The effect of increase in blood glucose level on hearing loss

Akçay, Güven; Danisman, Betul; Basaranlar, Goksun; Guzel, Pınar; Derın, Narin; Derın, Alper Tunga

doi:10.1016/j.bjorl.2022.06.003

Cited by 5 publications

(4 citation statements)

References 45 publications

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“…While there is a relatively well-understood relationship between hyperglycemia and microvascular damage to peripheral nerves, retina, and the kidneys [ 12 ], there is much less information that specifically looks into other complications of the long-standing hyperglycemia in DM such as hearing function. Akcay et al aimed to evaluate whether changes in blood glucose levels would impact hearing function measured via brainstem auditory evoked potentials (BAEP) and DPOAEs in a streptozotocin induced rat model of DM [ 49 ]. Three months later, blood samples were collected from the animals to measure their blood glucose levels.…”

Section: Resultsmentioning

confidence: 99%

“…Akcay et al conducted a study using rat models to assess the effects of blood glucose levels on hearing, utilizing Brainstem Auditory Evoked Potentials (BAEP) and Distortion Product Otoacoustic Emissions (DPOAEs) in a streptozotocin-induced diabetic model [ 49 ]. The diabetic group exhibited reduced auditory sensitivity, shown by elevated BAEP thresholds at 8 kHz and 16 kHz, while the high blood glucose (HBG) group only showed delays at 8 kHz.…”

Section: Discussionmentioning

confidence: 99%

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Diabetes mellitus, hearing loss, and therapeutic interventions: A systematic review of insights from preclinical animal models

Mittal,

Keith,

Lacey

et al. 2024

PLoS ONE

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Objectives The aim of this systematic review article is to evaluate the relationship between diabetes mellitus (DM) and sensorineural hearing loss (SNHL) utilizing preclinical animal models. The review focused on studies assessing SNHL in diabetic animal models, elucidating the mechanisms of DM-associated SNHL, and exploring the response of diabetic animal models to noise overexposure. We also discussed studies investigating the efficacy of potential therapeutic strategies for amelioration of DM-associated SNHL in the animal models. Methods A protocol of this systematic review was designed a priori and was registered in the PROSPERO database (registration number: CRD42023439961). We conducted a comprehensive search on PubMed, Science Direct, Web of Science, Scopus, and EMBASE databases. A minimum of three reviewers independently screened, selected, and extracted data. The risk of bias assessment of eligible studies was conducted using the Systematic Review Center for Laboratory Animal Experimentation (SYRCLE) tool. Results Following the screening of 238 studies, twelve original articles were included in this systematic review. The studies revealed that hyperglycemia significantly affects auditory function, with various pathological mechanisms contributing to DM-induced hearing impairment, including cochlear synaptopathy, microangiopathy, neuropathy, oxidative stress, mitochondrial abnormalities, and apoptosis-mediated cell death. Emerging interventions, such as Asiaticoside, Trigonelline, Chlorogenic acid, and Huotanquyu granules, demonstrated efficacy in providing otoprotection for preserving cochlear hair cells and hearing function. Conclusions Our systematic review delves into the intricate relationship between DM and hearing impairment in animal models. Future research should focus on targeted therapies to enhance cochlear mitochondrial function, alleviate oxidative stress, and regulate apoptosis. The association between SNHL and social isolation as well as cognitive decline underscores the necessity for innovative therapeutic modalities addressing yet undiscovered mechanisms. Translating findings from animal models to human studies will validate these findings, offering a synergistic approach to effectively manage DM-associated co-morbidities such as hearing impairment.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Diabetes mellitus, hearing loss, and therapeutic interventions: A systematic review of insights from preclinical animal models

Mittal,

Keith,

Lacey

et al. 2024

PLoS ONE

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“…30 Furthermore, more and more studies have proved that hyperglycemia or hyperlipidemia is one of the key factors leading to SNHL. [31][32][33] Previous research has established that insulin receptors, glucose transporters, and insulin signaling components exist in sensory receptors, cochlear supporting cells, stria vascularis, and spiral ligament, which implies that auditory and balance functions can be easily impacted by impaired glucose utilization. [34][35][36][37][38][39] Additionally, hyperglycemia resulting from insulin resistance can instigate a range of functional pathologies, including mitochondrial DNA damage.…”

