Isolation and characterization of flavanols from Anthocephalus cadamba and evaluation of their antioxidant, antigenotoxic, cytotoxic and COX-2 inhibitory activities

Chandel, Madhu; Kumar, Manish; Sharma, Upendra; Kumar, Neeraj; Singh, Bikram; Kaur, Satwinderjeet

doi:10.1016/j.bjp.2016.02.007

Cited by 9 publications

(8 citation statements)

References 69 publications

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“…Two flavanols isolated from leaves of Anthocephalus cadamba and 3 luteolin derivatives exhibited potent antioxidant and antigenotoxic activities in HeLa, COLO‐205 cancer cell lines, and human blood cells that were exposed to AFB1 (Chandel et al., ; Orhan et al., ). Proanthocyanidin was found to attenuate testicular reproductive damage and contribute to the maintenance of normal testicular morphology when male mice were exposed to ZEA, and such a protective effect likely resulted from the reduced oxidative damage by proanthocyanidin and the inhibition of testicular tissue apoptosis (Long et al., ).…”

Section: Food Compounds Especially Those Of Plant Origin For Prevenmentioning

confidence: 99%

“…In vivo animal experiments revealed that OTA-induced toxic effects were significantly reduced while the antioxidant enzymes were concomitantly enhanced in the male Sprague-Dawley rats cotreated with quercetin and/or chitosan nanoparticles (Abdel-Wahhab, Aljawish,El-Nekeety, Abdel-Aziem, & Hassan, 2017). Two flavanols isolated from leaves of Anthocephalus cadamba and 3 luteolin derivatives exhibited potent antioxidant and antigenotoxic activities in HeLa, COLO-205 cancer cell lines, and human blood cells that were exposed to AFB1 (Chandel et al, 2016;Orhan et al, 2016). Proanthocyanidin was found to attenuate testicular reproductive damage and contribute to the maintenance of normal testicular morphology when male mice were exposed to ZEA, and such a protective effect likely resulted from the reduced oxidative damage by proanthocyanidin and the inhibition of testicular tissue apoptosis (Long et al, 2017).…”

Section: Flavonoidsmentioning

confidence: 99%

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The Significance of Regulatory MicroRNAs: Their Roles in Toxicodynamics of Mycotoxins and in the Protection Offered by Dietary Therapeutics Against Mycotoxin‐Induced Toxicity

Xue

Sun‐Waterhouse

Wang

et al. 2018

Comp Rev Food Sci Food Safe

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Mycotoxins are contaminants commonly found in foods and represent a worldwide threat to human health and welfare. Efforts have been undertaken to reduce mycotoxins and their toxicity, including the introduction of good agricultural practices, appropriate food processing, specific biotransformation approaches, and pursue therapeutic agents to counteract mycotoxins. Efficient and predictive tools are required for investigations on mycotoxins and their toxicodynamics, and strategies for mycotoxin reduction. Gene expression and transcriptome analysis can unravel the mode of action, transformation and combined toxicity of mycotoxins, or mycotoxin's interactions with food components including dietary therapeutics, at the cellular level and from a molecular perspective. MicroRNAs (miRNAs) regulate endogenously and posttranscriptionally the expression of target genes and enzymes involved in physiological, disease and toxicological responses, and the metabolism of therapeutic agents. Accordingly, this review aimed to collect up‐to‐date information on (1) the regulatory role of miRNAs in mycotoxin‐initiated toxicological processes and (2) the protective role of active ingredients from plants on mycotoxin‐induced toxicity. Through such a review of published evidence, we found some common signal pathways involving miRNAs shared by these two types of biological events. This finding indicates the possibility of using miRNAs as biomarkers in assessing and controlling mycotoxins in food via cellular mechanisms.

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Section: Food Compounds Especially Those Of Plant Origin For Prevenmentioning

confidence: 99%

Section: Flavonoidsmentioning

confidence: 99%

The Significance of Regulatory MicroRNAs: Their Roles in Toxicodynamics of Mycotoxins and in the Protection Offered by Dietary Therapeutics Against Mycotoxin‐Induced Toxicity

Xue

Sun‐Waterhouse

Wang

et al. 2018

Comp Rev Food Sci Food Safe

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“…Several triterpenes, triterpene glycosides, irridoid glycosides, steroids and alkaloids have been isolated from this plant by various researchers all over the world. [11][12][13][14] Quinovic acid is an ursane type pentacyclic triterpenoid reported for its anticancer effects against breast and lung cancer cell lines. It induced the caspase 8 and 3 activation and PARP cleavage in MDA-MB-231 human breast cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Isolation, Cytotoxicity Evaluation, Docking, ADMET and Drug Likeness Studies of Secondary Metabolites from the Stem Bark of Anthocephalus cadamba (Roxb.)

