Anti-inflammatory activity and chemical composition of dichloromethane extract from Piper nigrum and P. longum on permanent focal cerebral ischemia injury in rats

Pulverizing processes affect the chemical quality and thermal property of black, white, and green pepper (Piper nigrum L.)

“…Black, white, and green peppers are derived from the fruits of Piper nigrum L., which belongs to the Piperaceae family. The main constituents of pepper are volatile oils and piperine, which contribute to the antioxidant, antimutagenic, antitumor, antibacterial, antifungal, analgesic, and anti-inflammatory activities, and offers immense pharmacological benefits (Butt et al 2013;Zarai et al 2013;Tasleem et al 2014;Nikolić et al 2015;Zou et al 2015;Luz et al 2016;Tang et al 2017;Chandran et al 2017;Wang et al 2017). The effective substances and most chemical components of pepper are heatsensitive substances.…”

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“…methyl piperine, iperonaline, piperettine, asarinine, piperundecalidine, piperlonguminine, pregumidiene, brachystamide, brachystamide-A, brachystine, pipercide, longamide, tetrahydropiperine, dehydro-pipernonaline, piperidine, terahydropiperlongumine and trimethoxycinnamoyl-piperidinone has been found in the root of long pepper. The essential oil of the fruit contains caryophyllene, pentadecane, bisabolene, thujone, terpinolene, zingiberine, p-cymene, pmethoxyacetophenone and dihydro-carveol apart from piperine [94][95][96][97][98] . Maximum ACE inhibitory activity has been recorded by ethyl acetate and butanol fractions of black pepper with halfmaximal inhibitory concentration (IC 50 ) value of 1.40 ± 0.07 mg/ml and 1.75 ± 0.43 mg/ml, respectively 99 .…”

Scientific Review of Tribhuvan Keerti Ras a potent Ayurvedic Herbomineral Combination against viral infection.

“…Marich: Pharmacological activity of Piper nigrum: Effect in pharmacokinetic of drugs [39] . Effect in Bioavailability [40] , Toxicity activity [41] , Effects in stomach [42] , Effect in bile secretion [43] Anti-diarrheal [44] , Antimicrobial [45] , Anti-inflammatory [46] , Anti-obesity [47] , Antidiabetic [48] Anticancer [49] and tumor reduction activity [50] , Antihypertensive [51] , Antiasthmatic, Anti-adipogenesis activity [52] , Effects in metabolism [53] , Effects in neurodegeneration and cognitive impairment [54] , 6) Shunthi :…”