Comparative study of Passiflora taxa leaves: II. A chromatographic profile

Wosch, Luma; Santos, Kely Cristina dos; Imig, Daniela Cristina; Santos, Cid Aimbiré de Moraes

doi:10.1016/j.bjp.2016.06.007

Cited by 25 publications

(5 citation statements)

References 17 publications

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“…A comparative metabolite profiling and fingerprinting of the genus Passiflora leaves were reported using a multiplex approach of UPLC-MS and NMR analyzed by chemometric tools [ 41 ]. Thin layer chromatography can also be used in order to differentiate species [ 42 ]. Recently, new components were isolated and identified in the fruit peel of Passiflora edulis , including five flavonoids [ 43 , 44 ].…”

Section: Methodsmentioning

confidence: 99%

“…Based on studies that indicate the presence of flavonoids in extracts of Passiflora and their pharmacological properties, a total flavonoid analysis has been proposed for the preliminary evaluation of this plant species [42,[45][46][47][48][49]. Furthermore, the C-glycosylated flavonoid may represent a particularly important chemical marker for the quality control of herbal medicines, enabling the identification of different species of Passiflora [46,50,51].…”

Section: Chemical Constituentsmentioning

confidence: 99%

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Herbal Medicinal Products fromPassiflorafor Anxiety: An Unexploited Potential

Fonseca

Rodrigues

Ramos

et al. 2020

The Scientific World Journal

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Herbal medicines containing Passiflora species have been widely used to treat anxiety since ancient times. The species Passiflora incarnata L. is included in many Pharmacopoeias, and it is the most used species in food, cosmetic, and pharmaceutical industries. However, there are around 600 species of the genus Passiflora and probably other species that can be used safely. Thus, this article was based on a search into the uses of the main species of the genus Passiflora with anxiolytic activity and its main secondary metabolites and some pharmacological studies, patents, and registered products containing Passiflora. Furthermore, the Brazilian Regulatory Health Agency Datavisa, Medicines and Healthcare Products Regulatory Agency of the United Kingdom, and the European Medicines Agency websites were consulted. The results showed that Passiflora species have health benefits but clinical trials are still scarce. The complexity of Passiflora extracts creates challenges for the development of herbal medicines. P. incarnata is the most studied species of the genus and the most used in natural anxiolytic herbal medicine formulations. However, there are hundreds of Passiflora species potentially useful for medicinal and nutraceutical purposes that are still little explored.

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Section: Methodsmentioning

confidence: 99%

Section: Chemical Constituentsmentioning

confidence: 99%

Herbal Medicinal Products fromPassiflorafor Anxiety: An Unexploited Potential

Fonseca

Rodrigues

Ramos

et al. 2020

The Scientific World Journal

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“…To corroborate with these observations, it was previously shown that ExEt had a high amount of phenolic compounds and flavonoids using the HPLC analyzis [24]. [23] Reported that most of the biological activities of Passiflora species, such as antioxidant, anticancer, anti-inflammatory, cardioprotective, antithrombotic, hypoglycemic and antihyperglycemic effects, as well as their role in preventing cellular lipoperoxidation and improving the endothelial function [25,26], are attributed to the presence of phenolic and flavonoid compounds.…”

Section: Phytochemical Characterizationmentioning

confidence: 69%

Glycemic Regulation and Cytotoxic Characteristics of the Ethyl Acetate Fraction from <em>Passiflora cincinnata</em> Mast Leaves

Estrevam¹,

Lima²,

Santos³

et al. 2017

Preprint

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Passiflora cincinnata Mast is a plant popularly used in traditional medicine in northeastern Brazil. The present study aimed to evaluate the anti-lipoperoxidative and anti-α-amylase properties, and cytotoxicity of an extract and fraction of passion fruit leaves (P. cincinnata Mast), as well as the antihyperglecemiant activity of the fraction rich in glycosylated flavonoids and showing low cytotoxicity in rats with a postprandial hyperglycaemia condition. The ethyl acetate fraction (F.ACT) of the P. cincinnata leaves presented the best anti-lipoperoxide properties with TBARs 81.49%, 95.48% and 75.62% lower than AAPH, FeSO4 and H2O2 induced controls, respectively, at 200 μg.mL -1

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“…Most of them are classified as C-glucolsyl flavonoids derived from apigenin and luteolin, and frequently found as isomers (Ozarowski et al, 2018). Some authors have already reported the presence of the flavonoids orientin, isoorientin, vitexin, vitexin-2´´-O-rhaminoside and isovitexin, as well as acid ascorbic, polyamines, terpenes and carotenoids, in leaf and fruit pulp extracts from P. setacea and in its cultivar BRS Pérola do Cerrado (Santana et al, 2015;Bomtempo et al, 2016;Gomes et al, 2017;Wosch et al, 2017;Carvalho et al, 2018;Sanchez et al, 2020;da Rosa et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Flavonoid content and antioxidant potential of leaf extracts of Passiflora setacea cv BRS Prola do Cerrado, a new wild passion fruit cultivar

Raphaela¹,

Renata²,

Fonseca³

et al. 2022

J. Med. Plants Res.

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Passiflora setacea D.C. is a wild species native to the Brazilian Cerrado, with agronomic and medicinal potentials. The cultivar BRS Pérola do Cerrado is the first registered and protected cultivar of a wild Passiflora and has become an alternative to the passion fruit market due to its desirable characteristics for food, ornamental and pharmaceutic industries. Since plant tissue culture techniques are considered important tools for large-scale production of plants and bioactive compounds, the goal of this work was to evaluate the flavonoid content and the antioxidant potential of hydroethanolic leaf extracts from in vivo and micropropagated plants of this new cultivar. Phytochemical analysis was performed by HPLC-UV-ESI-MS/TOF. Antioxidant activity was evaluated by the DPPH and the iron-chelating assays. The activities of antioxidant enzymes catalase, superoxide dismutase and ascorbate peroxidase (CAT, SOD and APX) were also determined. Two di-C-glucosyl flavonoids derivatives from apigenin were registered as major constituents in both leaf extracts analyzed and were identified as vicenin-2 and schaftoside. Despite the low antioxidant potential observed by the DPPH assay, leaf extracts from both in vivo and micropropagated plants showed high chelating capacity. Although no differences in the activity of SOD and CAT were observed, the specific activity of APX was increased in leaf extracts of micropropagated plants. These results suggest that in vitro plants can be used as an alternative for flavonoid production from cultivar BRS Pérola do Cerrado.

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Comparative study of Passiflora taxa leaves: II. A chromatographic profile

Cited by 25 publications

References 17 publications

Herbal Medicinal Products fromPassiflorafor Anxiety: An Unexploited Potential

Herbal Medicinal Products fromPassiflorafor Anxiety: An Unexploited Potential

Glycemic Regulation and Cytotoxic Characteristics of the Ethyl Acetate Fraction from <em>Passiflora cincinnata</em> Mast Leaves

Flavonoid content and antioxidant potential of leaf extracts of Passiflora setacea cv BRS Prola do Cerrado, a new wild passion fruit cultivar

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