et al. 2022

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Phytochemical investigation of the stem bark of Anthocephalus cadamba(Rubiaceae) led to the isolation of total ten secondary metabolites (1‐10) including β–sitosterol (1), ursolic acid (2), vanillic acid (3), quinovic acid (4), 3‐O‐[α‐L‐rhamnopyranosyl]‐quinovic acid (5), β‐sitosterol β‐D‐glucoside (6), cadambine (7), 3β‐dihydrocadambine (8), 7‐O‐acetyl loganin (9) and hexyl p‐coumarate (10). Four acetylated derivatives 2 a,5 a,7 aand8 aobtained through acetylation of compounds 2, 5, 7 and 8 respectively. All the compounds characterized using 1H and 13CNMR, HRESIMS and IR and comparison with literature. Compound 4showed the best cytotoxic activity with IC50 value 4 and 7 μM against pancreatic (MIA‐pa‐Ca‐2) and leukemia (HL‐60) cancer cells respectively. Docking results supported the anticancer potential of compound 4via inhibition of EGFR receptor (PDB ID:3POZ) and its pharmacokinetic profile found optimized as per the Lipinski's filter. Therefore compound 4has the potential to be developed as an anticancer agent against pancreatic cancer cells.

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“…Leaves are used as woody forage to feed livestock 5 and have effects of antibacterial and anti-inflammatory to animals 6 . One particular value is that the species has enormous pharmacological implications due to its rich secondary metabolites (e.g., phenols and alkaloids) 6 – 9 . The monoterpenoids, alkaloids and triterpenoids are potentially used for medicinal purposes 10 , 11 .…”

Section: Introductionmentioning

confidence: 99%

A complete sequence of mitochondrial genome of Neolamarckia cadamba and its use for systematic analysis

Wang

Chen

et al. 2021

Sci Rep

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Neolamarckia cadamba is an important tropical and subtropical tree for timber industry in southern China and is also a medicinal plant because of the secondary product cadambine. N. cadamba belongs to Rubiaceae family and its taxonomic relationships with other species are not fully evaluated based on genome sequences. Here, we report the complete sequences of mitochondrial genome of N. cadamba, which is 414,980 bp in length and successfully assembled in two genome circles (109,836 bp and 305,144 bp). The mtDNA harbors 83 genes in total, including 40 protein-coding genes (PCGs), 31 transfer RNA genes, 6 ribosomal RNA genes, and 6 other genes. The base composition of the whole genome is estimated as 27.26% for base A, 22.63% for C, 22.53% for G, and 27.56% for T, with the A + T content of 54.82% (54.45% in the small circle and 54.79% in the large circle). Repetitive sequences account for ~ 0.14% of the whole genome. A maximum likelihood (ML) tree based on DNA sequences of 24 PCGs supports that N. cadamba belongs to order Gentianales. A ML tree based on rps3 gene of 60 species in family Rubiaceae shows that N. cadamba is more related to Cephalanthus accidentalis and Hymenodictyon parvifolium and belongs to the Cinchonoideae subfamily. The result indicates that N. cadamba is genetically distant from the species and genera of Rubiaceae in systematic position. As the first sequence of mitochondrial genome of N. cadamba, it will provide a useful resource to investigate genetic variation and develop molecular markers for genetic breeding in the future.

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Isolation and characterization of flavanols from Anthocephalus cadamba and evaluation of their antioxidant, antigenotoxic, cytotoxic and COX-2 inhibitory activities

Cited by 9 publications

References 69 publications

The Significance of Regulatory MicroRNAs: Their Roles in Toxicodynamics of Mycotoxins and in the Protection Offered by Dietary Therapeutics Against Mycotoxin‐Induced Toxicity

The Significance of Regulatory MicroRNAs: Their Roles in Toxicodynamics of Mycotoxins and in the Protection Offered by Dietary Therapeutics Against Mycotoxin‐Induced Toxicity

Isolation, Cytotoxicity Evaluation, Docking, ADMET and Drug Likeness Studies of Secondary Metabolites from the Stem Bark of Anthocephalus cadamba (Roxb.)

A complete sequence of mitochondrial genome of Neolamarckia cadamba and its use for systematic analysis

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