Nanoparticles containing curcuminoids (Curcuma longa): development of topical delivery formulation

Zamarioli, Cristina Mara; Martins, Ronei Ximenes; Carvalho, Emı́lia Campos de; Freitas, Luís Alexandre Pedro de

doi:10.1016/j.bjp.2014.11.010

Cited by 47 publications

(27 citation statements)

References 29 publications

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“…The formulation containing SLNcurcuminoids showed good spreadability and stability. As a result of slow release, nano-encapsulated curcuminoids showed no permeation or penetration when assayed using pig ear skin during 18 h. The study concluded that the topical formulation is stable and can be used for the treatment of inflammatory reactions such as radiodermits [37].…”

Section: Priyanka and Bhattacharyyamentioning

confidence: 94%

A Review on Promising Antibiotic Therapy by Novel Delivery Systems

Priyanka¹,

Bhattacharyya²

2018

Asian J Pharm Clin Res

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The introduction of a new moiety of drugs for antibiotics in the market is getting declined. Antibiotic resistance is a major threat to human health worldwide. Many life-saving antibiotic drugs are rendered ineffective. Resistant bacterial infections are difficult to treat because of the poor response to antibiotics. Hence, utilizing the novel methods/approaches for the development of formulation into its novel delivery can prevent bacterial resistance. This review article explores the various promising approaches for delivery of antibiotics in the form of liposomes, solid lipid nanoparticles, microspheres, dendrimers, inhaled antibiotics, and polymeric particles. These approaches of delivery have been proven to provide innovative and novel delivery of antibiotic by enhancing the therapeutic effectiveness, targeting at the site of action, enhanced activity, and penetrability at intracellular pathogens, thereby reducing side effects, toxicity, and the chances of bacterial resistance.

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Section: Priyanka and Bhattacharyyamentioning

confidence: 94%

A Review on Promising Antibiotic Therapy by Novel Delivery Systems

Priyanka¹,

Bhattacharyya²

2018

Asian J Pharm Clin Res

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“…Some techniques, such as nanoparticles, phospholipid complexes, and liposomes, have been used as drug delivery systems to improve the bioavailability of these substances [61,62]. Some compounds, such as folic acid, piperine, phosphatidylcholine, galactose, and the complex arginine-glycine-aspartic acid, are also used to improve this bioavailability and effects.…”

Section: Disadvantages Of Curcuma Longamentioning

confidence: 99%

Alternative Therapeutic Approach for Cartilage Repair

Akuri¹,

Barion²,

Barbalho³

et al. 2018

Cartilage Repair and Regeneration

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The cartilage is a flexible tissue, which supports the adjacent soft tissues. The damages that cause degenerative articular diseases are marked by the increase of cytokines such as tumor necrosis factor-α (TNF-α), IL-1β, IL-6, IL-18, and IL-17, which cause intense inflammatory process and release of metalloproteinases and disintegrin enzymes that lead to cartilage degradation. The Curcuma longa possessesbioactivecompoundsdesignatedascurcuminoids that display therapeutic potential in several pathologies. Curcumin is one of these compounds that may exhibit anti-inflammatory, antioxidant, antiviral, antibacterial, and antitumor effects. It may promote decrease of IL-1β,IL-6,IL-8,TNF-α,COX-2,andreactive oxygen species. Furthermore, curcumin inhibits the activity of several kinases related to the degradation of the cartilage, including tyrosine kinase, p21-activated kinase, mitogenactivated protein kinase, protein kinase C, the activator protein 1 pathway, and NF-κB leading to the suppression of the production of metalloproteinases and inflammatory cytokines. Curcumin has also been related to the stimulation of the production of type II collagen and glycosaminoglycan by chondrocytes. Studies have shown that this compound may alleviate joint pain and crepitation, reduce the use of other drugs for pain relief, stimulate the production of type II collagen and glycosaminoglycan resulting in a protective and antiinflammatory action of cartilage and bones, and improve the quality of life of the patients.

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“…This packaging of curcumin showed enhanced activity in hydrogels prepared for inflammation treatment of porcine skin. 132 However, some solid lipid nanoparticles showed a higher particle size with the addition of quercetin, an average of 574 nm. This size can be reduced with the addition of silica, decreasing the average size to 483 nm causing enhanced skin penetration of quercetin with higher photostability and skin protection.…”

Section: Solid Lipid Nanoparticlesmentioning

confidence: 99%

Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy

Ganesan¹,

Choi²

2016

IJN

121

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Phytocompounds have been used in cosmeceuticals for decades and have shown potential for beauty applications, including sunscreen, moisturizing and antiaging, and skin-based therapy. The major concerns in the usage of phyto-based cosmeceuticals are lower penetration and high compound instability of various cosmetic products for sustained and enhanced compound delivery to the beauty-based skin therapy. To overcome these disadvantages, nanosized delivery technologies are currently in use for sustained and enhanced delivery of phyto-derived bioactive compounds in cosmeceutical sectors and products. Nanosizing of phytocompounds enhances the aseptic feel in various cosmeceutical products with sustained delivery and enhanced skin protecting activities. Solid lipid nanoparticles, transfersomes, ethosomes, nanostructured lipid carriers, fullerenes, and carbon nanotubes are some of the emerging nanotechnologies currently in use for their enhanced delivery of phytocompounds in skin care. Aloe vera , curcumin, resveratrol, quercetin, vitamins C and E, genistein, and green tea catechins were successfully nanosized using various delivery technologies and incorporated in various gels, lotions, and creams for skin, lip, and hair care for their sustained effects. However, certain delivery agents such as carbon nanotubes need to be studied for their roles in toxicity. This review broadly focuses on the usage of phytocompounds in various cosmeceutical products, nanodelivery technologies used in the delivery of phytocompounds to various cosmeceuticals, and various nanosized phytocompounds used in the development of novel nanocosmeceuticals to enhance skin-based therapy.

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Nanoparticles containing curcuminoids (Curcuma longa): development of topical delivery formulation

Cited by 47 publications

References 29 publications

A Review on Promising Antibiotic Therapy by Novel Delivery Systems

A Review on Promising Antibiotic Therapy by Novel Delivery Systems

Alternative Therapeutic Approach for Cartilage Repair

Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy

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