Effects of nigella sativa oil on allergic rhinitis: an experimental animal study

Gul, Recep; Tansuker, Hasan Deniz; Cengiz, Abdurrahman Buğra; Gul, Melda; Tabaru, Alper; Emre, Funda; Oktay, Mehmet Faruk

doi:10.1016/j.bjorl.2022.09.003

Cited by 4 publications

(3 citation statements)

References 25 publications

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“…The anti-inflammatory and anti-allergic effects of NSO as equally effective as mometasone furoate in the treatment of experimentally generated AR. [9] TQ, the active ingredient in NSO is a potent anti-inflammatory agent and was shown to inhibit allergic airway inflammation by inhibiting Th2 cytokines and eosinophil infiltration into lungs, in a mouse model of allergic lung inflammation. [29] TQ was also shown to have immunomodulatory activities mediated by Nuclear Factor Kappa B and Phosphoinositide 3-Kinase/Akt pathways and antioxidant effect by upregulation of nuclear factor erythroid 2-related factor 2 and HO-1 proteins and decrease the levels of Tumor Necrosis Factor Alpha and IL-4 in activated Rat Basophilic Leukemia Cells-2H3 cells.…”

Section: Discussionmentioning

confidence: 99%

“…It is well-recognized that black seeds can help manage metabolic diseases, hypertension, allergy, asthma respiratory illness, infectious diseases, celiac diseases, bronchial asthma, headaches, dysentery, infections, obesity, back pain, hypertension, and gastrointestinal issues. [9][10][11][12] The oil component of N sativa, constituting almost 36% to 38% of the total components contains various pharmacologically active compounds, such as thymoquinone (TQ), thymohydroquinone, dithymoquinone, thymol, carvacrol, nigellidine, nigellicine, and α-hederin, which are responsible for its therapeutic benefits. [11] The pharmacological effect of N sativa oil (NSO) and its constituents have been studied in cellular and animal models of respiratory diseases and have been reported to possess antihistaminic, anti-inflammatory, anti-leukotrienes, anti-fibrotic, and immunomodulatory effects.…”

Section: Introductionmentioning

confidence: 99%

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A randomized, double-blind, placebo-controlled study to evaluate the benefits of a standardized Nigella sativa oil containing 5% thymoquinone in reducing the symptoms of seasonal allergy

Majeed,

Parameswarappa

et al. 2024

Medicine

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Background: Allergic rhinitis (AR) or seasonal allergy characterized by sneezing, nasal congestion, nasal itching, and nasal discharge, triggered by immune reactions to environmental allergens. Present day customers also monitor the personal improvements in the area of Evidence-Based natural medicines/supplements Methods: A randomized, double-blind, placebo-controlled study was conducted on 65 participants aged 18 to 60 years having 2 or more allergic symptoms like sneezing, rhinorrhoea, nasal obstruction, and nasal itching for a cumulative period greater than 1 hour per day. The study participants received a capsule of NSO (250 mg) with 2.5 mg piperine (BioPerine) as a bioavailability enhancer or a placebo, twice a day, after food for 15 days. The primary objectives were evaluated by mean change in Total Nasal Symptom Score and the duration of AR symptoms per day from baseline to Day 15. Secondary endpoints were changes in Total Ocular Symptoms Score, AR symptom frequency and severity, serum Immunoglobulin E levels, and Patient Global Impression of Change scale. Adverse events were monitored throughout the study. Results: Sixty-five patients were enrolled and all of them completed the study, N = 33 in NSO and N = 32 in placebo. A significant reduction in Total Nasal Symptom Score and Total Ocular Symptoms Score was observed in the NSO group compared to the placebo, highlighting the potential of NSO in alleviating AR symptoms. The episodes of AR symptoms per day and the frequency of symptoms in 24 hours reduced significantly in 15 days in both groups, but the extent of improvement was significantly higher in NSO compared to placebo. Improvement in Patient Global Impression of Change was also significantly better in NSO compared to the placebo. Serum Immunoglobulin E levels decreased in NSO but were not significantly different from placebo. No clinically significant changes were observed in vital signs, liver and renal function, lipid profile, hematology, fasting blood sugar, or urine analysis at the end of the study. Conclusion: The result of the study demonstrates that NSO 250 mg with 2.5 mg piperine is an effective and well-tolerated supplement for the management of AR symptoms.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A randomized, double-blind, placebo-controlled study to evaluate the benefits of a standardized Nigella sativa oil containing 5% thymoquinone in reducing the symptoms of seasonal allergy

