The prognostic value of peripheral blood parameters on all-frequency sudden sensorineural hearing loss

Sun, Haitao; Jiang, Wenbo; Wang, Jian

doi:10.1016/j.bjorl.2023.101302

Cited by 1 publication

(1 citation statement)

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“…Moreover, they suggested that hyperfibrinogenemia may not be directly related to the cause of SSHL, but rather to the severity of the disease. Also, Sun et al [21] in 2023 found that blood fibrinogen level is a reliable indicator of the prognosis of SSHL when all frequencies are affected. In addition, recent studies have confirmed that thrombosis occurring in the inner ear can lead to a reduction in blood flow.…”

Section: Fibrinogenmentioning

confidence: 99%

The Role of Fibrinogen, Homocysteine and Metabolic Syndrome’s Alterations in Sudden Sensorineural Hearing Loss (SSHL): A Narrative Review

Monzani,

Liberale,

Segato

et al. 2023

Medicina

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Fibrinogen and homocysteine (HCY) are molecules known to play a role in vascular homeostasis, and their blood levels are often elevated in patients with metabolic syndrome. Recent evidence suggests that sudden sensorineural hearing loss (SSHL) may have a vascular origin. This has led many authors to advocate that fibrinogen, homocysteine, and metabolic syndrome (MetS) may play a direct role in SSHL. The aim of this brief review is to examine the role and influence of these molecules and MetS on the mechanisms of SSHL. Elevated fibrinogen levels have been associated with a worse prognosis in SSHL, possibly due to increased blood viscosity and decreased blood flow. Similarly, HCY has been associated with vascular damage, particularly in hyperhomocysteinemia, although the exact association with SSHL remains controversial. MetS has been demonstrated to function both as a causative factor and as a contributor to poorer recovery in cases of SSHL. However, although some studies suggest a possible role for these biomarkers and MetS in the prognosis and treatment of SSHL, specific therapeutic and preventive strategies based solely on these factors have yet to be developed. Given their potential role in prognosis and treatment and the global epidemic of metabolic syndrome, this issue needs to be analyzed comprehensively. Thus, further quality studies need to be conducted, even though it is difficult to determine the actual impact of MetS on the development of SSHL, as it is a multifactorial disease affecting multiple organs.

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Section: Fibrinogenmentioning

confidence: 99%