Profile of bioactive compounds of Capparis spinosa var. aegyptiaca growing in Egypt

Bakr, Riham O.; Bishbishy, Mahitab H. El

doi:10.1016/j.bjp.2016.04.001

Cited by 35 publications

(21 citation statements)

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“…Antimicrobial activity of C. spinosa has been reported previously using different types of extracts and plant parts against different types of microorganisms [11,12,[16][17][18][19]. According to the previously conducted studies, diverse phytochemical compounds are the active ingredients of C. spinosa plant [6][7][8][9][10]13].…”

Section: Discussionmentioning

confidence: 99%

“…Phytochemical analysis showed that this plant has high quantities of numerous bioactive ingredients and molecules, which are responsible for different pharmacological activities. These activities include antioxidant effect [6,[8][9][10], antifungal effect [11], phytotoxic effect [11][12], anticancer [9,[13][14], nephrotoxicity and hepatotoxicity effects [15], antibacterial effect [12,[16][17][18][19], antimutagenic effect [20]. Other pharmacological effects have also been reported.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Antimicrobial activity and Genotoxic Potential of Capparis spinosa (L.) Plant Extracts

Adwan

Omar

2021

MRJI

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Objective: The aims of this study were to evaluate the antimicrobial activity and the genotoxic effect of both ethanolic and aqueous extracts of stem and leaf of Capparis spinosa (C. spinosa) plant on Escherichia coli (E. coli) ATCC 25922, Staphylococcus aureus (S. aureus) ATCC 6538P, clinical isolate of Methicillin-resistant S. aureus (MRSA) and Klebsiella pneumoniae (K. pneumoniae) and Candida albicans (C. albicans) ATCC 90028. Materials and Methods: The antimicrobial activity was determined using microbroth dilution method, while the genotoxic effect was investigated using randomly amplified polymorphic DNA (RAPD)-PCR and enterobacterial repetitive intergenic consensus (ERIC)-PCR. Results: The MIC values of both ethanolic and aqueous leaf and stem extracts of C. spinosa plant had a range 6.25 mg/ml to 100 mg/ml. In addition, it was found that ethanolic extract more effective than aqueous extract. The genotoxic activity of aqueous leaf extract, showed changes in both Random Amplified Polymorphic DNA (RAPD)-PCR and Enterobacterial Repetitive Intergenic Consensus (ERIC)-PCR profiles of E. coli strain treated with extract compared to untreated (negative) control. These changes included an alteration in the intensity, absence or appearance of new amplified fragments. Conclusions: Results of this study strongly show the genotoxic effect of aqueous leaf extract from C. spinosa plant on E. coli. The findings draw awareness to the possible toxic effect use of C. spinosa plant in traditional medicine and point out the capability of using C. spinosa to treat bacterial or fungal infections. More studies are needed to detect the exact ingredients of this plant as well as the mechanisms responsible for genotoxicity. Further in vivo genotoxicity studies are recommended to ensure and to evaluate the safety of using plants for therapeutic purposes. In addition, results of this study showed that molecular fingerprinting based on ERIC-PCR can be used to evaluate the genotoxic effect in the model bacterial species E. coli.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of Antimicrobial activity and Genotoxic Potential of Capparis spinosa (L.) Plant Extracts

Adwan

Omar

2021

MRJI

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“…Other compounds present in the Hex extract such as 6,10-dimethyl-2-undecanone and 3-(4-hydroxyphenyl)propionitrile were identified (see Table 7). The first compound has a cytotoxic effect on the breast cancer cell lines [69]. A compound similar to 3-(4-hydroxyphenyl)propionitrile presents β-oestrogen receptor-selective inhibition which is important for breast cancer cells [70, 71].…”

Section: Discussionmentioning

confidence: 99%

In vitro antioxidant and antiproliferative effect of the extracts of Ephedra chilensis K Presl aerial parts

