Oral changes in cocaine abusers: an integrative review

Melo, César Antonio Araújo; Guimarães, Hanna Rabech Garcia; Medeiros, Raphael Christian Fernandes; Souza, Geórgia Costa de Araújo; Santos, Patrícia Bittencourt Dutra dos; Tôrres, Ana Clara Soares Paiva

doi:10.1016/j.bjorl.2021.04.011

Cited by 6 publications

(5 citation statements)

References 38 publications

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“…He reported that of the 22 studies assessed among cocaine users, the prevalence of TMDs was as a consequence of muscular disorder. 42 The research of Chaparro-González et al also supports this finding, reporting that cocaine, methamphetamine and opioids users suffered from bruxism, which increase the probability of TMD. 59.4% of their analysed sample had bruxism while 37.5% had onychophagia.…”

Section: Discussionmentioning

confidence: 79%

“…This finding is similar to an integrative review done by Melo who reported TMDs as the common oral changes along with perforation of the palate, increased risk to periodontal diseases, bruxism, dental caries, destructive lesions of the facial midline, xerostomia and loss of taste function. He reported that of the 22 studies assessed among cocaine users, the prevalence of TMDs was as a consequence of muscular disorder 42 . The research of Chaparro‐González et al also supports this finding, reporting that cocaine, methamphetamine and opioids users suffered from bruxism, which increase the probability of TMD.…”

Section: Discussionmentioning

confidence: 86%

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Prevalence of temporomandibular disorders among psychoactive substances abusers: A systematic review and meta‐analysis

Aldosari

Hassan

Alshahrani

et al. 2023

J of Oral Rehabilitation

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Introduction:The COVID-19 pandemic has had a significant impact on substance abuse patterns in recent times. Many people have experienced increased stress, anxiety, and social isolation, which has led to higher rates of substance abuse and addiction. It impacts on the orofacial region, particularly temporomandibular joint (TMJ).This review was undertaken to assess the association between substance abuse and temporomandibular disorders. (TMDs). Materials and Methods:The databases of PubMed, Google Scholar, Web of Science and Cochrane were searched for articles based of set PECO criteria. A comprehensive search using keywords of "Psychoactive substances", "Illegal substances", "substance abuse", "narcotics", "temporomandibular joint" and "temporomandibular joint disorders" yielded a total of 1405 articles. Modified Newcastle-Ottawa Scale for observational studies assessed the risk of bias of included studies.Results: Two studies were reviewed. Samples recruited were either from rehabilitation centres or prisoners and fell in the second to fourth decade. A definite association was noted between psychoactive substance and TMDs. Moderate to low risk of bias was noted in all the studies evaluated. Conclusion:Further research is needed to better understand the nature of this relationship and the underlying mechanisms involved. It is important for healthcare providers to be aware of this potential association and to screen for substance abuse in patients with TMD symptoms.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 86%

Prevalence of temporomandibular disorders among psychoactive substances abusers: A systematic review and meta‐analysis

Aldosari

Hassan

Alshahrani

et al. 2023

J of Oral Rehabilitation

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“…Cocaine inhalation is associated with injuries and histopathological abnormalities in the upper airway and head and neck sites. [19][20][21][22][23][24] The carcinogenicity of cocaine was predicted previously in the early 1990s using an artificial intelligence system developed for the identification of structural determinants of biological activities. 25 Over the past three decades, empirical studies have been conducted to assess the potential carcinogenic effect of cocaine.…”

Section: Discussionmentioning

confidence: 99%

Cocaine use and head and neck cancer risk: A pooled analysis in the International Head and Neck Cancer Epidemiology Consortium

