Antinociceptive activity of Sargassum polyceratium and the isolation of its chemical components

Santos, Aline Kely Felício de Sousa; Fonsêca, Diogo Vilar da; Salgado, Paula Regina Rodrigues; Muniz, Vanessa Morais; Torres, Paula de Arruda; Lira, Narlize Silva; Dias, Celidarque da Silva; Pordeus, Liana Clébia de Morais; Barbosa-Filho, José Maria; Almeida, Reinaldo Nóbrega de

doi:10.1016/j.bjp.2015.07.017

Cited by 4 publications

(5 citation statements)

References 31 publications

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“…The rotarod test was performed according to the method previously described by Santos et al [ 7 ] with modification. Mice were subject to a pre-selection process to choose only the mice that remained on the rotarod apparatus (consists of a balance bar) for two min at a constant speed of 16 rpm.…”

Section: Methodsmentioning

confidence: 99%

“…In our quest for naturally occurring antinociceptive compounds from marine resources, we have noticed that most of the research works in this field have been conducted with crude extracts from marine macroalgae [ 5 , 6 , 7 , 8 ], marine sponges [ 9 ], and to a lesser extent, with compounds isolated from macroalgae [ 10 , 11 ] and marine sponges [ 12 ]. To the best of our knowledge, there has been no report on the in vivo antinociceptive activity of crude extracts of marine-derived fungi.…”

Section: Introductionmentioning

confidence: 99%

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Hydroxytakakiamide and Other Constituents from a Marine Sponge-Associated Fungus Aspergillus fischeri MMERU23, and Antinociceptive Activity of Ergosterol Acetate, Acetylaszonalenin and Helvolic Acid

Arias Cardona,

Cerqueira da Silva,

de Lima

et al. 2024

Marine Drugs

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An unreported prenylated indole derivative hydroxytakakiamide (4) was isolated, together with the previously described ergosterol (1), ergosterol acetate (2), and (3R)-3-(1H-indol-3-ylmethyl)-3, 4-dihydro-1H-1,4-benzodiazepine-2,5-dione (3), from the column fractions of the crude ethyl acetate extract of the culture of a marine sponge-associated fungus, Aspergillus fischeri MMERU 23. The structure of 4 was elucidated by the interpretation of 1D and 2D NMR spectral data and high-resolution mass spectrum. The absolute configuration of the stereogenic carbon in 3 was proposed to be the same as those of the co-occurring congeners on the basis of their biogenetic consideration and was supported by the comparison of its sign of optical rotation with those of its steroisomers. The crude ethyl acetate extract and 2 were evaluated, together with acetylaszonalenin (5) and helvolic acid (6), which were previously isolated from the same extract, for the in vivo antinociceptive activity in the mice model. The crude ethyl acetate extract exhibited antinociceptive activity in the acetic acid-induced writhing and formalin tests, while 2, 5, and 6 displayed the effects in the late phase of the formalin test. On the other hand, neither the crude ethyl acetate extract nor 2, 5, and 6 affected the motor performance of mice in both open-field and rotarod tests. Additionally, docking studies of 2, 5, and 6 were performed with 5-lipoxygenase (5-LOX) and phosphodiesterase (PDE) enzymes, PDE4 and PDE7, which are directly related to pain and inflammatory processes. Molecular docking showed that 6 has low affinity energy to PDE4 and PDE7 targets while retaining high affinity to 5-LOX. On the other hand, while 2 did not display any hydrogen bond interactions in any of its complexes, it achieved overall better energy values than 6 on the three antinociceptive targets. On the other hand, 5 has the best energy profile of all the docked compounds and was able to reproduce the crystallographic interactions of the 5-LOX complex.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hydroxytakakiamide and Other Constituents from a Marine Sponge-Associated Fungus Aspergillus fischeri MMERU23, and Antinociceptive Activity of Ergosterol Acetate, Acetylaszonalenin and Helvolic Acid

Arias Cardona,

Cerqueira da Silva,

de Lima

et al. 2024

Marine Drugs

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“…They also comprise a wide array of biomolecules such as proteins, lipids, vitamins, pigments, that can be harnessed for commercial use in food, cosmetic and pharmaceutical industry (23). Also, the pharmacological activities of various bioactive compounds of microalgal origin such as antioxidant, antitumor, antiangiogenic, hemagglutinating and antiviral have been studied (7,24,25).…”

Section: Microalgae As An Inexhaustible Source Of Bioactive Compoundsmentioning

confidence: 99%

“…Moreover, introducing enzymes from other organisms via biotechnological means has succeeded in obtaining novel compounds (6). Owing to their potential as a source of industrial, economic and medical/ pharmaceutical interest microalgae have captured the attention of the scientific community (7).…”

Section: Introductionmentioning

confidence: 99%

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Microalgae as a source of high-value bioactive compounds

et al. 2018

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Microalgae are one of the oldest microorganisms, that grow in various hostile environments, ranging from deserts to Antarctica. The microalgae sustain life in such harsh environments through generation of secondary metabolites. Microalgae biosynthesize a large number of diverse bioactive metabolites with activities on cancer, neurodegenerative diseases, and infectious diseases. Here, we highlight the bioactive compounds that are isolated from microalgae for the purpose of using them as food, and as chemicals in pharmaceutical industry as new agents with therapeutic benefits.

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