Rats treated with Hypericum perforatum during pregnancy generate offspring with behavioral changes in adulthood

Campos, Leandro V.; Vieira, Vinícius; Silva, Lorena R.; Jasmin, Jasmin; Guerra, Martha O.; Peters, Vera Maria; Sá, Rita de Cássia da Silveira e

doi:10.1016/j.bjp.2017.01.004

Cited by 3 publications

(6 citation statements)

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“…The same research group used fluorescence imaging to measure hypericin levels in maternal and fetal tissue samples, the behaviour of exposed dams post‐parturition and male offspring using models that assess anxiety and depression (Campos, Guerra, Peters, & E Sá, ; V. A. Vieira, Campos, et al, ). In another study, Campos, Vieira, et al (), while not specifically assessing toxicity, explored the effects of perinatal exposure and the potential for central nervous system (CNS) changes in female offspring.…”

Section: Resultsmentioning

confidence: 99%

“…Campos, Viera, et al () and M. L. Vieira, Hamada, et al, () quote Cupri referring to it as a study assessing the effects of St John's wort on rats, when the study was carried out on mice (Crupi et al, ).…”

Section: Resultsmentioning

confidence: 99%

“…To aid comparison, the daily dose of SJW extract has been converted into a daily human dose based on milligrams per kilogram of body weight. Studies authored by V. A. Vieira, Campos, et al () and Campos, Vieira, et al () report the work of the same study group and investigate the effect of SJW on the dams post‐parturition and on their male offspring. Wistar rats exposed to a dose of SJW extract equivalent to a 60‐kg human dose of 8.64 g/day, during pregnancy or in utero, recorded results indicative of reduced anxiety and reduced depression in these tests, compared with the control group, with dams exposed to the second highest dose (4.32 g/day) also showing significant reductions in some parameters.…”

Section: Resultsmentioning

confidence: 99%

“…Two groups of Sprague‐Dawley rats, used in Cada et al (), were exposed to doses comparable with and much higher than those used by the Vieira/Campos team. Campos identifies different methods of administering of the SJW; Cada et al () mixed the SJW in the animal chow, whereas Campos, Vieira, et al () used gavage. This is just one of a number of variables that may account for the variability in outcome, and we reiterate that importantly independent identification of the characteristics of the SJW extract was not carried out making the dose estimates unreliable.…”

Section: Resultsmentioning

confidence: 99%

“…In another study, Campos, Vieira, et al (2017), while not specifically assessing toxicity, explored the effects of perinatal exposure and the potential for central nervous system (CNS) changes in female offspring.…”

Section: Resultsmentioning

confidence: 99%

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The safety of St John's wort (Hypericum perforatum) in pregnancy and lactation: A systematic review of rodent studies

Avila

Whitten

Evans

2018

Phytotherapy Research

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Herbal products are popular among women during the perinatal period. St John's wort (SJW), Hypericum perforatum, is a common remedy for mild depression, a problem prevalent in this population. Although the safety of herbal products must be investigated, ethical issues constrain intervention studies in humans. Hence, animal studies often inform clinical decisions. The objective of this study is to systematically review rodent studies assessing the safety of SJW during the perinatal period. A literature search to November 10, 2017, identified 10 rodent studies that met a priori inclusion criteria. Study quality was evaluated according to both the Systematic Review Centre for Laboratory animal Experimentation tool for assessing bias and recommendations for appropriate reporting of herbal medicine research. Significant methodological limitations were found in each of the studies reviewed. These limitations include the lack of botanical verification and omission of extract characterization, inadequate explanation of dosage rationale, and absence of bias limiting protocols. Critical appraisal with contemporary tools indicates that each of the reviewed studies lacks appropriate rigour, rendering the results unreliable. Despite this, these papers are used in the rationale for recommending or contraindicating SJW during pregnancy and lactation.

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Section: Resultsmentioning

confidence: 99%