Hypolipidemic and antiatherogenic effects of Cynara scolymus in cholesterol-fed rats

Mocelin, Ricieri; Marcon, Matheus; Santo, Glaucia Dal; Zanatta, Leïla; Sachett, Adrieli; Schönell, Amanda P.; Bevilaqua, Fernanda; Giachini, Marta; Chitolina, Rafael; Wildner, Silvana M.; Conterato, Greicy M. M.; Piato, Ângelo; Gomes, Denise B.; Junior, Walter Antônio Roman

doi:10.1016/j.bjp.2015.11.004

Cited by 31 publications

(14 citation statements)

References 49 publications

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“…Aqueous methanolic extracts of green globe and violet artichoke leaves and heads supplementation led to increase of GPx level in liver, heart, and blood and to decrease of MDA level in liver, heart, and blood in hypercholesterolemic rats (Magied, Hussien, Zaki, & Said, ). In addition, another study reported that administration of aqueous extract of artichoke leaf to hypercholesterolemic rats resulted in a significant decrease of ox‐LDL and antioxidized‐LDL level (Mocelin et al, ). However, Kucukgergin et al () showed that artichoke leaf extract decreased MDA and DC level in liver and heart and increased GPx, GST, and vitamin E in liver but did not change SOD, GSH, and vitamin C in liver and heart of hypercholesterolemic rats.…”

Section: Resultsmentioning

confidence: 99%

The antioxidant activity of artichoke (Cynara scolymus): A systematic review and meta‐analysis of animal studies

Salekzamani

Ebrahimi-Mameghani

Rezazadeh

2018

Phytotherapy Research

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Current evidence has shown antioxidant activity of artichoke as a potent source of antioxidant compounds. However, it seems that the antioxidant activity of artichokehas not yet been reviewed. Therefore, the present study was designed to perform a systematic review of human studies, animal models, and in vitro systems and to conduct a meta-analysis of animal studies on the antioxidant effects of artichoke. We searched four electronic databases till April 2018 using relevant keywords. All English language articles were assessed. For animal studies, standardized mean difference was pooled using a random effects model. The included studies were evaluated for eligibility and risk of bias. Thirty-nine articles (two human, 23 animal, and 14 in vitro studies) were reviewed. The results of in vitro systems supported the antioxidant effect of artichoke, whereas limited clinical trials indicated no change or a slight improvement of antioxidant status. Finding of animal studies indicated that artichoke extract supplementation increased superoxide dismutase, catalase, glutathione, and glutathione peroxidase level in liver, as well as, decreased malondialdehyde level in liver and plasma of animals with induced disease significantly compared with comparison group. This meta-analysis provided convincing evidence for antioxidant activity of artichoke in animals.

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Section: Resultsmentioning

confidence: 99%

The antioxidant activity of artichoke (Cynara scolymus): A systematic review and meta‐analysis of animal studies

Salekzamani

Ebrahimi-Mameghani

Rezazadeh

2018

Phytotherapy Research

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“…Cynara cardunculus L. is known for its antiatherogenic and hypolipidemic effects. Hypercholesterolemic rats were fed with C. cardunculus leaves aqueous extract at the amount of 150, 300, and 60 mg/kg (Mocelin et al, 2016). The extracts exhibited DPPH scavenging activity with an IC 50 value of 57.40 ± 2.05 µg/ mL.…”

Section: In Vitromentioning

confidence: 99%

A Review on the Potential Use of Medicinal Plants From Asteraceae and Lamiaceae Plant Family in Cardiovascular Diseases

2020

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Cardiovascular diseases are one of the most prevalent diseases worldwide, and its rate of mortality is rising annually. In accordance with the current condition, studies on medicinal plants upon their activity on cardiovascular diseases are often being encouraged to be used in cardiovascular disease management, due to the availability of medicinal values in certain dedicated plants. This review was conducted based on two plant families, which are Asteraceae and Lamiaceae, to study on their action in cardiovascular disease relieving activities, to review the relationship between the phytochemistry of Asteraceae and Lamiaceae families and their effect on cardiovascular diseases, and to study their toxicology. The medicinal plants from these plant family groups are collected based on their effects on the mechanisms that affect the cardiovascular-related disease which are an antioxidant activity, anti-hyperlipidemic or hypocholesterolemia, vasorelaxant effect, antithrombotic action, and diuresis effect. In reference to various studies, the journals that conducted in vivo or in vitro experiments, which were used to prove the specific mechanisms, are included in this review. This is to ensure that the scientific value and the phytochemicals of the involved plants can be seen based on their activity. As a result, various plant species from both Asteraceae and Lamiaceae plant family have been identified and collected based on their study that has proven their effectiveness and uses in cardiovascular diseases. Most of the plants have an antioxidant effect, followed by anti-hyperlipidemia, vasorelaxant, antithrombotic, and diuretic effect from the most available to least available studies, respectively. These are the mechanisms that contribute to various cardiovascular diseases, such as heart attack, stroke, coronary heart disease, and hypertension. Further studies can be conducted on these plant species by identifying their ability and capability to be developed into a new drug or to be used as a medicinal plant in treating various cardiovascular diseases.

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“…Several studies employing experimental models have described various beneficial effects of artichoke [[15], [16], [17]], but such findings cannot be straightforwardly transferred over to larger epidemiological settings. Therefore, the potential effects of artichoke consumption on lipid profile should be further investigated before it can be identified as a useful nutraceutical compound for that purpose.…”

Section: Introductionmentioning

confidence: 99%

The effect of artichoke on lipid profile: A review of possible mechanisms of action

Santos

Bueno

Mota

2018

Pharmacological Research

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Cardiovascular disease is a highly prevalent issue worldwide, and one of its main manifestations, dyslipidaemia, needs more attention. Cooked artichoke (Cynara scolymus) hearts or artichoke leaf extract (ALE) are believed to be helpful in the treatment of dyslipidaemia. In this narrative review, we provide a brief overview of the potential impact of artichoke consumption on lipid profile. We appraised the Cochrane, MEDLINE and Web of Science databases, and included articles published between 2000 and June 2018 on intervention in humans only. The main potential of ALE administration observed on lipid profile relates to decreased serum LDL, total cholesterol and triglyceride concentrations, although no strong evidence for increasing HDL appears to exist. Evidence suggests that decreases of 8-49 mg/dL for LDL concentration, 12-55 mg/dL for total cholesterol, and 11-51 mg/dL for triglycerides, can be attributed to 2 to 3 g/d of ALE, in which its components luteolin and chlorogenic acid may play a key role. On the other hand, the effects of cooked artichoke hearts can be attributed mainly to its soluble fibres, particularly inulin. Despite the convincing evidence on its health benefits, additional long-term clinical trials are pivotal to fully elucidate the potential effects of ALE administration on positive cardiovascular outcomes.

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Hypolipidemic and antiatherogenic effects of Cynara scolymus in cholesterol-fed rats

Cited by 31 publications

References 49 publications

The antioxidant activity of artichoke (Cynara scolymus): A systematic review and meta‐analysis of animal studies

The antioxidant activity of artichoke (Cynara scolymus): A systematic review and meta‐analysis of animal studies

A Review on the Potential Use of Medicinal Plants From Asteraceae and Lamiaceae Plant Family in Cardiovascular Diseases

The effect of artichoke on lipid profile: A review of possible mechanisms of action

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