Are ethnopharmacological surveys useful for the discovery and development of drugs from medicinal plants?

Albuquerque, Ulysses Paulino; Medeiros, Patrícia Muniz de; Ramos, Marcelo Alves; Júnior, Washington Soares Ferreira; Nascimento, Aguinaldo José do; Avilez, Wendy Marisol Torres; Melo, Joabe Gomes de

doi:10.1016/j.bjp.2014.04.003

Cited by 43 publications

(27 citation statements)

References 32 publications

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“…In addition to the novel bioactive compounds isolated, the recent upsurge in pharmacological potentials for phytoantioxidants, phytoantimicrobial pharmacophore, and tolerance of A. decurrens for native invader has been a source of motivation for the study of invasive vegetation as a source of the lead compound [8]. The selection of A. decurrens is not solely dependent on ethnopharmacological knowledge or traditional uses but by direct testing and bioassay-guided isolation of compounds [11]. The generic protocol for the drug discovery from natural products is employed in the study using bioassay-guided in vitro testing of the plant extracts and eventual isolation and identification of the bioactive compounds (see graphical abstract).…”

Section: Introductionmentioning

confidence: 99%

New Pharmacophore from the Stem Bark Fractions of Acacia decurrens (Willd), an Invasive South Africa Tree

Okoli

Modise

2017

Journal of Applied Chemistry

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The tolerance of Acacia decurrens, an invasive species, was exploited pharmacologically in this study. Phytochemical screening revealed important secondary metabolites. Importantly, the assay shows that ethyl acetate and methanol fractions are sources of phytochemicals compared to the hexane and chloroform fractions. A bioassay-guided in vitro assay of the extracts led to the eventual isolation of four bioactive compounds by column chromatography, identification, and characterisation with the aid of GCMS, UV-Vis, FTIR, and NMR. The antimicrobial screening by disc diffusion assay revealed 22.2%, 44.4%, 66.7%, and 77.8% microbial inhibition by 2-methyl-octahydro-indene-4-carboxylic acid (AD1), 6-methyldecahydro-1H-phenanthren-9-one (AD2), 8-hydroxytetradecahydro-chrysene-1-carb aldehyde (AD3), and 8,9-dihydroxy-7-(2-hydroxy-ethyl)-9,9a-hexahydro-1H,3H-2-thia-5a-aza cyclopenta [b]anthracen-6-one (AD4), respectively. Compounds AD3 and AD4 are the most potent antibacterial compounds against Gram-positive bacteria with MIC 12.5-6.25 g/ml. Antioxidant study of the compounds assayed with DPPH and ABTS•+ revealed that compound (AD4) is the most efficient DPPH radical scavenger with IC50 30.07 ± 0.31 and ABTS•+ scavenging activity of 4363.2 ± 452.4 mol of TE/gDW. This provides scientific information on four pharmacophores with phyto-antioxidants and antimicrobial potential, despite the classification of A. decurrens as a Category 2 invasive plant by the National Water Act.

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Section: Introductionmentioning

confidence: 99%

New Pharmacophore from the Stem Bark Fractions of Acacia decurrens (Willd), an Invasive South Africa Tree

Okoli

Modise

2017

Journal of Applied Chemistry

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“…2.5). However, in spite of the richness of the ethnopharmacological surveys worldwide and diversity of traditional knowledge, many of the collected data could not be translated successfully into bioprospecting programmes (Albuquerque et al, 2014).…”

Section: Ethnobotany-directed Drug Discoverymentioning

confidence: 99%

“…It is a fact that only a few significant contributions have been made by ethno-directed approach in the last few decades (Gertsch, 2009). Research problems like inadequate design for data collection, misinterpretation of the role of medicinal play in the traditional medicine system, unfavourable influence of sampling, and application of irrelevant informant consensus indices hampered ethnobotanical-directed drug discovery programmes, individually or in combination (Albuquerque et al, 2014).…”

Section: Ethnobotany-directed Drug Discoverymentioning

confidence: 99%

Prediction of Medicinal Properties Using Mathematical Models and Computation, and Selection of Plant Materials

Ningthoujam

Talukdar

Sarker

et al. 2018

Computational Phytochemistry

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“…8 This is justified by the fact that the intrinsic features of Caatinga area (drought, high solar radiation rates and other environmental stresses) influence the synthesis of secondary metabolites of its plants, 9 making them attractive targets for bioprospecting programs. 10 In traditional medicine, Anadenanthera colubrina (Vell.) Brenan var.…”

Section: Introductionmentioning

confidence: 99%

Effects of Rainfall on the Antimicrobial Activity and Secondary Metabolites Contents of Leaves and Fruits of Anadenanthera colubrina from Caatinga Area

Araújo¹,

Silva²,

Harand³

et al. 2017

Phcog J

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Background: Anadenanthera colubrina (Vell.) Brenan var. cebil (Griseb) is a plant widely used for medicinal proposes in Brazilian Northeast. Objective: This study aimed to analyze the influence of rainfall indexes (RI) in antimicrobial activity and phytochemical constituents of extracts from leaves and fruits of A. colubrina. Material and Methods: Samples were collected in Catimbau National Park (Buíque, Pernambuco, Brazil) at September 2010 (RI: 75 mm) and January (RI: 65 mm), April (RI: 162 mm) and June 2011 (RI: 73 mm). The extracts were prepared by Soxhlet extraction using cyclohexane, chloroform, ethyl acetate and methanol. The antimicrobial activity was determined by MIC and MBC values. Results: All extracts showed antimicrobial activity, but ethyl acetate extracts (from all periods) were more active. Strong correlations were found between the RI and the average MIC of MLE (ρ: -0.99), EALE (ρ: -0.81), CHFE (ρ: -0.81), EAFE (ρ: -0.80); while moderate and weak correlations were found for other extracts. Through a HPLC analysis was possible to reveal that the samples collected from dry periods had more chemical diversity (as they presented more peaks). Gallic acid and quercetin (and derivative compounds) were identified. The levels of quercetin were enhanced in extracts from dry months. Conclusion: Our results showed that the rainfall has a positive effect on the antimicrobial activity of leaves and fruits of A. colubrina, however these extracts showed more chemical diversity during dry months.

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Are ethnopharmacological surveys useful for the discovery and development of drugs from medicinal plants?

Cited by 43 publications

References 32 publications

New Pharmacophore from the Stem Bark Fractions of Acacia decurrens (Willd), an Invasive South Africa Tree

New Pharmacophore from the Stem Bark Fractions of Acacia decurrens (Willd), an Invasive South Africa Tree

Prediction of Medicinal Properties Using Mathematical Models and Computation, and Selection of Plant Materials

Effects of Rainfall on the Antimicrobial Activity and Secondary Metabolites Contents of Leaves and Fruits of Anadenanthera colubrina from Caatinga Area

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