Engineering spray-dried rosemary extracts with improved physicomechanical properties: a design of experiments issue

Chaul, Luíza Toubas; Conceição, Edemilson Cardoso da; Bara, Maria Teresa Freitas; Paula, José Realino de; Couto, Renê Oliveira do

doi:10.1016/j.bjp.2016.10.006

Cited by 26 publications

(28 citation statements)

References 32 publications

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“…From these values, HRs of the soup samples were calculated as 1.2 and 1.4 for S 2 and C 2 , respectively, indicating moderate cohesiveness of both the samples. CI values were 16.6% and 28.57%, for S 2 and C 2 , respectively, which indicate good flowability of the former and fair flowability of the latter, in agreement with the findings reported by Chaul et al () for spray‐dried powder of rosemary leaf extract.…”

Section: Resultssupporting

confidence: 91%

“…Among various physicochemical properties investigated, yield of LFS powder was found to be 72.3 ± 2.15% and BDs and TDs were estimated to be 0.20 ± 0.01 g/ml and 0.27 ± 0.01 g/ml, respectively. Therefore, CI and HR were calculated as 26% and 1.35, respectively, indicating moderate cohesiveness and fair flowability of the said samples, as has been reported by Chaul, Conceição, Bara, Paula, and Couto () in their study of spray‐dried powder of rosemary leaf extracts. LFS had prominent yellow color (Table ) and had an HLB value of 15.59 ± 1.17.…”

Section: Resultssupporting

confidence: 55%

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Lutein‐fortified potato soup and freeze‐dried lutein powder designed with supercritical carbon dioxide extract of yellow corn kernels are promising nutraceutical foods

Pal

Bhattacharjee

2019

J Food Process Preserv

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Yellow corn (Zea mays) kernels (fresh and preserved [120‐day stored]) were subjected to extraction of lutein employing supercritical carbon dioxide at 500 bar, 70°C for 90 min. The extract of preserved kernels possessed appreciably higher (21.42%) lutein content vis‐à‐vis that obtained from fresh samples. Either extract had desirable ratio of 3–3.47:1 of ω‐6/ω‐3 fatty acids. These extracts were then employed in designing new nutraceutical foods viz. a lutein‐rich food supplement (LFS) and a lutein‐fortified ready‐to‐eat potato soup with minimum loss of lutein during processing. Lutein contents of the LFS and the soup were 3.14 ± 0.16 mg/100 g (dry weight basis [d.b.]) and 1.09 ± 0.06 mg/100 g (d.b.), respectively, corresponding to 5.16% and 10.94% losses of lutein, respectively. These new designer lutein‐rich nutraceutical food products could be promising contributors of dietary lutein. Practical applications New nutraceuticals such as lutein‐fortified ready‐to‐eat potato soup and a freeze‐dried lutein‐rich food supplement have been developed using lutein‐rich SC‐CO2 extracts of yellow corn grits. It is opined that these value‐added designer products containing adequate amounts of lutein would act as safe alternatives of existing therapeutic drugs such as lutein capsule and are expected to enhance the daily dietary intake of lutein.

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Section: Resultssupporting

confidence: 91%

Section: Resultssupporting

confidence: 55%

Lutein‐fortified potato soup and freeze‐dried lutein powder designed with supercritical carbon dioxide extract of yellow corn kernels are promising nutraceutical foods

Pal

Bhattacharjee

2019

J Food Process Preserv

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“…For the present study, kaffir lime peels extract was prepared by different solvents, followed by an evaluation prior to the compression method for tablet preparation. Previous study [19] shows the best solvent to extract polyphenols from kaffir lime peels is ethanol 41%, therefore, it was firstly selected as the extraction solvent in the present experiment. To investigate any possibility to use other solvents, ethanol solution with different concentrations, i.e.…”

Section: Resultsmentioning

confidence: 99%

Design of kaffir lime peel extract tablets by direct compression: Effects of filler-binder on rheological properties

