Ulcer protective potential of standardized hesperidin, a citrus flavonoid isolated from Citrus sinensis

Bigoniya, Papiya; Singh, Kanhaiya

doi:10.1016/j.bjp.2014.07.011

Cited by 64 publications

(42 citation statements)

References 32 publications

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“…It is known that gastric injuries caused by NSAIDs are associated with reactive oxygen species (ROS) generation (Bigoniya & Singh, ) and attenuation of mucin and prostaglandins synthesis (Niv, ; Tomisato et al, ).…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and gastroprotective actions of butanol fraction ofZingiber officinaleagainst diclofenac sodium-induced gastric damage in rats

et al. 2017

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This study was designed to investigate the antioxidant and antiulcer activities of flavonoid‐rich fractions of Zingiber officinale extract. The fractions, obtained by solvents of increasing polarities, were subjected to 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging activity. The fraction which possessed the highest antioxidant activity was used to assess gastroprotective action against diclofenac sodium induced gastric ulcer in rats. Chromatographic profiling was carried out using LC‐ESI‐MS analysis. The butanol fraction (BF) showed the strongest antioxidant potential and the results of the in vivo study revealed that BF at 100 mg/kg protected against gastric lesions. At the same dose, BF prevented diclofenac sodium‐induced increase in tumor necrosis factor alpha (TNF‐α) and malondialdehyde (MDA) levels, and depletion of catalase (CAT) activity as well as glutathione (GSH) and prostaglandin E2 (PGE2) contents. LC‐ESI‐MS analysis revealed the presence of 12 phenolic compounds. BF exerted antiulcer action which could be linked to the presence of phenolic compounds. Practical applications Zingiber officinale has been widely consumed as a spice and used in folk medicine for treatment of gastric disorders. This is the first report evaluating the pharmacological effects of the butanol extract of ginger for the prevention of gastric ulcer. The results showed that the extract affords better gastroprotective activity against diclofenac sodium‐induced gastric ulcer in rats by reducing oxidative stress. Information provided in this study will be beneficial for developing applications of ginger in food biotechnology as functional and nutraceutical ingredient.

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Section: Discussionmentioning

confidence: 99%

Antioxidant and gastroprotective actions of butanol fraction ofZingiber officinaleagainst diclofenac sodium-induced gastric damage in rats

et al. 2017

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“…Hesperidin, a flavanone glycoside, is found abundantly in lemons and oranges [13]. It has been extensively studied for its biological activities including antioxidant, anti-inflammatory, antihypercholesterolemic, and anticarcinogenic properties [17,[22][23][24][25].…”

Section: Discussionmentioning

confidence: 99%

“…Hesperidin, a flavanone glycoside, is found abundantly in lemons and oranges [13]. Previous reports have confirmed the antioxidant activity and radical scavenging properties of hesperidin using a variety of assay systems [14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Hesperidin Alleviates Oxidative Stress and Upregulates the Multidrug Resistance Protein 2 in Isoniazid and Rifampicin‐Induced Liver Injury in Rats

Zhang

Zhu

Zhou

et al. 2016

J Biochem & Molecular Tox

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Isoniazid (INH) and rifampicin (RFP), two front-line drugs used in tuberculosis therapy, may lead to seriously hepatotoxicity. The current study was carried out to investigate the hepatoprotective effects of hesperidin against INH-and RFP-induced oxidative damage. The liver injury animal model of rats was induced by INH (75 mg/kg) and RFP (150 mg/kg) coadministration for 7 days, and hesperidin, at the dose of 50, 100, and 200 mg/kg, was orally administered to rats 2 h before INH and RFP administration. The biochemical and pathologic examinations were performed after rats were sacrificed. Moreover, the serum and liver glutathione (GSH), glutathione disulfide (GSSG), malondialdehyde (MDA), GSH peroxidase, and GSSG reductase were determined by test kits, and the expression of multidrug resistance proteins 2 (Mrp2) was determined by Western blotting and immunohistochemistry. The results showed that hesperidin significantly alleviated liver injury as indicated by the decreased levels of ALT, AST, bilirubin, total bile acid, and glutathione peroxidase and the increased levels of the GSH/GSSG ratio and the expression of Mrp2. Moreover, hesperidin could effectively reduce the pathological tissue damage. These results indicate that hesperidin can attenuate INH-and RFP-induced oxidative damage, and the underlying mechanism may have correlation with its effect on the upregulation of Mrp2.

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“…Natural antioxidants from fruits offer an alternative source of dietary ingredients to promote healthy life. In vivo studies show that epigallocatechin gallate contained in green tea is able to inhibit memory deficits in Alzheimer case [1], hesperidin isolated from citrus peels allows the regeneration of ulcerated tissue and prevents hemorrhagic injury of gastric mucosa [2], polyphenols in cocoa bean can reduce the risk of atherosclerosis [3], anthocyanins isolated from blueberry exhibits protection on liver [4], xanthones in mangosteen can protect nervous system [5], flavonoids of polymethoxylated flavones, procyanidins and isoflavones tyrosinase in several extracts (tangerine peels, cocoa and red clover) is potent to treat Parkinson's disease [6], and so forth. Basically, the assessment on antioxidant activity of plant extracts has lately received great attention.…”

Section: Introductionmentioning

confidence: 99%

Design of kaffir lime peel extract tablets by direct compression: Effects of filler-binder on rheological properties

Irawaty

Hadisoewignyo

Wijaya

et al. 2019

EXPLORING RESOURCES, PROCESS AND DESIGN FOR SUSTAINABLE URBAN DEVELOPMENT: Proceedings of the 5th International Conference on E

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Dried kaffir lime peels from Citrus hystrix were extracted with ethanol by maceration method, followed by solvent evaporation to obtain dry extract. Due to economical aspect and good flow properties of the extract, a direct compression method was applied in making the tablets. The main objective of this study was to study the influence of filler-binder (Avicel PH 102, Emcompress and Lactose) on rheological properties of kaffir lime peel extract tablet dough. Firstly, kaffir lime peel extract was prepared by peeling, cutting and drying kaffir lime peels prior to soaking them to ethanol. After separating the solid part, the extract was subsequently concentrated and filler was added into the crude extract to obtain dry product. Secondly, dry extract was then combined with filler-binder, sweetener and lubricant prior to the compression. Rheological properties evaluated in this study were density, flow time, the Carr index and the Hausner ratio. Thirdly, the best formulation dough was compressed to produce tablets. From the results, it can be concluded that ethanol is the best solvent to extract polyphenols from kaffir lime peels. In addition, the use of a mixture of lactose and Avicel PH 102 as the filler-binder agent exhibited the best formulation.

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Ulcer protective potential of standardized hesperidin, a citrus flavonoid isolated from Citrus sinensis

Cited by 64 publications

References 32 publications

Antioxidant and gastroprotective actions of butanol fraction ofZingiber officinaleagainst diclofenac sodium-induced gastric damage in rats

Antioxidant and gastroprotective actions of butanol fraction ofZingiber officinaleagainst diclofenac sodium-induced gastric damage in rats

Hesperidin Alleviates Oxidative Stress and Upregulates the Multidrug Resistance Protein 2 in Isoniazid and Rifampicin‐Induced Liver Injury in Rats

Design of kaffir lime peel extract tablets by direct compression: Effects of filler-binder on rheological properties

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