MicroRNA-150-5p inhibits the proliferation and invasion of human larynx epidermiod cancer cells though regulating peptidyl-prolyl cis/trans isomerase

Chen, Hailin; Cai, Xuwei; Du, Baowen; Cai, Jianpiao; Luo, Zhengzheng

doi:10.1016/j.bjorl.2023.03.003

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…Recent in vitro studies on human LSCC Hep-2 cell lines found that miR-33a, miR-199a-5p, miR-145, miR-34a, and miR-150-5p overexpression promoted cancer cell apoptosis, suggesting a role as tumor suppressor [86][87][88][89][90]. A study carried out on 97 patients with LSCC demonstrated that low expression levels of miR-196b are related to worse overall survival (median survival: 48 months), while its overexpression is related to better survival (median survival: 81 months) (p-value 0.04) [91].…”

Section: Micro Ribonucleic Acids (Mirnas)mentioning

confidence: 99%

Biomarkers in Laryngeal Squamous Cell Carcinoma: The Literature Review

Verro,

Saraniti,

Carlisi

et al. 2023

Cancers

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Laryngeal squamous cell carcinoma (LSCC) is the second most common cancer among head and neck cancers. Despite a lower incidence of laryngeal carcinoma, new diagnostic techniques, and more targeted therapies, the overall survival has not changed significantly in the last decades, leading to a negative prognosis in advanced stages. Recently, several studies have focused on the identification of biomarkers that may play a critical role in the pathogenesis of LSCC. Reviewing the literature on the main databases, this study aims to investigate the role of some biomarkers in LSCC that are correlated with oxidative stress and inflammation: heat shock proteins; metallothioneins; nuclear factor erythroid 2-related factor 2; heme oxygenase; cyclooxygenase-2; and micro ribonucleic acids. This review shows that biomarker expression depends on the type, grade of differentiation, stage, and site of carcinoma. In addition, the role of these biomarkers in LSCC is still little-known and little-studied. However, the study of biomarker expression and the detection of a possible correlation with patients’ epidemiological, clinicopathological, and therapeutics data may lead to better awareness and knowledge of the tumor, to the identification of the best therapeutic strategy, and the most proper follow-up protocol tailored for each patient. In conclusion, the achievement of these goals may improve the prognosis of LSCC patients.

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Section: Micro Ribonucleic Acids (Mirnas)mentioning

confidence: 99%

Biomarkers in Laryngeal Squamous Cell Carcinoma: The Literature Review

Verro,

Saraniti,

Carlisi

et al. 2023

Cancers

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MicroRNA-150-5p-mediated Inhibition of Cell Proliferation, G1/S Transition, and Migration in Bladder Cancer through Targeting NEDD4-binding Protein 2-like 1 Gene

Rao,

Li,

Xiong

et al. 2024

Journal of Physiological Investigation

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MicroRNA-150-5p (miR-150-5p) has been implicated in the progression of several cancer types, yet its specific functional role and regulatory mechanisms in bladder cancer (BC) remain largely unexplored. Our study revealed significant downregulation of miR-150-5p and upregulation of NEDD4-binding protein 2-like 1 gene (N4BP2L1) in BC tissues compared to controls using quantitative real-time polymerase chain reaction and western blot analysis, respectively. Reduced miR-150-5p expression correlated with advanced tumor stage and lymph node metastasis, while increased N4BP2L1 levels were associated with larger tumor size by the Chi-square test. Functionally, miR-150-5p exerted significant inhibitory effects on BC cell proliferation, migration, inducing G0/G1 phase arrest, and apoptosis. We confirmed N4BP2L1 as a direct target of miR-150-5p in BC cells using luciferase reporter assay. Crucially, N4BP2L1 knockdown mimicked, while overexpression counteracted the inhibitory impacts of miR-150-5p on BC cell proliferation, migration, and invasion. In addition, N4BP2L1 overexpression reversed miR-150-5p-induced alterations in CDK4, Cyclin D1, Bcl-2, PCNA, Ki-67, N-cadherin, Bad, and E-cadherin levels in BC cells. Based on these results, it can be inferred that the miR-150-5p/N4BP2L1 axis might constitute a promising candidate for therapeutic targeting in the treatment of BC.

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MicroRNA-150-5p inhibits the proliferation and invasion of human larynx epidermiod cancer cells though regulating peptidyl-prolyl cis/trans isomerase

Cited by 2 publications

References 34 publications

Biomarkers in Laryngeal Squamous Cell Carcinoma: The Literature Review

Biomarkers in Laryngeal Squamous Cell Carcinoma: The Literature Review

MicroRNA-150-5p-mediated Inhibition of Cell Proliferation, G1/S Transition, and Migration in Bladder Cancer through Targeting NEDD4-binding Protein 2-like 1 Gene

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