Analgesic and anti-inflammatory activities of hydro-alcoholic extract of Lavandula officinalis in mice: possible involvement of the cyclooxygenase type 1 and 2 enzymes

Husseini, Yasaman; Sahraei, Hedayat; Meftahi, Gholam Hossein; Dargahian, M.; Mohammadi, Alireza; Hatef, Boshra; Zardooz, Homeira; Ranjbaran, Mina; Hosseini, Seydeh Bentolhuda; Ali-Beig, Hengameh; Behzadnia, Mohammad Javad; Majd, Ahmad; Bahari, Zahra; Ghoshooni, Hassan; Jalili, Cyrus; Golmanesh, Leila

doi:10.1016/j.bjp.2015.10.003

Cited by 27 publications

(17 citation statements)

References 16 publications

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“…Stress has been shown to activate the inflammatory cascade, that IL-6 as circulating biomarkers of inflammation plays a role in both acute and chronic stress responses, which stress can induce profound elevates in circulating IL-6 33,34 . Some studies showed that nerve injury increased the inflammation factor in the central nervous system [35][36][37][38][39] . The role of inflammatory mediators in gonadal abnormal function investigated in studies [9][10][11] , which in line with our results.…”

Section: Discussionmentioning

confidence: 99%

Effect of Intermittent Feeding on Gonadal Function in Male And Female NMRI Mice During Chronic Stress

Ehteram

Sahraei

Meftahi

et al. 2017

Braz. arch. biol. technol.

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Section: Discussionmentioning

confidence: 99%

Effect of Intermittent Feeding on Gonadal Function in Male And Female NMRI Mice During Chronic Stress

Ehteram

Sahraei

Meftahi

et al. 2017

Braz. arch. biol. technol.

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“…The extracts were collected and filtered by Whatman filter papers. The yielded extracts were concentrated under vacuum and kept in a dark bottle in a refrigerator at 4 °C until use [13].…”

Section: Plant Essential Oil and Extract Preparationmentioning

confidence: 99%

Chemical Composition, Antibacterial and Analgesic Activity of Lavandula stoechas Flowers from North of Iran

Khavarpour

Vahdat

Kazemi

et al. 2019

IJE

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Aromatic plants have subscribed to the belief that they can be used in food, perfumery, pharmaceutical and cosmetic products due to their nutritional and biological properties. The present study was designed to examine the chemical composition and antibacterial and analgesic properties of Lavandula stoechas flowers originating Amol, north of Iran for the first time. The essential oil of Lavandula stoechas flowers was obtained by hydrodistillation. Gas chromatography-mass spectrometry examination was used for its analysis. Staphylococcus aureus, Escherichia coli, Salmonella enteritidis and Bacillus subtilis were utilized to evaluate the antibacterial activity of essential oil using agar disk diffusion and microdilution assayes. GC-MS analysis revealed Linalol (35.69%) Borneol (14.99%) and 1,8-Cineole (11.45%) as the main compounds of the oil. Antibacterial assayes of various dilutions of essential oil revealed its remarkable antibacterial activity against gram-positive Staphylococcus aureus. Furthermore, the water and ethanolic extracts inhibited the pain resulting from hot-plate test. The results proposed lavandula stoechas from Amol as an alternative natural bioactive compound which posses antibacterial and analgesic effects to use in pharmaceutical industries.

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“…It has been demonstrated that L-NAME by itself does not significantly alter the baseline concentrations of DA, but it may inhibit DA release much more in amphetamine-dependent rats. Additionally, L-arginine induces DA release from the striatum in vivo and L-NNA (an inhibitor of NO synthesis) markedly reduces the effect of L-arginine on DA release (Hosseini et al, 2016; Gholami et al, 2003; Karami et al, 2003; Sahraei et al, 2007). …”

Section: Role Of Nitric Oxide In Dopamine Release In the Ventral Tmentioning

confidence: 99%

Review Paper: Role of Nitric Oxide on Dopamine Release and Morphine-Dependency

Motahari

Sahraei

Meftahi

2016

BCN

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The catastrophic effects of opioids use on public health and the economy are documented clearly in numerous studies. Repeated morphine administration can lead to either a decrease (tolerance) or an increase (sensitization) in its behavioral and rewarding effects. Morphine-induced sensitization is a major problem and plays an important role in abuse of the opioid drugs. Studies reported that morphine may exert its effects by the release of nitric oxide (NO). NO is a potent neuromodulator, which is produced by nitric oxide synthase (NOS). However, the exact role of NO in the opioid-induced sensitization is unknown. In this study, we reviewed the role of NO on opioid-induced sensitization in 2 important, rewarding regions of the brain: nucleus accumbens and ventral tegmentum. In addition, we focused on the contribution of NO on opioid-induced sensitization in the limbic system.

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Analgesic and anti-inflammatory activities of hydro-alcoholic extract of Lavandula officinalis in mice: possible involvement of the cyclooxygenase type 1 and 2 enzymes

Cited by 27 publications

References 16 publications

Effect of Intermittent Feeding on Gonadal Function in Male And Female NMRI Mice During Chronic Stress

Effect of Intermittent Feeding on Gonadal Function in Male And Female NMRI Mice During Chronic Stress

Chemical Composition, Antibacterial and Analgesic Activity of Lavandula stoechas Flowers from North of Iran

Review Paper: Role of Nitric Oxide on Dopamine Release and Morphine-Dependency

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