Zhang,

Chen,

et al. 2024

Cancer Medicine

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BackgroundCocaine is an illegal recreational drug used worldwide, yet little is known about whether cocaine inhalation (smoking/snorting) increases the risk of head and neck cancer (HNC).MethodsThe analyses were conducted by pooling data from three case–control studies with 1639 cases and 2506 controls from the International Head and Neck Cancer Epidemiology Consortium. Epidemiologic data, including cocaine use histories, were obtained in face‐to‐face interviews. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using hierarchical logistic regression models.ResultsControlling for cumulative tobacco and alcohol use, we observed a weak positive association between cocaine use and HNC (ORever vs. never = 1.35, 95% CI: 0.96, 1.90). In stratified analysis, while we did not detect associations among never tobacco or alcohol users due to the limited sample size, the association with cocaine use was observed among tobacco users and alcohol drinkers. ORs for ever and high cumulative use (>18 times) versus never use were 1.40 (95% CI: 0.98, 2.00) and 1.66 (95% CI: 1.03, 2.69) among tobacco users, and 1.34 (95% CI: 0.93, 1.92) and 1.59 (95% CI: 1.00, 2.51) among alcohol drinkers, respectively.ConclusionIn this pooled analysis, we observed a weak positive association between cocaine inhalation and HNC risk. Our findings provide preliminary evidence of the potential carcinogenic effect of cocaine on HNC. Because of study limitations, including limited number of cocaine users, confounding, and heterogeneity across studies, future investigations will require larger studies with more detailed information on cocaine use history.

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“…These CIMDL display a clinical pattern, mimicking aggressive neoplastic and necrotizing inflammatory diseases with positive ANCA tests, radiographic abnormalities, chiefly in the nasal septum and turbinates, or marked histopathological changes, such as Wegener's granulomatosis (WG), atrophic rhinitis, tertiary syphilis, systemic lupus erythematous, lymphoma, tuberculosis, leishmaniasis and fungal infections (aspergillosis, mucormycosis, blastomycosis) [7,[10][11][12]. ANCA are detectable in most patients with WG as well as in most patients with CIMDL.…”

Section: Introductionmentioning

confidence: 99%

“…CIMDL are often overlooked in clinical practise, particularly if a history of cocaine inhalation is not sought or volunteered. Although several reconstructive procedures or maxillary obturator prosthesis have been proposed to repair palatal defects, the best therapeutic choice is still a matter of discussion [10,[14][15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Cocaine-Induced Midline Destructive Lesions (CIMDL): A Real Challenge in Diagnosis

Cosola

Ambrosino

Limongelli

et al. 2021

IJERPH

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The prolonged use of intranasal cocaine can destroy the nasal architecture with the erosion of the palate, turbinates, and ethmoid sinuses causing cocaine-induced midline lesions (CIMDL). The CIMDL display a clinical pattern mimicking variable diseases. The aim of this study was to highlight the difficulties in reaching a correct diagnosis through the evaluation of eight new cases. The diagnostic procedures followed in these patients included: detailed medical history, clinical and histological examination, computed tomography and magnetic resonance imaging, laboratory findings (complete blood count, sedimentation rate, antinuclear antibody test, rheumatoid factor, venereal disease research laboratory test, leishmaniasis and fungal serology, antineutrophil cytoplasmic antibodies ANCA test), and chest X-ray. All patients complained of epistaxis, halitosis, nasal scabs and obstruction, decreased sense of smell and/or taste, oro-nasal regurgitation of solids and liquids with recurrent sinus infections, and chronic facial pain. On clinical examination, all patients showed palate perforation with variable nasal structure involvement and presented a strong positivity for ANCA tests with a p-ANCA pattern. The followed protocol for the CIMDL diagnosis allowed for a relatively quick and conclusive diagnosis in all patients. A multidisciplinary approach is mandatory in the management of CIMDL, involving dental professionals, maxillofacial surgeons, and psychologists.

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Oral changes in cocaine abusers: an integrative review

Cited by 6 publications

References 38 publications

Prevalence of temporomandibular disorders among psychoactive substances abusers: A systematic review and meta‐analysis

Prevalence of temporomandibular disorders among psychoactive substances abusers: A systematic review and meta‐analysis

Cocaine use and head and neck cancer risk: A pooled analysis in the International Head and Neck Cancer Epidemiology Consortium

Cocaine-Induced Midline Destructive Lesions (CIMDL): A Real Challenge in Diagnosis

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