In vivo diabetic wound healing effect and HPLC–DAD–ESI–MS/MS profiling of the methanol extracts of eight Aloe species

Sayed, Abeer M. El; Ezzat, Shahira M.; Naggar, Moataz M. El; El‐Hawary, Seham S.

doi:10.1016/j.bjp.2016.01.009

Cited by 71 publications

(62 citation statements)

References 44 publications

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“…Unambiguous plant identification is of primary concern to guarantee quality, safety, and efficacy of a drug or an extract. In a previous study, we had shown that 6′-malonylnataloin, aloe-emodin-8-O-glucoside, and flavone-6,8-di-C-glucosides could be considered as chemotaxonomic markers for the investigated eight Aloe species [18]. Moreover, our present study clearly indicated that RAPD markers could be used effectively to authenticate our eight Aloe species in the local herbal markets.…”

Section: Original Paperssupporting

confidence: 49%

“…For this reason, the accurate identification of these species is an urgent need in the herbal industry to maintain the efficacy and quality of herbal formulations. The chemical composition of the eight species of Aloe has been studied by the authors [18] using an LC-MS/MS technique. Our major objective, therefore, was to develop the DNA-based marker "RAPD" for the accurate identification of the eight Aloe species.…”

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confidence: 99%

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Use of Random Amplified Polymorphic DNA (RAPD) Technique to Study the Genetic Diversity of Eight Aloe Species

2016

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The genus comprises over 400 species of flowering succulent plants. leaves are used in the treatment of asthma, gastrointestinal ulcers, cardiovascular disease, tumors, burns, and diabetes. They are rich in anthraquinones, such as aloin, aloe-emodin, chrysophanol, aloinoside A, and aloinoside B. The various species of show chemical and morphological similarity and diversity, which depend on the genotype and environmental conditions. In a continuity to our interest in the genus, this study targets the authentication of eight different species, (A) (A) (A) (A) (A), (A) (A), and (A), grown in Egypt by using the technique of random amplified polymorphic DNA. Twelve decamer primers were screened in amplification with genomic DNA extracted from all species, of which five primers yielded species-specific reproducible bands. Out of 156 loci detected, the polymorphic, monomorphic, and unique loci were 107, 26, and 23, respectively. Based on a dendrogram and similarity matrix, the eight species were differentiated from each other and showed more divergence. species prevailed similarity coefficients of 54-70 % by which they could be classified into three major groups. Thus, this technique may contribute to the identification of these species that have great morphological similarity in the Egyptian local markets.

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Section: Original Paperssupporting

confidence: 49%

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confidence: 99%

Use of Random Amplified Polymorphic DNA (RAPD) Technique to Study the Genetic Diversity of Eight Aloe Species

2016

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“…Lidah buaya mengandung metabolit sekunder seperti antrakuinon, tanin, saponin, terpenoid, steroid (Kommoun et.al, 2011) fenolik dan flavonoid (El Sayed et al, 2016). Lidah buaya memiliki aktivitas antibakteri dan terbukti dapat menghambat pertumbuhan Staphylococcus aureus (S.aureus) (He et al, 2011).…”

Section: Pendahuluanunclassified

“…Fenol dan flavonoid juga diketahui memiliki aktivitas antibakteri dengan cara merusak permeabilitas dinding sel bakteri (Sharita et al,2015). Senyawa fenolik yang terkandung dalam lidah buaya meliputi coumaric acid derivates, malonyl-3,4-O-dicaffeoylquinic acid, caffeoyl quinic acid hexoside, 3-O-caffeoyl-5 Sayed et al, 2016).…”

Section: Tabel II Diameter Zona Hambat Mic Gentamisin Sulfat Terhadaunclassified

Determination of FICI of Ethanolic Extract of Aloe Vera Skin Leaves (Aloe vera (L.) Burm.f.) and Gentamicin Sulphate againts Staphylococcus aureus

2017

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“…[156][157][158][159][160][161][162] Emodin also plays an active role in treating diabetic nephropathy and neuropathy at earlier stages. However, due to the high first pass metabolism and greater hydrophobicity of emodin, it cannot be efficiently delivered through oral means, limiting the bioavailability and bioaccessibility of the compound.…”

Section: Nano-emodinmentioning

confidence: 99%

Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus – current status

Ganesan¹,

Arulselvan²,

Choi³

2017

IJN

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Type 2 diabetes mellitus (T2DM) is a major chronic disease that is prevalent worldwide, and it is characterized by an increase in blood glucose, disturbances in the metabolism, and alteration in insulin secretion. Nowadays, food-based therapy has become an important treatment mode for type 2 diabetes, and phytobioactive compounds have gained an increasing amount of attention to this end because they have an effect on multiple biological functions, including the sustained secretion of insulin and regeneration of pancreatic islets cells. However, the poor solubility and lower permeability of these phyto products results in a loss of bioactivity during processing and oral delivery, leading to a significant reduction in the bioavailability of phytobioactive compounds to treat T2DM. Recently, nanotechnological systems have been developed for use as various types of carrier systems to improve the delivery of bioactive compounds and thus obtain a greater bioavailability. Furthermore, carrier systems in most nanodelivery systems are highly biocompatible, with nonimmunologic behavior, a high degree of biodegradability, and greater mucoadhesive strength. Therefore, this review focuses on the various types of nanodelivery systems that can be used for phytobioactive compounds in treating T2DM with greater antidiabetic effects. There is also additional focus on improving the effects of various phytobioactive compounds through nanotechnological delivery to ensure a highly efficient treatment of type 2 diabetes.

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In vivo diabetic wound healing effect and HPLC–DAD–ESI–MS/MS profiling of the methanol extracts of eight Aloe species

Cited by 71 publications

References 44 publications

Use of Random Amplified Polymorphic DNA (RAPD) Technique to Study the Genetic Diversity of Eight Aloe Species

Use of Random Amplified Polymorphic DNA (RAPD) Technique to Study the Genetic Diversity of Eight Aloe Species

Determination of FICI of Ethanolic Extract of Aloe Vera Skin Leaves (Aloe vera (L.) Burm.f.) and Gentamicin Sulphate againts Staphylococcus aureus

Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus – current status

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In vivo diabetic wound healing effect and HPLC–DAD–ESI–MS/MS profiling of the methanol extracts of eight Aloe species

Cited by 71 publications

References 44 publications

Use of Random Amplified Polymorphic DNA (RAPD) Technique to Study the Genetic Diversity of Eight Aloe Species

Use of Random Amplified Polymorphic DNA (RAPD) Technique to Study the Genetic Diversity of Eight Aloe Species

Determination of FICI of Ethanolic Extract of Aloe Vera Skin Leaves (Aloe vera (L.) Burm.f.) and Gentamicin Sulphate againts Staphylococcus aureus

Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus &ndash; current status

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Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus – current status