New lycosinine derivative from Hippeastrum breviflorum

Revealing the complex genetic structure of cultivated amaryllis (Hippeastrum hybridum) using transcriptome-derived microsatellite markers

“…These plants typically produce between three and six glossy strap-like leaves, which are approximately 600 mm long and 50 mm wide 1 , 3 ; flowers appear simultaneously with the leaves in this genus, and one plant can produce one or two inflorescences. Each of these clusters contains between two and five (mostly four) large trumpet-shaped flowers, which have a scape that is typically hollow and can grow up to 550 mm in size 3 , 4 . Flowers vary from pure white to brilliant red.…”

“…In some parts of the world, such as Bangladesh, agro-ecological conditions are extremely conducive to the survival and culture of amaryllis; thus, this plant exhibits significant local economic potential, including the export market 5 . Amaryllis also contain alkaloids; these plants are able to synthesize eight typical skeletal forms of isoquinoline alkaloids that exhibit a wide range of demonstrated biological functions, including antitumoural, antiviral, antiparasitic, and acetylcholinesterase inhibition properties 4 . These plants therefore also have economic benefits for the pharmaceutical industry given their high alkaloid content 6 .…”

Structural Diversity and Biological Potential of Alkaloids from the Genus Hippeastrum, Amaryllidaceae: an Update

“…In this review, seventeen articles were found to contain the alkaloid profile of twenty-three Hippeastrum extracts (Table S1) published between 2012 and 2021 (de Andrade et al 2014;Carvalho et al 2015;Cortes et al 2015a, b;Sebben et al 2015;Guo et al 2016;Ortiz et al 2016;Bessa et al 2017;Tallini et al 2017;Shammari et al 2019;Gasca et al 2020;Hoang et al 2020;Lianza et al 2020;Feu et al 2021;Paiva et al 2021;Shammari et al 2021;Souza et al 2021).…”

“…) Herb. have been published in the last two decades (Hofmann Jr. et al 2003;Silva et al 2006;Pagliosa et al 2010;de Andrade et al 2011de Andrade et al , 2012ade Andrade et al , 2014Giordani et al 2011;Sebben et al 2015;Tallini et al 2017). Moreover, some contributions in the field of biological activities of AA have also been carried out, such as the anti-inflammatory potential of montanine (3), which brings us a patent licensing (US2016024074) (de Oliveira et al 2015;Farinon et al 2017).…”

Total Syntheses of the Amaryllidaceae Alkaloids Zephycandidine III and Lycosinine A and Their Evaluation as Inhibitors of Acetylcholinesterase

“…Lycosinine B ( 3 ) has since been isolated from the bulbs of Lycoris sprengeri collected from Taizhou City, Zhejiang Province, China and from the bulbs of Hippeastrum breviflorum Herb. Amaryllidaceae (flowering sage) collected in São Francisco de Paula in the Brazilian state of Rio Grande do Sul . No biological activities have been ascribed to the lycosinines thus far, but given the structural resemblance of compound 2 to zephycandidine III, it might also be expected to display AChE‐inhibiting activities.…”