2015
DOI: 10.1016/j.bjp.2015.09.003
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Evaluation of acetylcholinesterase inhibitory activity of Brazilian red macroalgae organic extracts

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Cited by 40 publications
(14 citation statements)
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“…Thus, there is an urge to find safer AChE inhibitors from natural sources. 49,51 In this study, the methanolic extract obtained using homogenization (HAE-methanol) was the most potent inhibitor of AChE and BChE (Table 3).…”
Section: Enzyme Inhibitory Propertiesmentioning
confidence: 79%
See 1 more Smart Citation
“…Thus, there is an urge to find safer AChE inhibitors from natural sources. 49,51 In this study, the methanolic extract obtained using homogenization (HAE-methanol) was the most potent inhibitor of AChE and BChE (Table 3).…”
Section: Enzyme Inhibitory Propertiesmentioning
confidence: 79%
“…However, these drugs have showed limited efficacy and unfavorable effects such as gastrointestinal disturbances and hepatotoxicity. Thus, there is an urge to find safer AChE inhibitors from natural sources . In this study, the methanolic extract obtained using homogenization (HAE–methanol) was the most potent inhibitor of AChE and BChE (Table ).…”
Section: Resultsmentioning
confidence: 99%
“…AChE is localized in synaptic gaps of the central and peripheral nervous system and is responsible for the breakdown of acetylcholine (ACh). Thus, AChE terminates nerve impulses through the loss of basal forebrain cholinergic neurons and by reducing the level of the neurotransmitter ACh, which is characteristic of AD as a chronic neurodegenerative disorder [ 29 , 30 ]. Inhibition of AChE increases cholinergic functions, and hence, it is the therapeutic target for not only managing AD, but also for moderating other disorders such as myasthenia gravis, glaucoma, and Lewy body dementia [ 30 ].…”
Section: Resultsmentioning
confidence: 99%
“…DCM/MeOH extracts (100 μg) of (1) Hypnea musciformis , (2) Pterocladia capillacea , and (3) Ochtodes secundiramea . TLC elution system: hexane:ethyl acetate:methanol (2:7:1 v / v / v ) [ 89 ].…”
Section: Figurementioning
confidence: 99%