Respiratory sleep disorders, nasal obstruction and enuresis in children with non-syndromic Pierre Robin sequence

Banhara, Fábio Luiz; Trindade, Inge Elly Kiemle; Trindade‐Suedam, Ivy Kiemle; Fernandes, Marilyse de Bragança Lopes; Trindade, Sergio Henrique Kiemle

doi:10.1016/j.bjorl.2021.05.002

Cited by 1 publication

(10 citation statements)

References 45 publications

(85 reference statements)

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“…8 As reported, only mild alterations were observed in the group with IRS than in controls (apnea + hypopnea/ hours of sleep = 1.8 ± 1.0 vs 0.54 ± 0.77; minimum oxygen saturation = 94.1 ± 1.5 vs 96.0 ± 0.8). 8 Both studies 8,13 indicate a clinically significant reduction of the sleep-disordered breathing frequency and symptoms than reported among infants. 14…”

Section: Discussionmentioning

confidence: 92%

“…To cite an instance, a high risk for OSA was detected through the Sleep Disturbance Scale for Children in 38.78% of patients with IRS aged 6 to 12 years. 13 Second, the severity of this disorder becomes milder. As seen in the study of Spier et al, 8 7 of 8 individuals with IRS aged 16.3 (±4.6) years, evaluated through 13-channel PSG, presented a higher occurrence of sleep disturbances and apneas than controls ( P ≤ .05), though they did not suffer from frank OSA.…”

Section: Discussionmentioning

confidence: 99%

“…In the literature, it is a well-documented relationship between nasal obstruction and OSA, either in individuals without 10,11 or with craniofacial anomalies, 12 including children with IRS. 13 Reportedly, nasal obstruction increases airway resistance, interfering with airflow dynamics and predisposing to pharyngeal collapse, aggravating OSA symptoms. 10,11…”

Section: Discussionmentioning

confidence: 99%

“…Calculation of the sample size was performed considering the frequency of OSA recently detected in a pediatric population with IRS studied in the same settings where the present study was conducted. 13 From a total population of young adults with an IRS of 137 individuals, a sample size of 30 participants was estimated to predict an expected frequency of 38.78% of OSA, with a margin of error of 15% and test power of 90%.…”

Section: Methodsmentioning

confidence: 99%

“…8,9 Still, previous studies reported that OSA would be associated with respiratory symptoms, especially chronic nasal obstruction, 10–12 which is a chronical condition frequently detected in patients with IRS. 13…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Screening for Obstructive Sleep Apnea and Associated Risk Factors in Adolescents and Adults With Isolated Robin Sequence

Semensato

Trindade

Marzano‐Rodrigues

et al. 2022

The Cleft Palate Craniofacial Journal

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Objective To investigate the subjective risk for obstructive sleep apnea (OSA) in adolescents and young adults with isolated Robin sequence (IRS). Additionally, to investigate the association of OSA risk with respiratory signs/symptoms, and retrognathia. Design Prospective, observational, and cross-sectional study. Setting Tertiary reference hospital for the rehabilitation of craniofacial anomalies. Participants Adolescents and adults (n = 30) with IRS were clinically evaluated and screened through the Berlin Questionnaire (BQ) and Respiratory Symptoms Questionnaire. The maxillomandibular relationship was assessed on lateral cephalograms of those that reached skeletal maturity (n = 13). Polysomnography (PSG) was performed in a subgroup of 4 individuals. Results The mean age of the sample was 18.2 (±3.4) years, 17 (56.7%) were adolescents (14-19 years), and 16 were (53.3%) female, all presented a repaired cleft palate. Clinical Parameters Systemic arterial pressure (118.0 ± 4.1/76.3 ± 4.9 mmHg), body mass index (BMI) (20.9 ± 2.8 kg/m2), neck (33.2 ± 2.3 cm), and waist circumferences (72.0 ± 5.8 cm) were within normal ranges. A skeletal class I pattern was observed in 61.5% of the participants while a class II was seen in 15.4% of them. A high risk for OSA was detected in 16.7%, and it was associated with nasal obstruction, snoring and drowsiness, and a skeletal class II pattern ( P ≤ .05). One patient presented with mild OSA (apnea–hypopnea index [AHI] = 10.1 events/hour) at the PSG exam. Conclusions A high risk for OSA can be observed with a moderate frequency among adolescents and young adults with IRS, especially among those who are concurrently suffering from nasal obstruction, snoring and retrognathia.

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