Combined administration of silymarin and vitamin C stalls acetaminophen-mediated hepatic oxidative insults in Wistar rats

Sabiu, Saheed; Sunmonu, Taofik O.; Ajani, Emmanuel Oladipo; Ajiboye, Taofeek O.

doi:10.1016/j.bjp.2014.11.012

Cited by 39 publications

(42 citation statements)

References 33 publications

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“…Metabolic alterations in their concentrations in the serum have also been employed to assess secretory capability of the liver (Oloyede & Sunmonu 2009). In the present study, the APAP-mediated significant reduction in the serum levels of these parameters may be indicative of diminished synthetic function of the liver (Sabiu et al 2015). Bilirubin is an important catabolic product of the blood and its biological value has been utilized to monitor excretory role of the liver (Tietz 1995).…”

Section: Discussionmentioning

confidence: 87%

“…In contrast, phytotherapies have been used in many quarters of the world for the management and treatment of liver ailments for decades without significant side effects (Rajib et al 2009;Mahmud et al 2012;Sabiu et al 2015). Therefore, it is imperative to keep searching for complementary and alternative medicines in phytotherapy for better efficacious, easily accessible, more affordable and safer treatments for liver diseases (Umer et al 2010).…”

Section: Introductionmentioning

confidence: 99%

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Zea mays, Stigma maydisprevents and extenuates acetaminophen-perturbed oxidative onslaughts in rat hepatocytes

Sabiu

Hendrik

Tom

2016

Pharmaceutical Biology

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Context: Zea mays L. (Poaceae) Stigma maydis is an underutilized product of corn cultivation finding therapeutic applications in oxidative stress-related disorders. Objectives: This study investigated its aqueous extract against acetaminophen (APAP)-perturbed oxidative insults in rat hepatocytes. Materials and methods: Hepatotoxic rats were orally pre-and post-treated with the extract (at 200 and 400 mg/kg body weight) and vitamin C (200 mg/kg body weight), respectively, for 14 days. Liver function, antioxidative and histological analyses were thereafter evaluated. Results: The APAP-induced marked (p < 0.05) increases in the activities of alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, gamma glutamyl transferase and the concentrations of bilirubin, oxidized glutathione, protein carbonyls, malondialdehyde, conjugated dienes, lipid hydroperoxides and fragmented DNA were dose-dependently extenuated in the extract-treated animals. The extract also significantly (p < 0.05) improved the reduced activities of superoxide dismutase, catalase, glutathione reductase and glutathione peroxidase as well as total protein, albumin and glutathione concentrations in the hepatotoxic rats. These improvements may be attributed to the bioactive constituents as revealed by the gas chromatography-mass spectrometric chromatogram of the extract. The observed effects compared favourably with vitamin C and are informative of hepatoprotective and antioxidative attributes of the extract and were further supported by the histological analysis. Conclusion: The data from the present findings suggest that Stigma maydis aqueous extract is capable of preventing and ameliorating APAP-mediated oxidative hepatic damage via enhancement of antioxidant defence systems. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Zea mays, Stigma maydisprevents and extenuates acetaminophen-perturbed oxidative onslaughts in rat hepatocytes

Sabiu

Hendrik

Tom

2016

Pharmaceutical Biology

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“…The haematological and clinical biochemistry parameters investigated in this study are useful indices to ascertain the safety profiles of plant extracts in metabolically active experimental animals [16]. The non-significant differences in the hematological indices for the control rats and the extract-treated animals in the acute toxicity test following the 28-days repeated dosing treatment with CDE could be suggestive of its non-toxic effect on the hematopoietic system.…”

Section: Discussionmentioning

confidence: 89%

“…Probable signs of toxicity, morbidity, and mortality were monitored throughout the investigation period. The feed and water intakes were monitored daily and the average calculated at every 4-day interval, while their body weights were measured at the initial and on weekly basis throughout the period of 28 days [16]. At the end of the experiment, all the rats were anesthetized using halothane and blood samples were similarly collected and processed as detailed in the acute toxicity study.…”

Section: Sub-acute Toxicity Testmentioning

confidence: 99%

Toxicity assessment of aqueous extract of <i>Curtisia dentata</i> (Burm.f) C.A. Sm: stem bark in male Wistar rats

Wintola¹,

Afolayan²

2018

Trop. J. Pharm Res

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“…In the present study, the significantly increased serum level of bilirubin in the untreated hepatotoxic rats could be associated with CCl 4 -mediated defect in the carriermediated saturable system at the sinusoidal surface of the hepatocytes that consequently obstruct bilirubin uptake and secretion into bile . Similarly, the CCl 4 -mediated significant reduction in the levels of albumin and total protein may be suggestive of diminished synthetic function of the liver (Sabiu et al, 2015). Conversely, the dose-dependent and significant improvements in albumin and total protein levels coupled with the reduced concentration of bilirubin in the extracttreated rats is indicative of aided secretory and excretory functions of the hepatocytes facilitated by the EOAE.…”

Section: Discussionmentioning

confidence: 97%

Mechanism of hepatoprotective potential of aqueous leaves extract of Eucalyptus obliqua (Myrtaceae) in carbon tetrachloride intoxicated Wistar rats

2017

J App Pharm Sci

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This study investigated the protective mechanism of aqueous leaves extract of Eucalyptus obliqua (EOAE) in CCl4-mediated liver damage in Wistar rats. The animals were orally pretreated with either the extract (200 and 400 mg/kg) or vitamin C (200 mg/kg) for 10 days prior to the intraperitoneal administration of 3 mL/kg CCl4 (30% in olive oil). Subsequently, hepatic function, antioxidant and histological analyses were evaluated. The results showed that the CCl4-induced increases in the activities of ALT, ALP, AST and the concentrations of bilirubin, oxidized glutathione and malondialdehyde were significantly and dose-dependently reduced in the extract-treated rats. The extract also significantly improved the attenuated activities of superoxide dismutase, catalase, glutathione reductase and glutathione peroxidase as well as total protein, albumin and glutathione concentrations in the hepatotoxic animals. These improvements could be attributed to the phytoconstituents revealed by the GCMS analysis of the extract. The observed activities compared with that of vitamin C and are suggestive of hepatoprotective and antioxidant properties of EOAE and were also supported by the histological results. Overall, these data indicate that EOAE has a significant protective effect against acute CCl4-induced hepatotoxicity in rats, which may be due to its capability to fortify the antioxidant defense systems.

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Combined administration of silymarin and vitamin C stalls acetaminophen-mediated hepatic oxidative insults in Wistar rats

Cited by 39 publications

References 33 publications

Zea mays, Stigma maydisprevents and extenuates acetaminophen-perturbed oxidative onslaughts in rat hepatocytes

Zea mays, Stigma maydisprevents and extenuates acetaminophen-perturbed oxidative onslaughts in rat hepatocytes

Toxicity assessment of aqueous extract of <i>Curtisia dentata</i> (Burm.f) C.A. Sm: stem bark in male Wistar rats

Mechanism of hepatoprotective potential of aqueous leaves extract of Eucalyptus obliqua (Myrtaceae) in carbon tetrachloride intoxicated Wistar rats

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