Antileishmanial metabolites from Lantana balansae

Maldonado, Eliana M.; Salamanca, Efraín; Giménez, Alberto; Sterner, Olov

doi:10.1016/j.bjp.2015.11.007

Cited by 11 publications

(10 citation statements)

References 26 publications

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“…Four known compounds were identified by high-performance liquid chromatography (HPLC)-atmospheric pressure chemical ionization (APCI)mass spectrometry (MS) and nuclear magnetic resonance (NMR) analysis of the ethyl acetate fraction. Compounds 1 and 2 were identified as 3′-demethoxysudachitin and salvigenin, and 2 compounds isolated and recrystallized from n-hexane-ethyl acetate were identified as the polymethoxylated flavones pebrellin (3) and xanthomicrol (4). Spectroscopic data are consistent with those previously reported (Figures S2-S5).…”

supporting

confidence: 87%

“…2 A variety of phytochemicals with significant bioactivities have been discovered in this genus, including flavonoids, coumarins, sesquiterpene lactones, and some germacrene derivatives. 3,4 From a pharmacological point of view, the antibacterial activity against Mycobacterium tuberculosis H37Rv of organic extracts (hexane, chloroform, ethyl acetate, and methanol) of T. angustifolia aerial parts has been described. 5 In traditional Mexican medicine, the aerial parts of T. angustifolia have been used as a water-extract formulation to reduce blood glucose in alloxan-induced diabetic mice.…”

mentioning

confidence: 99%

“…As different compounds isolated from Trixis species have shown biological activities, 4 we fractionated TxAE by liquid-liquid partition with ethyl acetate to improve the identification and purification of compounds probably involved in the TxAE hypolipidemic effects. Four known compounds were identified by high-performance liquid chromatography (HPLC)-atmospheric pressure chemical ionization (APCI)mass spectrometry (MS) and nuclear magnetic resonance (NMR) analysis of the ethyl acetate fraction.…”

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confidence: 99%

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Hypolipidemic Effect ofTrixis angustifoliaAqueous Extract on Triton WR-1339- and High-Fat Diet-Induced Hyperlipidemic Mice

Salazar-Gómez

Sánchez‐Chávez

Zepeda

et al. 2019

Natural Product Communications

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The aim of the present study was to evaluate the hypolipidemic effect of Trixis angustifolia aqueous extract (TxAE) on Triton WR-1339- and high-fat diet-induced hyperlipidemic mice. In the Triton model, treatment with TxAE at 100 and 200 mg/kg body weight produced a significant decrease in triglycerides and very low-density lipoprotein levels and a significant increase in high-density lipoprotein (HDL). Similarly, administration of TxAE along with the high-fat diet induced a significant decrease in serum total cholesterol, low-density lipoproteins, and increase in HDL. In addition, a phytochemical study of TxAE led to the isolation of 2 previously described compounds: pebrellin and xanthomicrol. This is the first time that these compounds have been identified in a plant extract with hypolipidemic effect. The results suggest the possible therapeutic potential of TxAE as a hypolipidemic agent supporting the usage of T. angustifolia as a traditional medicine.

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confidence: 87%

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confidence: 99%

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confidence: 99%

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Hypolipidemic Effect ofTrixis angustifoliaAqueous Extract on Triton WR-1339- and High-Fat Diet-Induced Hyperlipidemic Mice

Salazar-Gómez

Sánchez‐Chávez

Zepeda

et al. 2019

Natural Product Communications

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“…proved that the compound was (9 S ,13 R )-12-OPDA, i.e., (+)- trans -12-OPDA [40]. Except for the activity as a plant hormone, 12-OPDA exerted cytoprotective effects in human neuroblastoma SH-SY5Y cells subjected to oxidative stress [41], mitigated LPS-induced inflammation in microglia [42], inhibited proliferation of human breast cancer cells [43], and demonstrated antileishmanial activity [44]. Thus, we decided to check whether or not the compound may contribute to the overall activity of C. divaricatum .…”

