In vitro antibacterial effects of Zanthoxylum tingoassuiba root bark extracts and two of its alkaloids against multiresistant Staphylococcus aureus

Costa, Rafael S.; Lins, Manuela Oliveira; Hyaric, Mireille Le; Barros, Tânia Fraga; Velozo, Eudes da Silva

doi:10.1016/j.bjp.2016.11.001

Cited by 30 publications

(21 citation statements)

References 26 publications

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“…77 In 2017, a new glycoalkaloid, (−)-1-Oβ-D-glucoside-8-oxotetrahydropalmatine (199), isolated from tubers of S. succifera, exhibited antimicrobial activity against Staphylococcus aureus. 57 N-Methylcanadine (200) was isolated from Zanthoxylum tingoassuiba, 78 and demethylalangiside (201), alangiside (202), and isoalangiside (203) were identified and isolated from Ophiorrhiza nutans. 79 Subsequently, in 2018, it was shown that scoulerine (204) from Corydalis dubia exhibited promising suppression of cancer cell growth 81 (Figure 8).…”

Section: Protoberberine Isoquinoline Alkaloidsmentioning

confidence: 99%

“…Chelidonine 300 heitzii stem bark. 72 Furthermore, dihydrocheleryhtrine (312) was isolated from Z. tingoassuiba 78 and decarine (313) was identified from Zanthoxylum myriacanthum var. pubescens bark.…”

Section: Naphthylisoquinoline Alkaloidsmentioning

confidence: 99%

“…236 From 2014 to 2018, many publications have reported the antibacterial and antifungal activities of isoquinoline alkaloids; findings are briefly discussed below or listed in Table 3. 23,57,63,66,78,101 Berberine 161 peroxidation of membrane constituents. 237 Berberine also effectively protected mice infected with Salmonella typhimurium.…”

Section: Antibacterial and Antifungal Activitiesmentioning

confidence: 99%

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Biologically active isoquinoline alkaloids covering 2014–2018

Shang

Yang

Morris‐Natschke

et al. 2020

Medicinal Research Reviews

113

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Isoquinoline alkaloids, an important class of N-based heterocyclic compounds, have attracted considerable attention from researchers worldwide since the early 19th century. Over the past 200 years, many compounds from this class were isolated, and most of them and their analogs possess various bioactivities. In this review, we survey the updated literature on bioactive alkaloids and highlight research achievements of this alkaloid class during the period of 2014-2018. We reviewed over 400 molecules with a broad range of bioactivities, including antitumor, antidiabetic and its complications, antibacterial, antifungal, antiviral, antiparasitic, insecticidal, anti-inflammatory, antioxidant, neuroprotective, and other activities. This review should provide new indications or directions for the discovery of new and better drugs from the original naturally occurring isoquinoline alkaloids.

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Section: Protoberberine Isoquinoline Alkaloidsmentioning

confidence: 99%

Section: Naphthylisoquinoline Alkaloidsmentioning

confidence: 99%

Section: Antibacterial and Antifungal Activitiesmentioning

confidence: 99%

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Biologically active isoquinoline alkaloids covering 2014–2018

Shang

Yang

Morris‐Natschke

et al. 2020

Medicinal Research Reviews

113

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“…al.,2014), Z. rhoifolium (Tavares et. al.,2014), Z. acanthopodium (Devi et al, 2015), Z. alatum (Guleria et al, 2013, Z. tetraspermum (Nissanka et al, 2001), Z. caudatum (Nissanka et al, 2001, Z. ovalifolium (Pavani et al, 2015), Z. zanthoxyloides (Nana et al, 2015), Z. tingoassuiba (Costa et al,2016), Z. budrunga (Rahman et al,2008), Z.myriacanthum var. Pubescens (Li et al, 2014), and Z. leprieurii (Syn.…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial Activity of the Essential Oil of Zanthoxylum Avicennae

Andila¹

2019

BUM

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Minyak atsiri Zanthoxylum avicennae (Lam.) DC diektrak dari organ daun dan buah tanaman koleksi Kebun Raya “Eka Karya” Bali. Spesies ini dikoleksi dari Nusa Tenggara Barat pada 15 Juni 1993, dan kemudian di tanam di Kebun Raya “Eka Karya” Bali sejak 15 Desember 1993. Tujuan dari penelitian ini adalah untuk menggali sifat antibakteri dan antifungi dari minyak atsiri daun dan buah Z. avicennae. Untuk pengujian antimikroba, kedua minyak atsiri diuji dengan lima jamur patogen tanaman, yaitu Fusarium oxysforum(+), F. solani(+), Aspergilus niger(+), Collectotricum sp.(+), and Cladosporium sp. dan empat bakteri manusia yaitu Eschericia coli ATCC 43894, Salmonella typhimurium, E. coli (strain isolasi klinis), dan Staphylococcus aureus. Hasil penelitian mengungkapkan bahwa kedua minyak atsiri Z. avicennae (Minyak daun dan Buah) memiliki aktivitas antifungi yang kuat terhadap kelima jamur uji. Untuk uji antibakteri, Minyak atsiri daun menunjukkan hasil positif aktivitas antibacteri terhadap Eschericia coli, tetapi tidak terhadap bakteri Staphylococcus aureus. Sedangkan minyak atsiri buah menunjukkan hasil positive aktivitas antibakteri terhadap Shalmonella thipymurium and Eschericia coli atcc 43894. Kata kunci : Zanthoxylum avicennae, jamur patogen tanaman, bakteri, minyak atsiri; antimikroba.

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“…A casca do seu caule é utilizada na medicina tradicional, na forma de chás, como antimicrobiano (Detoni et al 2009), relaxante muscular (Silva et al 2008), antiparasitario, antinflamatório (Costa et al 2017b) analgésico, sudorífero e diurético (Pavarini 2000).…”

Section: Zanthoxylum Tingoassuiba a St Hilunclassified

Compostos químicos isolados de extratos e óleos essenciais do gênero Zanthoxylum Linnaeus (Rutaceae) e seu potencial antimicrobiano

Filho

Sousa

Santos

et al. 2020

Hoehnea

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RESUMO Este artigo de revisão reporta ao estudo químico e farmacológico de metabolitos secundários isolados de 20 espécies do gênero Zanthoxylum Linnaeus. Os constituintes químicos voláteis e fixos das espécies desse gênero foram isolados e caracterizados por métodos analíticos. Esta revisão foi realizada através da busca organizada de Dissertações de Mestrado, Teses de Doutorado e principalmente artigos científicos publicados sobre estudos fotoquímicos e atividades antimicrobianas das espécies do gênero Zanthoxylum disponíveis nos Periódicos CAPES, PubMed, ScienceDirect, Scopus, Scielo e Google Acadêmico entre 1985 e 2019. As espécies apresentaram composição química diversificada onde predominam alcaloides, terpenos e cumarinas com diferentes tipos de atividades antimicrobianas, tais como: antifúngica, antibiótica, antiprotozoário e antiviral.

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In vitro antibacterial effects of Zanthoxylum tingoassuiba root bark extracts and two of its alkaloids against multiresistant Staphylococcus aureus

Cited by 30 publications

References 26 publications

Biologically active isoquinoline alkaloids covering 2014–2018

Biologically active isoquinoline alkaloids covering 2014–2018

Antimicrobial Activity of the Essential Oil of Zanthoxylum Avicennae

Compostos químicos isolados de extratos e óleos essenciais do gênero Zanthoxylum Linnaeus (Rutaceae) e seu potencial antimicrobiano

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