Hypoglycemic effect of formulation containing hydroethanolic extract of Calophyllum brasiliense in diabetic rats induced by streptozotocin

Abstract

a b s t r a c tDiabetes mellitus is a chronic and severe metabolic dysfunction, it's slow and progressive evolution interferes directly in the metabolism of carbohydrates, fats and proteins, causing hyperglycemia, glycosuria, polydipsia, hyperlipidaemia, among others. The aim of this study was to evaluate the antidiabetic effect of hydroethanolic extract and granulated of Calophyllum brasiliense Cambess., Clusiaceae, species in diabetic rats as well as it's biochemical parameters. The results demonstrated that both the pharmaceutical forms, hydroethanolic extract and granulated, were able to reduce significantly (p < 0.001) hyperglycemia and glycosuria, in addition to improve polydipsia, polyuria, and weight loss. Treatments using hydroethanolic extract and granulated were also able to reduce significantly levels of triacylglycerides, cholesterol and low-density lipoprotein, as well as the transaminases, urea and creatinine levels. Therefore, it is concluded that these pharmaceutical forms have anti-diabetic effect and act improving the biochemical parameters, this effect is probably due to the high content of polyphenolic compounds found in the formulations.

The hypoglycemic effect of extract/fractions from Fuzhuan Brick‐Tea in streptozotocin‐induced diabetic mice and their active components characterized by LC‐QTOF‐MS/MS

“…In this study, all total extract and fractions from Fuzhuan Brick-Tea presented effect on glucose metabolism. However, this improvement did not reduce blood glucose levels to basal values as observed in mice of group N. The phenomenon may be associated with destruction of pancreatic β cells caused by STZ (Carvalho et al, 2016).…”

The effects of Rosmarinus officinalis L. essential oil and its nanoemulsion on dyslipidemic Wistar rats

“…EORO composition is based on volatile compounds, mainly monoterpenes (Fernandes et al, 2013). Its characterization can be assessed through chromatographic and spectroscopic techniques to identify and quantify its major compounds (Carvalho et al, 2016). Our essential oil from R. officinalis was composed mainly of 1,8-cineole (33.70%), camphor (27.68%), limonene (21.99%), and α-pinene (8.13%), with is similar with the literature reporting α-pinene, camphor, 1,8-cineole, and limonene as major compounds (Fernandes et al, 2013; Borges et al, 2017).…”

Dillenia indica L. attenuates diabetic nephropathy via inhibition of advanced glycation end products accumulation in STZ-nicotinamide induced diabetic rats

“…Botanical name of the plant was verified from published literature and database. 22 500 g of powdered dried leaves were subjected to Soxhlet extraction sequentially using petroleum ether 60–80 °C, chloroform, ethanol and hydro-alcohol (40 %) in a ratio of (1:8 w/v ) 23 . The extractive solution was filtered through filter paper, dried under vacuum yielding 17.67 % of alcohol (DAE) and 9.43 % hydro-alcohol extract (DHE).…”