Folk medicine, phytochemistry and pharmacological application of Piper marginatum

Brú, Jennifer; Guzman, Juan

doi:10.1016/j.bjp.2016.03.014

Cited by 23 publications

(18 citation statements)

References 35 publications

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“…have been used by man, manly as spices, in mystical and cultural activities and in folk medicine to treat many diseases. For example, a decoction of the leaves of P. cavalcantei is considered by native Amazon people as excellent antipyretic and analgesic [ 6 ]; P. marginatum , which is used by indigenous communities in Central America, the Antilles, and South America for gastrointestinal problems [ 7 ]; and P. umbellatum that is traditionally used as an anti-inflammatory in Brazil, to treat wounds in Cuba, and to treat fever in Peru [ 8 ]. In the literature, there have been many studies about Asian Piper species, but a large proportion of the information has been generated from Latin American species, pointing to an enormous diversity of chemical compounds associated with its diversity of biological activities [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Essential Oils from Neotropical Piper Species and Their Biological Activities

Silva

et al. 2017

IJMS

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The Piper genus is the most representative of the Piperaceae reaching around 2000 species distributed in the pantropical region. In the Neotropics, its species are represented by herbs, shrubs, and lianas, which are used in traditional medicine to prepare teas and infusions. Its essential oils (EOs) present high yield and are chemically constituted by complex mixtures or the predominance of main volatile constituents. The chemical composition of Piper EOs displays interspecific or intraspecific variations, according to the site of collection or seasonality. The main volatile compounds identified in Piper EOs are monoterpenes hydrocarbons, oxygenated monoterpenoids, sesquiterpene hydrocarbons, oxygenated sesquiterpenoids and large amounts of phenylpropanoids. In this review, we are reporting the biological potential of Piper EOs from the Neotropical region. There are many reports of Piper EOs as antimicrobial agents (fungi and bacteria), antiprotozoal (Leishmania spp., Plasmodium spp., and Trypanosoma spp.), acetylcholinesterase inhibitor, antinociceptive, anti-inflammatory and cytotoxic activity against different tumor cells lines (breast, leukemia, melanoma, gastric, among others). These studies can contribute to the rational and economic exploration of Piper species, once they have been identified as potent natural and alternative sources to treat human diseases.

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Section: Introductionmentioning

confidence: 99%

Essential Oils from Neotropical Piper Species and Their Biological Activities

Silva

et al. 2017

IJMS

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“…The general metabolism of phenylpropanoid 3 can generate an enormous array of secondary metabolites (flavonoids, coumarins, lignins, hydrolyzable tannins) based on the few intermediates of the shikimate pathway as the core unit [ 20 ]. Phenylalkanoids like 4 act as chemotaxonomy markers and exhibit antifungal activity [ 21 ]. The porphyrinic compounds (such as phaeophytin a) are derived from chlorophyll a and are widely present in the plant kingdom [ 22 ].…”

Section: Resultsmentioning

confidence: 99%

Isolation of Monoterpene Dihydrochalcones from Piper montealegreanum Yuncker (Piperaceae)

et al. 2017

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Four new compounds were isolated from the branches of Piper montealegreanum Yuncker, a shrub found in the Amazon rainforest, including two new dihydrochalcones named claricine (1) and maisine (2), a cinnamic acid derivative 3 and a phenylalkanoid 4, along with a porphyrin identified as the known compound phaeophytin a (5). The structures were established using spectroscopic experiments, including 1D and 2D NMR and HRESIMS experiments, performed on the two monoterpene dihydrochalcones and their monoacetyl derivatives. The structural diversity of these substances is very important for the Piper genus chemotaxonomy.

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“…Piper marginatum Jacq is a plant belonging to the Piperaceae family. In Colombia, it is known as “tooth-healer” or “small cord” [ 27 , 28 , 36 ]. On the other hand, Ilex guayusa Loes, known as “guayusa,” is a native plant of the neotropics with natural distribution in Colombia, Ecuador, Peru, Bolivia, and Brazil [ 29 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Activity ofPiper marginatumJacq andIlex guayusaLoes on Microorganisms Associated with Periodontal Disease

Gamboa

Muñoz

Numpaque

et al. 2018

International Journal of Microbiology

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Background Chronic periodontitis is a multifactorial infectious disease, where multiple bacteria, such as Porphyromonas gingivalis, Prevotella intermedia, and Fusobacterium nucleatum are implicated. The main purpose of researching natural products is to find substances or compounds with antimicrobial activity. Aim The objective of this work was to determine antimicrobial activity from extracts and obtained fractions from Piper marginatum Jacq and Ilex guayusa Loes on P. gingivalis ATCC 33277, F. nucleatum ATCC 25586, and P. intermedia ATCC 25611. Methods Total ethanol extracts were obtained from both plants. Fractions were obtained from total ethanol extracts with amberlite as a stationary phase employing hexane, acetone, and ethanol-water as solvents. Qualitative and quantitative phytochemical characterization was performed on total ethanol extracts from both plants. Antimicrobial activity from total ethanol extracts and fractions from both plants were evaluated on P. gingivalis ATCC 33277, F. nucleatum ATCC 25586, and P. intermedia ATCC by the well diffusion method with Wilkins–Chalgren agar. Results Piper marginatum Jacq total ethanol extract presented antimicrobial activity against all three bacteria, whereas Ilex guayusa Loes was only efficient against P. gingivalis ATCC 33277 and P. intermedia ATCC 25611, with inhibition halos from 9.3 to 30 mm. Ilex guayusa Loes obtained fractions presented antimicrobial activity against all three microorganisms evaluated, with inhibition halos ranging from 9.7 to 18.7 mm. In regards to Piper marginatum Jacq fractions, inhibition halos were between 8.3 and 19 mm, against all three microorganisms evaluated; only hexane fraction did not present antimicrobial activity against F. nucleatum ATCC 25586. Conclusion Piper marginatum Jacq and Ilex guayusa Loes total ethanol extracts and fractions presented outstanding antimicrobial activity against P. gingivalis ATCC 33277, P. intermedia ATCC 25611, and F. nucleatum ATCC 25586.

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Folk medicine, phytochemistry and pharmacological application of Piper marginatum

Cited by 23 publications

References 35 publications

Essential Oils from Neotropical Piper Species and Their Biological Activities

Essential Oils from Neotropical Piper Species and Their Biological Activities

Isolation of Monoterpene Dihydrochalcones from Piper montealegreanum Yuncker (Piperaceae)

Antimicrobial Activity ofPiper marginatumJacq andIlex guayusaLoes on Microorganisms Associated with Periodontal Disease

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