Pyrimidine alkaloids from Eudistoma vannamei

Takeara, Renata; Basso, Thiago Olitta; Jimenez, Paula Christine; Costa-Lotufo, Letı́cia V.; Lopes, Norberto Peporine; Lopes, João Luís Callegari

doi:10.1016/j.bjp.2015.08.001

Cited by 5 publications

(2 citation statements)

References 19 publications

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“…Nevertheless, ascidians from the Northeast coast also revealed pharmacological potential, as shown by Jimenez et al [99], where 6 among 10 extracts analyzed displayed some kind of cytotoxic activity, notably that obtained from Eusdistoma vannamei. Subsequent studies with this species, the most abundant one on the coast of Ceará State, led to the identification of purine and pyrimidine derivatives [100,101], a tyrosine peptide derivative [102], and, remarkably, 2 novel alkaloids, 2-hydroxy-7-oxostaurosporine and 3-hydroxy-7-oxostaurosporine (▶ Fig. 6) [103], which presented high selectivity towards cancer cells and induced potent G2-arrest at nM concentrations in a leukemia cell line.…”

Section: Ascidiansmentioning

confidence: 99%

Anticancer Potential of Compounds from the Brazilian Blue Amazon

et al. 2020

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Abstract“Blue Amazon” is used to designate the Brazilian Economic Exclusive Zone, which covers an area comparable in size to that of its green counterpart. Indeed, Brazil flaunts a coastline spanning 8000 km through tropical and temperate regions and hosting part of the organisms accredited for the countryʼs megadiversity status. Still, biodiversity may be expressed at different scales of organization; besides species inventory, genetic characteristics of living beings and metabolic expression of their genes meet some of these other layers. These metabolites produced by terrestrial creatures traditionally and lately added to by those from marine organisms are recognized for their pharmaceutical value, since over 50% of small molecule-based medicines are related to natural products. Nonetheless, Brazil gives a modest contribution to the field of pharmacology and even less when considering marine pharmacology, which still lacks comprehensive in-depth assessments toward the bioactivity of marine compounds so far. Therefore, this review examined the last 40 years of Brazilian natural products research, focusing on molecules that evidenced anticancer potential–which represents ~ 15% of marine natural products isolated from Brazilian species. This review discusses the most promising compounds isolated from sponges, cnidarians, ascidians, and microbes in terms of their molecular targets and mechanisms of action. Wrapping up, the review delivers an outlook on the challenges that stand against developing groundbreaking natural products research in Brazil and on a means of surpassing these matters.

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Section: Ascidiansmentioning

confidence: 99%

Anticancer Potential of Compounds from the Brazilian Blue Amazon

et al. 2020

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“…Este organismo, juntamente com os micro-organismos associados, tem sido um estudado pelo nosso grupo de pesquisa nos últimos 15 anos como uma fonte inestimável de produtos naturais bioativos. Neste contexto, substâncias de diversas classes químicas já foram isoladas dessa ascídia, incluindo estaurosporinas, antraciclinonas, dicetopiperazinas, alcalóides de pirimidina e uma ditiolpirrolona (ABREU et al, 2014;JIMENEZ et al, 2012;SOUSA et al, 2012;TAKEARA et al, 2015 Os organismos marinhos possuem uma variedade de metabólitos secundários, provavelmente como aparato de defesa. Contudo, a maior parte desses metabólitos são produzidos por micro-organismos endossimbióticos.…”

Section: Produtos Naturais Marinhosunclassified