebaica (Doum) 22 , Grewia tenax (Gudaim) 3 , Lawsonia inermis (henna) 1 , Nigella sativa (Al Haba Alsoda black cumin) 25 , Ocimum basilicum (al-raihan) 51 , Ocimum santicum (Habaq) 52 , Phoenix dactylifera (Nahkeel, Date palm) 53 , Ricinus communis (Kharwee) 55 , Salvadora persica (Arāk, miswaak ) 54 , Sesamum indicum (Simsim) 38 , Solenostemma argel (Hergel) 22 , Tamarindus indica (Aradeeb) 56 , Terminalia brownii (Arza, Sobag) 20 23 Koul et al 43 Chothani 53 Marwat et al 55 Kumar et al 54 Abushama Elnour. et al 19 Zohrameena et al 56 Abdalla, et al 20 Issa et al …”

Section: Economical Medicinal Plants From Sudanmentioning

confidence: 99%

A Look at Some Medicinal Plants from Sudan-Mini Review

Khider¹

2018

Journal of Advanced Pharmacy Research

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Sudan has large area, with multi-culture, habits rich biodiversity and medicinal plants, although was divided in 2011 into two countries still rich with valuable medicinal plants. The objective of the present mini review is to indicate and document some medicinal plants from Sudan and reflect their valuable uses in treating some indigenous and tropical diseases. The present mini-review gave a look at some of these plants, mentioning their families, distribution, their local names, their habits, the plant part used for treating diseases and mode of treatment. The medicinal and Aromatic Plants Research Institute (MAPRI) of the National Centre for Research (NCR) plays major role in medicinal and aromatic plants investigation, determination, valuation and documentation in Sudan and contributes with local healers in different regions of Sudan, the rediscovering of these plants is highly needed with contribution of overseas pharmaceuticals companies as natural products have less side effects than industrial drugs.

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Anti-caries activity of selected Sudanese medicinal plants with emphasis on Terminalia laxiflora

Cited by 9 publications

References 41 publications

Unravelling the Antibacterial Activity of Terminalia sericea Root Bark through a Metabolomic Approach

Unravelling the Antibacterial Activity of Terminalia sericea Root Bark through a Metabolomic Approach

Chemical composition and in vitro antibacterial activity of essential oils from Murraya paniculata (L.) Jack (Rutaceae) ripe and unripe fruits against bacterial genera Mycobacterium and Streptococcus

A Look at Some Medicinal Plants from Sudan-Mini Review

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