Majeed,

Parameswarappa

et al. 2024

Medicine

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“…According to the findings obtained from this study, it was found that antiinflammatory and anti-allergic effects of Nigella sativa oil as equally effective as mometasone furoate in the treatment of experimentally generated allergic rhinitis. 76 Adjunctive intervention in obesity management: or as a beneficial dietary element in treating obesity and associated issues:…”

Section: Gastro-protective Activitymentioning

confidence: 99%

A Comprehensive review of Nigella sativa (kalonji) from the Unani perspective

Alam,

Bhat,

Rather

et al. 2023

J. Drug Delivery Ther.

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The remarkable therapeutic properties of Nigella sativa, often known as black seed or kalonji are well recognized. The use of N. sativa seeds and its oil has a long history in various traditional food and medical systems. As stated by the holy prophet of Islam (PBUH), Shoneez is important since it can cure all diseases with the exception of death. It is widely used in several conventional medical systems, including Unani Tibb, Chinese medicine, Ayurveda, and Siddha. The goal of the current review is to provide a thorough overview of the literature on scientific studies of the pharmacognostical properties, chemical makeup, and pharmacological activity of the seeds of this plant. The data was collected from various reputed data bases like PubMed, Science direct, Web of Saciences, Google Scholar and Research Gate. The traditional and Unani literature was also searched from the classical books of Greco-Arab medicine in addition to other digital sources. According to traditional Unani literature, N. sativa exhibits a variety of pharmacological properties, including those that are carminative, anti-inflammatory, analgesic, diuretic, emmenagogue, galactagogue, and expectorant. Numerous phytochemical, pharmaceutical, and clinical studies have been conducted on N. sativa, revealing its potential anti-diabetic, anti-cancer, immunomodulator, analgesic, antimicrobial, anti-inflammatory, bronchodilator, renal protective, gastro-protective, antioxidant, and other properties. N. sativa is among the top-ranked evidence-based herbal medications because of its remarkable healing ability. The main bioactive component of the essential oil, thymoquinone, is responsible for the majority of its medicinal capabilities. Nigella sativa is a potent herb which exhibits wide range of pharmaceutical properties, most of which have been confirmed via preclinical and clinical studies. This review may thus be useful for the research community in particular and common people in general to avail the benefits of N. sativa. Keywords: Anti-cancer, Kalonji, Habat-ul-Sauda, Shoneez, Thymoquinone, Nigella sativa, Unani

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Low-dose rosmarinic acid and thymoquinone accelerate wound healing in retinal pigment epithelial cells

Sen

Kaşıkçı

2023

Int Ophthalmol

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Effects of nigella sativa oil on allergic rhinitis: an experimental animal study

Cited by 4 publications

References 25 publications

A randomized, double-blind, placebo-controlled study to evaluate the benefits of a standardized Nigella sativa oil containing 5% thymoquinone in reducing the symptoms of seasonal allergy

A randomized, double-blind, placebo-controlled study to evaluate the benefits of a standardized Nigella sativa oil containing 5% thymoquinone in reducing the symptoms of seasonal allergy

A Comprehensive review of Nigella sativa (kalonji) from the Unani perspective

Low-dose rosmarinic acid and thymoquinone accelerate wound healing in retinal pigment epithelial cells

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