Computed tomography analysis of fascial space involvement demonstrates correlations with laboratory tests, length of hospital stays and admission to the intensive care unit in odontogenic infections

Silva, Renata de Jesus da; Barbosa, Raphaella Ayres Lima; Okamura, Fabio Kenji; Luz, João Gualberto de Cerqueira

doi:10.1016/j.bjorl.2022.04.003

Cited by 2 publications

(2 citation statements)

References 29 publications

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“… 7 Pavan et al [ 18 ] 2020 Brazil Prospective Total: 50 Group1(LOS ≤ 3 days): 17 Group2(LOS > 3 days): 33 Group1: 30.1 ± 15.7 Group2: 32.0 ± 15.6 Group1: 11 (64.7) Group2: 22 (66.7) NLR showed a statistically significant and positive correlation concerning LOS. 6 Silva et al [ 24 ] 2022 Brazil Prospective Total: 66 Total: 32.7 a ratio of 1.4:1, with a predominance of male sex Higher NLR values were significantly associated with greater involvement of fascial regions. 7 Chamora et al [ 25 ] 2021 Indonesia Retrospective Total: 15 Group1(with DM): 6 Group2(without DM): 9 Group1: 50.33 ± 9.54 Group2: 33.56 ± 17.78 Group1: 3 (50) Group2: 6 (66.7) The mean NLR of patients with DM was lower than patients without DM, and there was no significant association between NLR and therapeutic responses.…”

Section: Resultsmentioning

confidence: 99%

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Neutrophil to lymphocyte ratio in odontogenic infection: a systematic review

Ghasemi,

Mortezagholi,

Movahed

et al. 2024

Head Face Med

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Background We conducted this systematic review to compile the evidence for the role of neutrophil to lymphocyte ratio (NLR) in odontogenic infection (OI) and to determine whether NLR is elevated in patients with OI. This was done to aid physicians in better understanding this condition for clinical management. Methods The search was conducted on PubMed, Scopus, and Web of Science libraries on March 30, 2023. Two reviewers independently screened the studies using Endnote software. The Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of the studies. Results A total of nine studies were included in the review. Among patients with OI, positive and statistically significant correlations of NLR were seen with more severe disease, a prolonged hospital stay, postoperative requirement of antibiotics, and total antibiotic dose needed. In the receiver operating characteristics (ROC) analysis, the optimum cut–off level of NLR was 5.19 (specificity: 81, sensitivity: 51). In addition, NLR was correlated with preoperative fever (p = 0.001). Among patients with Ludwig’s Angina, NLR could predict disease severity and length of stay in the hospital (p = 0.032 and p = 0.033, respectively). In addition, the relationship between the NLR and mortality was statistically significant (p = 0.026, specificity of 55.5%, and sensitivity of 70.8%). Among patients with severe oral and maxillofacial space infection, a positive correlation was found between IL-6 and CRP with NLR (rs = 0.773, P = 0.005 and rs = 0.556, P = 0.020, respectively). Also, a higher NLR was considered an essential predictor of organ involvement (P = 0.027) and the number of complications (P = 0.001). However, among diabetes mellitus (DM) patients afflicted with submandibular abscesses, NLR had no association with therapeutic response. Conclusions Many people around the world suffer from OI, and a cheap and fast biomarker is needed for it. Interestingly, inflammation plays a role in this infection, and elevated NLR levels can be a good biomarker of inflammation and, as a result, for OI progression.

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Section: Resultsmentioning

confidence: 99%

“…Silva et al [ 24 ] prospectively collected 66 hospitalized patients with OI, aiming to detect the possible correlations between computed tomographic findings of involved fascial spaces and laboratory markers, length of hospital stays, and Intensive Care Unit (ICU) admission. The mean LOS was 4.3 days.…”

Section: Resultsmentioning

confidence: 99%