Section: Discussionmentioning

confidence: 99%

Association Between Triglyceride-Glucose Index and Hearing Threshold Shifts of Adults in the United States: National Health and Nutrition Examination Survey, 2015–2016

Pan,

Chen,

Lin

et al. 2024

JMDH

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Objective Sensorineural Hearing Loss (SNHL) is a representative human sensory impairment, few studies have paid attention to the correlation between the Triglyceride-Glucose (TyG) index and SNHL to date. We conducted this analysis to elucidate the correlation between the TyG index and pure tone hearing thresholds among US adults. Methods Our analysis included 1226 adults (age range: 20 to 69 years old) from the 2015–2016 National Health and Nutrition Examination Survey (NHANES) data. TyG index was scored into three quartiles. Weighted univariate analysis, weighted multivariate linear regression analyses as well as smooth curve fittings evaluated the associations between TyG index and pure tone hearing thresholds. Results In the multiple regression analysis, the second tertile of TyG index was negatively associated with high-frequency hearing thresholds shifts. Furthermore, the non-linear relationships between TyG index and speech-frequency and high-frequency hearing thresholds were identified by smooth curve fittings. After adjusting for potential confounders, the fitted smooth curves were approximately U-shaped, and the two-segment linear regression models were constructed to calculate their inflection points. Conclusion Our findings suggested that the TyG index was nearly U-shaped association with speech-frequency and high-frequency hearing thresholds. These results may imply the importance of maintaining a balanced TyG index in health management.

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“…There is growing attention paid to the relationship between diabetes and inner ear structures. [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ] In particular, there is a wealth of evidence suggesting that hearing loss (HL) may be a disabling complication of diabetes mellitus (DM) [ 26 , 27 ]. The consequences of DM affecting the ear can include the ability to understand speech, the risk of falling, and the onset of tinnitus, with concerns ranging from a lowered quality of life to an increase in mortality.…”

Section: Introductionmentioning

confidence: 99%

Diabetes Mellitus and Hearing Loss: A Complex Relationship

et al. 2023

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Background and Objectives: Discussion is open about the relationship between diabetes (DM) and hearing loss (HL). There is a lot of evidence in the literature suggesting a causal link between these conditions, beyond being considered simple comorbidities. The difficulty in identifying populations free from confounding factors makes it difficult to reach definitive conclusions on the pathophysiological mechanisms at play. Nonetheless, there is numerous evidence that demonstrates how the population affected by DM is more affected by sensorineural HL (SNHL) and exhibit a higher prevalence of idiopathic sudden sensorineural HL (ISSNHL). Materials and Methods: Articles reporting potentially relevant information were reviewed, and the most significant results are discussed in this article. Starting from the possible mechanisms relating to auditory impairment in the diabetic condition, this article summarizes the studies on auditory evaluation in subjects with DM1 and DM2 and addresses the relationship between DM and ISSNHL. Results: DM is considered a risk factor for SNHL, although some studies have reported no relationship when the associations were adjusted for age, gender, and hypertension. Macro and microvascular insults that cause decreased blood flow, oxygen exchange, and ion transport are major complications of hypertension and DM and can have a direct effect on the sensory and support cells of the cochlea. Conclusions: Given the difficulty of carrying out studies on populations without confounding factors, new laboratory studies are strongly required to clarify which specific physiopathological mechanisms underlie the diabetic damage caused to the hearing organs and how pharmacological management may contribute to counteracting the pathophysiological effects of the diabetic condition on the auditory system.

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The effect of increase in blood glucose level on hearing loss

Cited by 5 publications

References 45 publications

Diabetes mellitus, hearing loss, and therapeutic interventions: A systematic review of insights from preclinical animal models

Diabetes mellitus, hearing loss, and therapeutic interventions: A systematic review of insights from preclinical animal models

Association Between Triglyceride-Glucose Index and Hearing Threshold Shifts of Adults in the United States: National Health and Nutrition Examination Survey, 2015–2016

Diabetes Mellitus and Hearing Loss: A Complex Relationship

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