GABAergic effect of valeric acid from Valeriana wallichii in amelioration of ICV STZ induced dementia in rats

Vishwakarma, Shilpa; Goyal, Rohit; Gupta, Varun; Dhar, K.L.

doi:10.1016/j.bjp.2016.02.008

Cited by 24 publications

(15 citation statements)

References 23 publications

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“…The dosage of Val used in this study did not show any toxicity and it was selected based on previous study [ 40 ]. Antioxidant enzymes plays a major role in scavenging reactive oxygen species which is a product of oxidative metabolism.…”

Section: Resultsmentioning

confidence: 99%

“…Group III (rotenone+ Val): Immediately before treatment, Val (40 mg/kg, i.p) was prepared and administered once daily for four weeks, 30 min prior to ROT administration. Dosage fixed for Val was based on previous study [ 40 ]. Group IV received only intraperitoneal injection of Val (40 mg/kg, i.p) once daily for four weeks and served as drug control.…”

Section: Methodsmentioning

confidence: 99%

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Valeric Acid Protects Dopaminergic Neurons by Suppressing Oxidative Stress, Neuroinflammation and Modulating Autophagy Pathways

Jayaraj

Azimullah

et al. 2020

IJMS

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Parkinson’s disease, the second common neurodegenerative disease is clinically characterized by degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) with upregulation of neuroinflammatory markers and oxidative stress. Autophagy lysosome pathway (ALP) plays a major role in degradation of damaged organelles and proteins for energy balance and intracellular homeostasis. However, dysfunction of ALP results in impairment of α-synuclein clearance which hastens dopaminergic neurons loss. In this study, we wanted to understand the neuroprotective efficacy of Val in rotenone induced PD rat model. Animals received intraperitoneal injections (2.5 mg/kg) of rotenone daily followed by Val (40 mg/kg, i.p) for four weeks. Valeric acid, a straight chain alkyl carboxylic acid found naturally in Valeriana officianilis have been used in the treatment of neurological disorders. However, their neuroprotective efficacy has not yet been studied. In our study, we found that Val prevented rotenone induced upregulation of pro-inflammatory cytokine oxidative stress, and α-synuclein expression with subsequent increase in vital antioxidant enzymes. Moreover, Val mitigated rotenone induced hyperactivation of microglia and astrocytes. These protective mechanisms prevented rotenone induced dopaminergic neuron loss in SNpc and neuronal fibers in the striatum. Additionally, Val treatment prevented rotenone blocked mTOR-mediated p70S6K pathway as well as apoptosis. Moreover, Val prevented rotenone mediated autophagic vacuole accumulation and increased lysosomal degradation. Hence, Val could be further developed as a potential therapeutic candidate for treatment of PD.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Valeric Acid Protects Dopaminergic Neurons by Suppressing Oxidative Stress, Neuroinflammation and Modulating Autophagy Pathways

Jayaraj

Azimullah

et al. 2020

IJMS

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“…Administration of Wistar Albino rats with 20 and 40 mg/kg valeric acid i.p. significantly decrease escape latency and retention transfer latency, as compared with intracerebroventricular‐streptozotocin group (Vishwakarma, Goyal, Gupta, & Dhar, ). Likewise, isopatrinioside ( 193 ) isolated from V. jatamansi revealed moderate neuroprotective effects against CoCl 2 ‐induced neuronal cell death in PC12 cells (Tan et al, ).…”

Section: Medicinal Uses and Pharmacology Propertiesmentioning

confidence: 94%

“…Valeric acid ( 325 ) isolated from V. jatamansi possesses similar structure to the neurotransmitter GABA and act as an NMDA‐receptor antagonist by displaying the neuroprotective effect through amelioration of intracerebroventricular streptozotocin induced neurodegeneration in Wistar rats (Vishwakarma et al, ). Valeric acid ( 325 ) was isolated from dichloromethane extract of coarsely powdered rhizomes of V. jatamansi and characterized using Fourier‐transform infrared spectroscopy.…”