Section: Discussionmentioning

confidence: 99%

Carpesium divaricatum Sieb. & Zucc. Revisited: Newly Identified Constituents from Aerial Parts of the Plant and Their Possible Contribution to the Biological Activity of the Plant

et al. 2019

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Carpesium divaricatum Sieb. & Zucc. has a long history of use as both a medicinal and a food plant. However, except for terpenoids, its chemical constituents have remained poorly investigated. The composition of hydroalcoholic extract from aerial parts of C. divaricatum was analyzed by HPLC-DAD-MSn, revealing the presence of numerous caffeic acid derivatives that were formerly unknown constituents of the plant. In all, 17 compounds, including commonly found chlorogenic acids and rarely occurring butyryl and methylbutyryl tricaffeoylhexaric acids, were tentatively identified. Fractionation of lipophilic extract from cultivated shoots led to the isolation of 12-oxo-phytodienoic acid (12-OPDA), which is a newly identified constituent of the plant. The compound, at concentrations of 0.5, 1.0, and 2.5 μM, significantly reduced IL-8, IL-1β, TNFα, and CCL2 excretion by lipopolysaccharide (LPS)-stimulated human neutrophils. Reactive oxygen species (ROS) production induced by f-MLP was also significantly diminished in the neutrophils pretreated by 12-OPDA. The newly identified constituents of the plant seem to be partly responsible for its pharmacological activity and elevate the value of C. divaricatum as a potential functional food.

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“…A flavonoid in Artemisia argyi and Eupatorium lindleyanum [1][2][3][4], jaceosidin, also was discovered in Paronychia argentea Lam and antileishmanial metabolites from Lantana balansae [5,6]. Jaceosidin had a good anti-inflammatory effect [7][8][9][10] and played a role in immune suppression.…”

Section: Introductionmentioning

confidence: 99%

Determination and pharmacokinetic study of jaceosidin in rat plasma by UPLC–MS/MS

Zhou

Chen

et al. 2018

Acta Chromatographica

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In this work, a sensitive and selective ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and fully validated for determination of jaceosidin in rat plasma. Avicularin was used as the internal standard (IS), and protein precipitation by acetonitrile was used to prepare samples. Chromatographic separation was achieved on a UPLC BEH C18 column (2.1 mm × 100 mm, 1.7 μm) with 0.1% formic acid and acetonitrile as the mobile phase with gradient elution. An electrospray ionization (ESI) source was applied and operated in positive ion mode; multiple reaction monitoring (MRM) mode was used for quantification. Calibration plots were linear throughout the range 2-500 ng mL −1 for jaceosidin in rat plasma. Relative standard deviation (RSD) of intra-day and inter-day precision was less than 12%. The accuracy of the method was between 88.7% and 109.7%. Mean recoveries of jaceosidin in rat plasma ranged from 65.4% to 77.9%. The developed UPLC-MS/MS method was successfully applied to pharmacokinetic study of jaceosidin after intravenous administration of 2 mg kg −1 in rats. We could find that the jaceosidin rapidly eliminated, the t 1/2 was 0.7 ± 0.3 h, and clearance (CL) was 22.4 ± 3.0 L h −1 kg −1 .

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Antileishmanial metabolites from Lantana balansae

Cited by 11 publications

References 26 publications

Hypolipidemic Effect ofTrixis angustifoliaAqueous Extract on Triton WR-1339- and High-Fat Diet-Induced Hyperlipidemic Mice

Hypolipidemic Effect ofTrixis angustifoliaAqueous Extract on Triton WR-1339- and High-Fat Diet-Induced Hyperlipidemic Mice

Carpesium divaricatum Sieb. & Zucc. Revisited: Newly Identified Constituents from Aerial Parts of the Plant and Their Possible Contribution to the Biological Activity of the Plant

Determination and pharmacokinetic study of jaceosidin in rat plasma by UPLC–MS/MS

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