Mellado

Soto

Madrid

et al. 2019

BMC Complement Altern Med

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Background: Ephedra chilensis K Presl, known locally as pingo-pingo, is a Chilean endemic plant used in traditional medicine as an anti-inflammatory and used in other treatments. However, unlike for the other Ephedra species, there have been no reports on the antioxidant and cytotoxic effects of this plant. The present study aims to explore the potential applications of E. chilensis extract as a cytotoxic agent against in vitro cancer cell lines and to explore the relationship between this extract and antioxidant activity. Methods: Total anthraquinone, flavonoid, and phenolic contents, as well as antioxidant activity (DPPH, FRAP, and TRAP assays) and cytotoxic effect on several cancer cell lines (MCF-7, PC-3, DU-145, and HT-29) were measured for the hexane, dichloromethane and ethanol extracts of E. chilensis. In addition, several correlations among the phytochemical content, antioxidant activity, and cytotoxic effect were evaluated. Finally, GC-MS analyses of the most active extracts were carried out to identify their major components and to relate these components to the cytotoxic effect. Results: Antioxidant activity was found in the EtOH extracts of Ephedra, and the results were correlated with the phenolic content. For the cytotoxic activity, the non-polar extracts of E. chilensis had the highest antiproliferative effect for the MCF-7 and PC-3 cancer lines; the extract was shown to be up to three times more selective than doxorubicin. However, the cytotoxic effect was not correlated with the antioxidant activity. Lastly, the GC-MS analysis showed a high concentration of saturated fatty acids (mainly n-hexadecanoic acid) and terpenoids (mainly 4-(hydroxy-ethyl)-γbutanolactone). Conclusion: The cytotoxic activity and selectivity of the non-polar extracts of E. chilensis for the MCF-7 and PC-3 cell lines could be related to the terpenic compounds and fatty acids of the extracts or to the synergistic effect of all of the compounds in the extracts. These non-polar extracts can be used for the development of new drugs against breast and prostate cancer.

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“…Mollica et al (2017) reported a significant decrease in fasting blood glucose levels and glycosylated hemoglobin in treated patients when compared to control group; triglyceride levels also decreased in a significant manner, without causing kidney toxicity or other side effects. Cytotoxic activity of the plant was also assessed, being observed a high selectivity against human cancer cell lines, namely: breast adenocarcinoma (MCF-7), hepatocellular carcinoma (Hep-G2), and colon carcinoma (HCT-116 and HT-29) cells, suggesting their upcoming use as a promissory candidate for nutraceutical researches (Bakr & Bishbishy, 2016). Anthelmintic effects of the species were also reported as being related to its phenolic content and antioxidant activity (Akkari et al, 2016).…”

Section: Health Effectsmentioning

confidence: 98%

Edible halophytes of the Mediterranean basin: Potential candidates for novel food products

Petropoulos

Karkanis

Martins

et al. 2018

Trends in Food Science & Technology

125

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Background: Recent trends in the food science industry and consumers' preferences for diversified diets suggest the consumption of wild greens not only as diet complements but also as healthy and functional foods for targeted conditions, rendering its commercial cultivation of major importance in order to avoid irrational gathering and genetic erosion threats. The Mediterranean basin abounds in wild edible species which have been used for food and medicinal purposes by human throughout the centuries. Many of these species can be found near coastal areas and usually grow under saline conditions, while others can adapt in various harsh conditions including high salinity. Scope and approach: The aim of this review focuses on listing and describing the most important halophyte species that traditionally have been gathered by rural communities of the Mediterranean basin, while special interest will be given on their chemical composition and health promoting components. Cases of commercially cultivated halophytes will be also presented to highlight their potential as alternative cash crops, while results from in vitro and in vivo health effects will be presented. Key findings and conclusions: The recent literature has provided useful information regarding the potential of wild halophytes as promising ingredients in functional food products and/or as sources of bioactive compounds. However, further research is needed regarding the chemical characterization of these species under commercial cultivation practices, while further clinical and model trials have to be conducted to assess their long term bioactivity and elucidate potential toxic effects and regulations of safe consumption.

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Profile of bioactive compounds of Capparis spinosa var. aegyptiaca growing in Egypt

Cited by 35 publications

References 39 publications

Evaluation of Antimicrobial activity and Genotoxic Potential of Capparis spinosa (L.) Plant Extracts

Evaluation of Antimicrobial activity and Genotoxic Potential of Capparis spinosa (L.) Plant Extracts

In vitro antioxidant and antiproliferative effect of the extracts of Ephedra chilensis K Presl aerial parts

Edible halophytes of the Mediterranean basin: Potential candidates for novel food products

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