Section: Medicinal Uses and Pharmacology Propertiesmentioning

confidence: 99%

Valeriana jatamansi: An herbaceous plant with multiple medicinal uses

Jugran

Rawat

Bhatt

et al. 2019

Phytotherapy Research

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Valeriana jatamansi Jones (Family: Caprifoliaceae), a high value medicinal plant, was distributed in many countries of Asia. The species possesses important valepotriates and is a good source of flavones or flavone glycosides, lignans, sesquiterpenoids or sesquiterpenoid glycoside, bakkenolide type sesquiterpenoids, phenolic compounds, terpinoids, etc. The use of the species in traditional and modern medicines is well known. For instance, V. jatamansi is very important for its insect repelling and antihelmethic properties. Similarly, sedative, neurotoxic, cytotoxic, antidepressant, antioxidant, and antimicrobial activities of the species in various ailments in the indigenous system of medicine, particularly in Asia, are reported. This review focuses on the detailed phytochemical composition, medicinal uses, and pharmacological properties of V. jatamansi along with analysis of botanical errors in published literature and reproducibility of the biomedical researches on this multipurpose herbaceous species.

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“…It is constituted of two opposite open arms (50 cm × 10 cm), crossed with two closed arms of the same dimensions with 40 cm high walls. The arms were connected by a central square (10 cm × 10 cm) and the apparatus was elevated 70 cm from the floor [17]. Memory acquisition and retention were tested using elevated plus maze test on days 23 and 24.…”

Section: Elevated Plus Mazementioning

confidence: 99%

Pharmacological Evaluation of Triphala Churna Instreptozotocin (I. C. V.) Induced Dementia in Rats

Deka¹,

Kumar²

2018

Int J Pharm Pharm Sci

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Objective: The objective of the study was to investigate the memory improving activity of Triphala Churna hydro-methanolic fruit extract on learning and memory functions in Streptozotocin (I. C. V) induced dementia in rats by using morris water maze and elevated plus maze.Methods: A total of 42 albino wistar rats weighing 80-100 g were randomized into 7 equal groups as follows: Normal control group received normal saline (1 ml/kg p. o.) for 24 d, STZ treated group (3 mg/kg, i. c. v) were administered in two dosage regimen i.e. on first day and third day.), Standard group: Streptozotocin (3 mg/kg i. c. v)+Vitamin E (100 mg/kg/day p. o.) were administered for 21 d, Standard group: Streptozotocin (3 mg/kg i. c. v)+Rivastigmine (2 mg/kg/day p. o.) were administered for 21 d. The learning and memory-impaired rats were treated with Triphala Churna Formulation 1, Triphala Churna Formulation 2 and Triphala Churna Formulation 3 for 21 d (100 mg/kg p. o.). AchE activity, lipid peroxidation, superoxide dismutase, glutathione level of brain homogenate was estimated in Control/STZ (I. C. V)/Standard/Triphala Churna fruits extract treated rats.Results: Administration of Triphala Churna fruits extract significantly restored learning and memory impairment induced by STZ (I. C. V) in the elevated plus maze and morris water maze. Furthermore, in the TPLC F2 and TPLC F3 treated group brain AchE level was decreased (P≤0.01) as well as brain lipid peroxidation was also decreased (P≤0.001). Brain antioxidant enzymes such as glutathione level were increased (P≤0.001) in the TPLC1 and TPLC2 treated group when compared to the STZ treated group, TPLC F2 and TPLC F3 treated group showed significant (P≤0.001, P≤0.01) increase in superoxide dismutase level. Conclusion: Triphala Churna fruits extract has an improving effect on learning and memory impairment rats produced by Streptozotocin (I. C. V) and may have a useful effect in the treatment of dementia and Alzheimer's disease.

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GABAergic effect of valeric acid from Valeriana wallichii in amelioration of ICV STZ induced dementia in rats

Cited by 24 publications

References 23 publications

Valeric Acid Protects Dopaminergic Neurons by Suppressing Oxidative Stress, Neuroinflammation and Modulating Autophagy Pathways

Valeric Acid Protects Dopaminergic Neurons by Suppressing Oxidative Stress, Neuroinflammation and Modulating Autophagy Pathways

Valeriana jatamansi: An herbaceous plant with multiple medicinal uses

Pharmacological Evaluation of Triphala Churna Instreptozotocin (I. C. V.) Induced Dementia in Rats

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