Determination of the regulatory properties of Yucca schidigera extracts on the biochemical parameters and plasma hormone levels associated with obesity

Küçükkurt, İ̇smail; Akkol, Esra Küpeli; Karabağ, Funda; İnce, Sinan; Süntar, İpek; Eryavuz, Abdullah; Sözbilir, Nalan Bayşu

doi:10.1016/j.bjp.2015.12.005

Cited by 17 publications

(7 citation statements)

References 29 publications

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“…In the current study, we found that Ce6-PDT treatment on HC2.5Hi groups resulted in a remarkable decrease in leptin levels by 16.5%, respectively, and an increase in adiponectin levels by 10.2%, respectively, when compared to HFD-fed mice. Moreover, the studies have revealed that the reduction in VLDL, LDL, triglycerides, and total cholesterol, as well as an increase in HDL levels, are directly associated with anti-obesity effects and cardiovascular diseases [ 46 ]. In this regard, our result shows a significant reduction in LDL and total cholesterol that had been increased by HFD in the HC2.5Hi, HC5Lo, and HC5Hi groups, respectively.…”

Section: Discussionmentioning

confidence: 99%

Anti-Obesity Effect of Chlorin e6-Mediated Photodynamic Therapy on Mice with High-Fat-Diet-Induced Obesity

et al. 2023

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This study aimed to evaluate the efficacy of Chlorin e6 (Ce6)-based photodynamic therapy (PDT) for anti-obesity activities in high-fat-diet (HFD)-induced obesity mouse models. We induced obesity in C57BL/6 mice by HFD and administered Ce6 (2.5 or 5 mg/kg) orally with 3 h of incubation. The mice were then exposed to light of high fluence rate (4.96 mW/cm2) or low fluence rate (2.56 mW/cm2) in the designed LED mouse chamber 2–3 days a week for up to 8 weeks. The study also analyzed the pharmacokinetics and optimization of the drug by evaluating the absorption, distribution, metabolism, and excretion (ADME) of Ce6 in the rat models. Both low doses (2.5 mg/kg) and high doses (5 mg/kg) of Ce6 with high irradiation dose showed better anti-obesity effects than other groups with decreased body weight. The lipid accumulation in the liver and adipocyte size in epididymal adipose tissues were found to be decreased by Ce6-PDT in comparison to vehicle-treated HFD groups. We also observed increased levels of the lipidomic biomarkers, such as leptin and LDL cholesterol, while observing decreasing levels of total cholesterol and adiponectin in the Ce6-PDT-treated mice. These findings may provide valuable insight into Ce6-PDT as an alternative and non-invasive therapeutic methodology for obesity and obesity-related diseases.

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Section: Discussionmentioning

confidence: 99%

Anti-Obesity Effect of Chlorin e6-Mediated Photodynamic Therapy on Mice with High-Fat-Diet-Induced Obesity

et al. 2023

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“…Yucca schidigera from Asparagaceae is an herb mainly for ornamental and urban greening. It is native to deserts of the southwestern United States and northern Mexico, and occasionally planted in China (Kucukkurt et al, 2016). For indigenous peoples, this succulent flowering plant has various folk remedies associated with it that can contribute to relieving joint pain, treating skin ulcers, and stopping diarrhea or bleeding (Patel, 2012).…”

Section: Introductionmentioning

confidence: 99%

Yucca schidigera extract decreases nitrogen emission via improving nutrient utilisation and gut barrier function in weaned piglets

Fan

Xiao

Chen

et al. 2021

Animal Physiology Nutrition

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Yucca schidigera extract (YE) can decrease ammonia concentration in livestock housing, which could be associated with the inhibition of urease. The aim of this study was to investigate the other possible reasons of dietary YE supplementation reducing nitrogen emission in weaned piglets. A total of 14 crossbred weaned barrows were allotted into two groups fed the diets supplementing 0 and 120 mg/kg YE for 14 days. The YE administration decreased F/G ratio and hindgut NH3‐N production in weaned piglets (p < 0.05). Dietary YE supplementation decreased serum urea nitrogen levels, and increased nutrient digestibility, which could be related to the improvement of morphology, digestive and absorptive enzyme activities, and nutrient transporter mRNA expression in jejunal mucosa of weaned piglets (p < 0.05). The mRNA expression of tight junction proteins, mucins and apoptosis‐related genes was also improved by YE treatment in jejunal mucosa of weaned piglets (p < 0.05). In addition, dietary YE supplementation regulated the microbiota structure and volatile fatty acid content in distal intestine of weaned piglets (p < 0.05). These results suggest that YE administration can decrease hindgut NH3–N production in weaned piglets, which is associated with the increased nutrient utilization and gut‐barrier function.

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“…Several studies on the effect of saponins on leptin have been documented[ 32 ]. While some recorded increase in serum leptin concentration with saponin administration[ 31 , 33 ], others documented decrease in serum leptin concentration following saponin administration[ 34 , 35 ].…”

Section: Adipokines In Insulin Resistancementioning

confidence: 99%

Saponins as adipokines modulator: A possible therapeutic intervention for type 2 diabetes

Elekofehinti¹,

Ejelonu²,

Kamdem³

et al. 2017

WJD

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Development of type 2 diabetes has been linked to β-cell failure coupled with insulin resistance and obesity. Adipose tissue, known as the fat store, secretes a number of hormones and proteins collectively termed adipokines some of which regulate insulin sensitivity. Dysregulation in the secretion of adipokines has been linked to insulin resistance and type 2 diabetes. In this review, we summarized evidence of the role of adipokines with focus on leptin, adiponectin, adipsin, visfatin and apelin in the pathogenesis of type 2 diabetes and discussed the potential of saponins to modify the ill-regulated adipokines secretions, which could promote the use of this class of phytochemicals as potential antidiabetics agents.

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Determination of the regulatory properties of Yucca schidigera extracts on the biochemical parameters and plasma hormone levels associated with obesity

Cited by 17 publications

References 29 publications

Anti-Obesity Effect of Chlorin e6-Mediated Photodynamic Therapy on Mice with High-Fat-Diet-Induced Obesity

Anti-Obesity Effect of Chlorin e6-Mediated Photodynamic Therapy on Mice with High-Fat-Diet-Induced Obesity

Yucca schidigera extract decreases nitrogen emission via improving nutrient utilisation and gut barrier function in weaned piglets

Saponins as adipokines modulator: A possible therapeutic intervention for type 2 diabetes

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