Antioxidant α-amylase inhibitors flavonoids from Iris germanica rhizomes

Ibrahim, Sabrin R. M.; Alahdal, Abdulrahman M.; Khedr, Amgad I. M.; Mohamed, Gamal A.

doi:10.1016/j.bjp.2016.10.001

Cited by 27 publications

(20 citation statements)

References 36 publications

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“…This compound is not very common among all the Iris species and in fact its presence seems to be limited to only I. germanica L. [25,49]. This is the first time, for what we know, that it is reported in another species.…”

Section: Resultsmentioning

confidence: 76%

“…In fact, its presence seems to be restricted to two specific Iris species i.e., I. germanica L. without differentiating the geographical provenience of the plant [17,49] and I. kashmiriana Baker [50]. With this phytochemical study, it was shown that there is a third species in which it could be found and this is I. marsica I. Ricci and Colas.…”

Section: Resultsmentioning

confidence: 86%

“…This is the first time, for what we know, that it is reported in another species. From the pharmacological point of view, irigenin S (8) showed a moderate antioxidant activity [49].…”

Section: Resultsmentioning

confidence: 99%

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Isoflavones and Other Compounds from the Roots of Iris marsica I. Ricci E Colas. Collected from Majella National Park, Italy

Venditti¹,

Frezza²,

Rai³

et al. 2017

Med chem (Los Angeles)

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In this study, a phytochemical analysis was performed, for the first time, on Iris marsica I. Ricci e Colas. In particular, the attention was focused on the constituents of the roots. Twenty-one compounds were isolated by column chromatography and were analyzed/identified by NMR spectroscopy and mass spectrometry. They all own chemotaxonomic, ethno-pharmacological and nutraceutical relevance which allowed us to provide a phytochemical rationale, for the correct botanical classification of this species, for the employment of its roots in folk medicine like for all the other species belonging to the Iris genus and, lastly, for their further uses as food with important healthy benefits. All of these parts were broadly discussed about within the text.

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Section: Resultsmentioning

confidence: 76%

Section: Resultsmentioning

confidence: 86%

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Isoflavones and Other Compounds from the Roots of Iris marsica I. Ricci E Colas. Collected from Majella National Park, Italy

Venditti¹,

Frezza²,

Rai³

et al. 2017

Med chem (Los Angeles)

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“…The assay was carried out using α‐amylase by EnzCheck ® Ultra Amylase Assay Kit (E33651) as previously outlined (Ibrahim, Mohamed, Abdel‐Latif, et al, ; Ibrahim, Mohamed, Zayed, et al, ; Ibrahim, Al‐Ahdal, et al, ; Mohamed, ).…”

Section: Methodsmentioning

confidence: 99%

α‐Amylase inhibition of xanthones fromGarcinia mangostanapericarps and their possible use for the treatment of diabetes with molecular docking studies

et al. 2019

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Chromatographic separation of the methanol extract of Garcinia mangostana (mangosteen, Guttiferae) dried pericarps led to the isolation and structural characterization of a new xanthone, namely garcimangostin A (5), together with garcixanthone A (1), gartanin (2), normangostin (3), and garcinone C (4). Their structural characterization was achieved using various NMR spectroscopic tools as well as HRMS. Their α‐amylase inhibitory (AAI) potential was assessed. It is noteworthy that 5 had the most potent inhibitory effect with % inhibition 94.1 compared to acarbose (96.7%). Moreover, the molecular modeling studies were estimated. The observed scoring results correlated to those results of the AAI assay. Interestingly, 5 was completely fitting with acarbose structure and a superimposition of acarbose complexed structure with 5 in the enzyme binding site was observed. The AAI activity of 5 could be attributed to the xanthone moiety insertion in the active site of the enzyme via H‐bonds network and pi–pi interactions. Practical applications Garcinia mangostana is a widely consumed fruit for its unique pleasant aroma and sweet taste. Also, it contains valuable nutritious compounds that are advantageous for human body. It is used as various traditional medicines for treating several ailments such as skin infection, hyperkeratosis, eczema, wounds, psoriasis, amebic dysentery, cholera, diarrhea, and suppuration. The findings of this work can demonstrate the significant AAI potential of G. mangostana xanthones. Therefore, mangosteen as a functional food could help in lowering the postprandial glucose absorption and identifying lead compounds from α‐amylase inhibition for the treatment and/or prevention of diabetes and obesity.

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“…Coleopteran, Indole, methyl acarviosin, Isoflavonoids and flavonoids recently reported inhibitors for alpha amylase [8][9][10][11]. Inhibitors of this enzyme can slow down carbohydrate absorption prolonging total carbohydrate absorption time, decreasing the rate of glucose absorption and, subsequently, reducing the postprandial plasma glucose increase.…”

Section: Introductionmentioning

confidence: 97%