Irawaty

Hadisoewignyo

Wijaya

et al. 2019

EXPLORING RESOURCES, PROCESS AND DESIGN FOR SUSTAINABLE URBAN DEVELOPMENT: Proceedings of the 5th International Conference on E

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Dried kaffir lime peels from Citrus hystrix were extracted with ethanol by maceration method, followed by solvent evaporation to obtain dry extract. Due to economical aspect and good flow properties of the extract, a direct compression method was applied in making the tablets. The main objective of this study was to study the influence of filler-binder (Avicel PH 102, Emcompress and Lactose) on rheological properties of kaffir lime peel extract tablet dough. Firstly, kaffir lime peel extract was prepared by peeling, cutting and drying kaffir lime peels prior to soaking them to ethanol. After separating the solid part, the extract was subsequently concentrated and filler was added into the crude extract to obtain dry product. Secondly, dry extract was then combined with filler-binder, sweetener and lubricant prior to the compression. Rheological properties evaluated in this study were density, flow time, the Carr index and the Hausner ratio. Thirdly, the best formulation dough was compressed to produce tablets. From the results, it can be concluded that ethanol is the best solvent to extract polyphenols from kaffir lime peels. In addition, the use of a mixture of lactose and Avicel PH 102 as the filler-binder agent exhibited the best formulation.

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“…Since inflammation and circulating cytokines (TNF-α, IL-1β and IL-6) are among the mechanisms of retardation of diabetic wound healing [42], the anti-inflammatory effects of some plants of the herbal blend [43][44][45][46] may have a role in the promoted wound healing in the groups receiving the herbal extract or the tablet formulation. Meanwhile, the more prominent enhanced hypoglycemic and diabetic wound healing effect of the optimized tablet formulation may be attributed to the instant absorption, accurate dosing and induced chemical and microbiologic stability of the prepared tablets compared to the aqueous extract solution [47,48]. According to Allen et al, spray drying of the herbal blend have a positive role in the induced flowability of the pre-formulated tablet preparation [49].…”

Section: Discussionmentioning

confidence: 99%

Fast disintegrating tablets of spray dried poly-herbal extract: a promising hypoglycemic and diabetic wound healing activity.

Mahran

Hussein

Ahmed

et al. 2020

Journal of advanced Biomedical and Pharmaceutical Sciences

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Many herbal products have been used to control blood glucose level and minimize complications of diabetes mellitus. However, the feasibility of using such herbal product has been hindered due to the lower stability of their extracts and patients incompliance. Objective: An optimized fast disintegrating tablet preparation of spray dried aqueous extract of poly herbal blend has been formulated to maximize the therapeutic activity of such herbal extract. Methods: different ratios of superdisintegrants were evaluated in terms of reducing disintegration time and wetting time of the prepared formulations. The potential of the optimized formula in reducing blood glucose level and promoting wound healing in streptozotcin (STZ)-induced diabetic rats was determined. Key finding: Oral administration of the optimized formula (F6) had significant superior effect in reducing blood glucose level and promoting wound healing of diabetic rats compared receiving the aqueous extract of the herbal blend (P<0.05, p<0.01, respectively). That may be attributed to the enhanced stability and the accurate dosing of such solid dosage form. In addition, no remarkable toxic manifestations or histologic changes were observed in treated animals. Conclusion: These findings uncover the potential of the formulated dosage form in enhancing the hypoglycemic and wound healing activity of the herbal extract.

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Engineering spray-dried rosemary extracts with improved physicomechanical properties: a design of experiments issue

Cited by 26 publications

References 32 publications

Lutein‐fortified potato soup and freeze‐dried lutein powder designed with supercritical carbon dioxide extract of yellow corn kernels are promising nutraceutical foods

Lutein‐fortified potato soup and freeze‐dried lutein powder designed with supercritical carbon dioxide extract of yellow corn kernels are promising nutraceutical foods

Design of kaffir lime peel extract tablets by direct compression: Effects of filler-binder on rheological properties

Fast disintegrating tablets of spray dried poly-herbal extract: a promising hypoglycemic and diabetic wound healing activity.

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